Ikuko Hirai
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View article: Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Extramammary Paget Disease 2025
Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Extramammary Paget Disease 2025 Open
Extramammary Paget disease (EMPD) is a rare malignancy that primarily arises in apocrine gland‐bearing areas such as the genital, perianal, and axillary regions. The clinical and biological heterogeneity of EMPD, together with a lack of ev…
View article: Phase II clinical trial of docetaxel and trastuzumab for HER2-positive advanced extramammary Paget’s disease (EMPD-HER2DOC)
Phase II clinical trial of docetaxel and trastuzumab for HER2-positive advanced extramammary Paget’s disease (EMPD-HER2DOC) Open
Background No consensus has been reached regarding the optimal chemotherapy for metastatic extramammary Paget’s disease (EMPD), a rare cutaneous adenocarcinoma, because of the lack of solid evidence from prospective trials. However, the im…
View article: A case of advanced extramammary Paget’s disease with over 5 years of response to modified weekly PET therapy
A case of advanced extramammary Paget’s disease with over 5 years of response to modified weekly PET therapy Open
View article: Clinicopathological significance of androgen receptor expression in extramammary Paget disease: An analysis of 92 patients
Clinicopathological significance of androgen receptor expression in extramammary Paget disease: An analysis of 92 patients Open
Extramammary Paget disease (EMPD) is a rare cutaneous malignant neoplasm arising in apocrine gland-rich areas. Although - like normal apocrine glands - EMPD frequently expresses androgen receptor (AR), the clinical significance of AR expre…
View article: Pre-existing Interstitial Lung Abnormalities and Immune Checkpoint Inhibitor-Related Pneumonitis in Solid Tumors: A Retrospective Analysis
Pre-existing Interstitial Lung Abnormalities and Immune Checkpoint Inhibitor-Related Pneumonitis in Solid Tumors: A Retrospective Analysis Open
Background Immune checkpoint inhibitors (ICIs) have demonstrated efficacy over previous cytotoxic chemotherapies in clinical trials among various tumors. Despite their favorable outcomes, they are associated with a unique set of toxicities…
View article: Cutaneous Inflammatory Pseudotumour of the Face; Does this Almost Forgotten Disease Concept Still Exist?
Cutaneous Inflammatory Pseudotumour of the Face; Does this Almost Forgotten Disease Concept Still Exist? Open
View article: Imatinib mesylate in combination with pembrolizumab in patients with advanced KIT-mutant melanoma following progression on standard therapy
Imatinib mesylate in combination with pembrolizumab in patients with advanced KIT-mutant melanoma following progression on standard therapy Open
Introduction: Genetic alterations of KIT gene are known to be one of the major causes of melanoma. Those are more common in the mucous and acral subtypes and KIT is regarded as major oncogene in Asian melanomas, where the prevalence of the…
View article: Adoptive cell therapy using tumor‐infiltrating lymphocytes for melanoma refractory to immune‐checkpoint inhibitors
Adoptive cell therapy using tumor‐infiltrating lymphocytes for melanoma refractory to immune‐checkpoint inhibitors Open
To evaluate the feasibility of adoptive cell therapy (ACT) using ex vivo‐expanded tumor‐infiltrating lymphocytes (TILs) in Japanese patients with melanoma who failed immune‐checkpoint inhibitor therapy, an open‐label, single‐arm, pilot stu…
View article: Anti-PD-1 antibody therapy for epithelial skin malignancies
Anti-PD-1 antibody therapy for epithelial skin malignancies Open
Introduction: Malignant cutaneous epithelial tumors comprise various skin malignancies originating from the cutaneous epithelium, including cutaneous squamous cell carcinoma, basal cell carcinoma, and malignant cutaneous adnexal tumors. Tr…
View article: Outcomes in patients with extramammary Paget disease with brain metastasis: A retrospective analysis
Outcomes in patients with extramammary Paget disease with brain metastasis: A retrospective analysis Open
View article: Metastatic Cutaneous Squamous Cell Carcinoma in Liver Successfully Treated With Partial Hepatectomy and Adjuvant Irinotecan Chemotherapy
Metastatic Cutaneous Squamous Cell Carcinoma in Liver Successfully Treated With Partial Hepatectomy and Adjuvant Irinotecan Chemotherapy Open
The clinical course of the present case suggests that surgical approaches should also be considered as candidate additional therapy for resectable distant metastatic cSCC.
View article: Updates on the Systemic Treatment of Advanced Non-melanoma Skin Cancer
Updates on the Systemic Treatment of Advanced Non-melanoma Skin Cancer Open
Non-melanoma skin cancers (NMSCs), which represent a diverse group of cutaneous malignancies, are the most common forms of human neoplasia. The incidence of these diseases is increasing due to a number of factors, including that of increas…
View article: Combination Cisplatin-Epirubicin-Paclitaxel Therapy for Metastatic Extramammary Paget's Disease
Combination Cisplatin-Epirubicin-Paclitaxel Therapy for Metastatic Extramammary Paget's Disease Open
Extramammary Paget's disease (EMPD) is a rare cutaneous adenocarcinoma that clinicopathologically resembles breast cancer. The prognosis of metastatic EMPD is poor. Although several chemotherapies have been tried, the effects are temporary…
View article: Efficacy and safety of weekly docetaxel regimen for advanced extramammary Paget’s disease: Retrospective single institute analysis
Efficacy and safety of weekly docetaxel regimen for advanced extramammary Paget’s disease: Retrospective single institute analysis Open