Explanipedia

MiR-216a-3p inhibits the cytotoxicity of primary natural killer cells Open

Rowan Abdelbary, Manon Ragheb, Shereen Ahmed El Sobky, Nagwa S. El‐Badri, Nourhan K. Aboud , et al. · 2025

Introduction The role of miRNAs in regulating variable molecular functions has been sought by scientists for its promising utility in regulating the immune response and, hence, in treating various diseases. In hepatocellular carcinoma (HCC…

Interaction Between Malat1 and miR-499-5p Regulates Meis1 Expression and Function with a Net Impact on Cell Proliferation Open

Salma A Fahim, Manon Ragheb, Ibrahim Hassan Fayed, Aya Osama, Ahmed Karam , et al. · 2025

Meis1 is a transcription factor involved in numerous functions including development and proliferation and has been previously shown to harness cell cycle progression. In this study, we used in silico analysis to predict that miR-499-5p ta…

Drug repurposing of argatroban, glimepiride and ranolazine shows anti-SARS-CoV-2 activity via diverse mechanisms Open

Shereen Ahmed El Sobky, Injie Omar Fawzy, Mahmoud S. Ahmed, Manon Ragheb, Merna Hatem Mohamed Hamad , et al. · 2025

Despite the vast vaccination campaigns against SARS-CoV-2, vaccine-resistant variants have emerged, and COVID-19 is continuing to spread with the fear of emergence of new variants that are resistant to the currently available anti-viral dr…

OncomiR-181a promotes carcinogenesis by repressing the extracellular matrix proteoglycan decorin in hepatocellular carcinoma Open

R.A. Assal, Rowan Bahaa El-din Abd El-bary, R.A. Youness, Mohamed Mamdouh Abdelrahman, Hala Zahran , et al. · 2024

To our knowledge, this is the first study to unveil the direct targeting of DCN by oncomiR-181a. We also highlighted that miR-181a affects targets related to cellular proliferation in HCC which may be partly mediated through inhibition of …

Regulation of IGF2BP1 by miR-186 and its impact on downstream lncRNAs H19, FOXD2-AS1, and SNHG3 in HCC Open

D.A. Habashy, Merna Hatem Mohamed Hamad, Manon Ragheb, Ziad Amr Khalil, Shereen Ahmed El Sobky , et al. · 2022

miR-186 may exert tumor suppressor effects in HCC by repressing oncogenic lncRNAs H19, SNHG3, and FOXD2-AS1 through its effect on IGF2BP1.

Regulation of lipid droplet (LD) formation in hepatocytes via regulation of SREBP1c by non-coding RNAs Open

Shereen Ahmed El Sobky, Nourhan K. Aboud, Nihal Moustafa El assaly, Injie Omar Fawzy, Nada El‐Ekiaby , et al. · 2022

Introduction Increased de novo lipogenesis (DNL) is one of the key factors contributing to fat accumulation and non-alcoholic fatty liver disease (NAFLD). Among the critical transcription factors (TFs) regulating DNL is mTOR and its downst…

Regulation of IGF2BP1 by miR-186 and its Impact on Downstream lncRNAs H19, FOXD2-AS1, and SNHG3 in HCC Open

D.A. Habashy, Merna Hatem Mohamed Hamad, Manon Ragheb, Ziad Amr Khalil, Shereen Ahmed El Sobky , et al. · 2022

Methylation in MIRLET7A3 Gene Induces the Expression of IGF-II and Its mRNA Binding Proteins IGF2BP-2 and 3 in Hepatocellular Carcinoma Open

Amr A. Waly, Nada El‐Ekiaby, R.A. Assal, Mohamed Madbouli Abdelrahman, Karim Adel Hosny , et al. · 2019

miR-let-7a is a tumor suppressor miRNA with reduced expression in most cancers. Methylation of MIRLET7A3 gene was reported to be the cause of this suppression in several cancers; however, it was not explicitly investigated in hepato…

Does the long noncoding RNA HULC act as a sponge or as a downstream target for miR-186 in hepatocellular carcinoma? Open

D.A. Habashy, Karim Adel Hosny, Gamal Esmat, Ahmed Ihab Abdelaziz · 2018

Background: The long noncoding RNA (lncRNA) highly up-regulated in liver cancer (HULC) was identified as an oncogenic noncoding RNA that contributed to hepatocellular carcinoma (HCC) progression. Generally, lncRNAs have been shown to act a…

Correction to: Ectopic delivery of miR-200c diminishes hepatitis C virus infectivity through transcriptional and translational repression of Occludin Open

Dalia S. Elhelw, Sarah E. Riad, Heba Shawer, Nada El‐Ekiaby, Ayman Salah , et al. · 2018

Disruption of Claudin-1 Expression by miRNA-182 Alters the Susceptibility to Viral Infectivity in HCV Cell Models Open

Sarah E. Riad, Dalia S. Elhelw, Heba Shawer, Nada El‐Ekiaby, Ayman Salah , et al. · 2018

HCV entry involves a complex interplay between viral and host molecules. During post-binding interactions, the viral E2 complexes with CD81 receptor for delivery to the tight junction proteins CLDN1 and OCLN, which aid in viral internaliza…

Perturbation of IGF2BP1 Transcriptome upon the Interplay between miR-486-5p and let-7a Open

Ahmed Ihab Abdelaziz, Mourad Ha, Assal Ra, Youness Ra, El Tayebi Hm · 2017

Background: Activation of IGF-1/IGF-1R signaling cascade is a hallmark in Hepatocellular carcinoma (HCC).In our previous work, we showed that miR-486-5p acts as a tumor suppressor miRNA in HCC mainly by vertically blocking IGF-1/IGF-1R axi…

Supplemetary Data.docx Open

Mai Atef Rahmoon, R.A. Youness, Asmaa Gomaa, Mohamed Tarif, Imam Waked , et al. · 2017

Figure S1: NK cell killing effect against Huh-7 target cells at different effector to target (E: T) ratiosThe effect of different effector to target ratios on NK cell killing ability against its target Huh-7 cells was performed as s…

miR-34a: Multiple Opposing Targets and One Destiny in Hepatocellular Carcinoma Open

R.A. Yacoub, Injie Omar Fawzy, R.A. Assal, Karim Adel Hosny, Abdel‐Rahman N. Zekri , et al. · 2016

Background and Aims: The role of miR-34a in hepatocellular carcinoma (HCC) is controversial and several unresolved issues remain, including its expression pattern and relevance to tumor etiology, tumor stage and prognosis, an…

miR-29a Promotes Lipid Droplet and Triglyceride Formation in HCV Infection by Inducing Expression of SREBP-1c and CAV1 Open

Mennatallah Mamdouh Mahdy, Nada El‐Ekiaby, Rana Mahmoud Hashish, Radwa Ayman Salah, Rasha S. Hanafi , et al. · 2016

Aims: To examine the regulation of SREBP-1c and CAV1 by microRNA-29a (miR-29a) in cells infected with hepatitis C virus (HCV) in an attempt to control HCV-induced non-alcoholic fatty liver disease. Methods: In o…

MicroRNA-486-5p enhances hepatocellular carcinoma tumor suppression through repression of IGF-1R and its downstream mTOR, STAT3 and c-Myc Open

R.A. Youness, Hend Mohamed El-Tayebi, R.A. Assal, Karim Hosny, Gamal Esmat , et al. · 2016

The insulin-like growth factor (IGF)-axis has been paradigmatically involved in hepatocellular carcinoma (HCC) tumor initiation, progression and drug resistance. Consequently, members of the IGF-axis and most importantly, IGF-1 receptor (I…

Interplay between microRNA-17-5p, insulin-like growth factor-II through binding protein-3 in hepatocellular carcinoma Open

D.A. Habashy, Hend Mohamed El Tayebi, Injie Omar Fawzy, Karim Adel Hosny, Gamal Esmat , et al. · 2016

These data suggest that regulating IGF-II bioavailability and hence HCC progression can be achieved through targeting IGFBP-3 via manipulating the expression of miRNAs.

Epigenetic regulation of insulin-like growth factor axis in hepatocellular carcinoma Open

Hend Mohamed El Tayebi, Ahmed Ihab Abdelaziz · 2016

The insulin-like growth factor (IGF) signaling pathway is an important pathway in the process of hepatocarcinogenesis, and the IGF network is clearly dysregulated in many cancers and developmental abnormalities. In hepatocellular carcinoma…

Transcriptional activation of the IGF-II/IGF-1R axis and inhibition of IGFBP-3 by miR-155 in hepatocellular carcinoma Open

H.M. El Tayebi, Amr A. Waly, R.A. Assal, Karim Adel Hosny, Gamal Esmat , et al. · 2015

Hepatocellular carcinoma (HCC) is characterized by the aberrant expression of a number of genes that govern crucial signaling pathways. The insulin-like growth factor (IGF) axis is important in this context, and the precise regulation of e…

miR‐1275: A single microRNA that targets the three IGF2‐mRNA‐binding proteins hindering tumor growth in hepatocellular carcinoma Open

Injie Omar Fawzy, Mohammed Tarif Hamza, Karim Adel Hosny, Gamal Esmat, Hend Mohamed El Tayebi , et al. · 2015

This study aimed to identify a single miRNA or miR (microRNA) which regulates the three insulin‐like growth factor‐2‐mRNA‐binding proteins (IGF2BP1, 2 and 3). Bioinformatics predicted miR‐1275 to simultaneously target the three IGF2BPs, an…

Ahmed Ihab Abdelaziz YOU? Author Swipe