Ikuko Kozone
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View article: Isolation and Structure Elucidation of JBIR-157, a Skeletally Novel Aromatic Polyketide Produced by the Heterologous Expression of a Cryptic Gene Cluster
Isolation and Structure Elucidation of JBIR-157, a Skeletally Novel Aromatic Polyketide Produced by the Heterologous Expression of a Cryptic Gene Cluster Open
Heterologous expression of natural compound biosynthetic gene clusters (BGCs) is a robust approach for not only revealing the biosynthetic mechanisms leading to the compounds, but also for discovering new products from uncharacterized BGCs…
View article: CCDC 2203545: Experimental Crystal Structure Determination
CCDC 2203545: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: C-Methylation of S-adenosyl-L-Methionine Occurs Prior to Cyclopropanation in the Biosynthesis of 1-Amino-2-Methylcyclopropanecarboxylic Acid (Norcoronamic Acid) in a Bacterium
C-Methylation of S-adenosyl-L-Methionine Occurs Prior to Cyclopropanation in the Biosynthesis of 1-Amino-2-Methylcyclopropanecarboxylic Acid (Norcoronamic Acid) in a Bacterium Open
Many pharmacologically important peptides are bacterial or fungal in origin and contain nonproteinogenic amino acid (NPA) building blocks. Recently, it was reported that, in bacteria, a cyclopropane-containing NPA 1-aminocyclopropanecarbox…
View article: Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution Open
Reprogramming of the NRPS/PKS assembly line is an attractive method for the production of new bioactive molecules. However, it is usually hampered by the loss of intimate domain/module interactions required for the precise control of chain…
View article: Frontispiece: Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides
Frontispiece: Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides Open
Polyketide Biosynthesis: Aminopolyols are biosynthesized by polyketide synthases (PKSs). In their Communication on page 1740 I. Abe et al. show that heterologous expression of over 150 kbp PKS gene clusters afforded novel aminopolyols. Phy…
View article: Frontispiz: Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides
Frontispiz: Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides Open
Polyketid-Biosynthese: Die Biosynthese von Aminopolyolen erfolgt durch PKSs. In der Zuschrift auf S. 1766 zeigen I. Abe et al., dass heterologe Expression über 150 kbp großer PKS-Gencluster neuartige Aminopolyole ergeben kann. Ein phylogen…
View article: New acylated anthocyanins from purple yam and their antioxidant activity
New acylated anthocyanins from purple yam and their antioxidant activity Open
Purple yam (Dioscorea alata L.), which is widely distributed in tropical and subtropical regions, is characterized by its color and viscosity. Previous studies have shown that purple yams contain a variety of acylated anthocyanins that exh…