Ikuko T. Smith
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View article: A new mode of action for unconventional NMDA receptors
A new mode of action for unconventional NMDA receptors Open
Presynaptic NMDA receptors can shape timing-dependent long-term depression in a way that departs from their classic postsynaptic role.
View article: Mesoscale functional architecture in medial posterior parietal cortex
Mesoscale functional architecture in medial posterior parietal cortex Open
Summary The posterior parietal cortex (PPC) in mice has various functions including multisensory integration1–3, vision-guided behaviors4–6, working memory7–13, and posture control14,15. However, an integrated understanding of these functi…
View article: Mesoscale functional architecture in medial posterior parietal cortex
Mesoscale functional architecture in medial posterior parietal cortex Open
Summary The posterior parietal cortex (PPC) in mice has various functions including multisensory integration1–3, vision-guided behaviors4–6, working memory7–13, and posture control14,15. However, an integrated understanding of these functi…
View article: Mesoscale functional architecture in medial posterior parietal cortex
Mesoscale functional architecture in medial posterior parietal cortex Open
The posterior parietal cortex (PPC) in mice has various functions including multisensory integration, vision-guided behaviors, working memory, and posture control. However, an integrated understanding of these functions and their cortical …
View article: The Cousa objective: a long working distance air objective for multiphoton imaging <i>in</i><i> </i><i>vivo</i>
The Cousa objective: a long working distance air objective for multiphoton imaging <i>in</i><i> </i><i>vivo</i> Open
Multiphoton microscopy can resolve fluorescent structures and dynamics deep in scattering tissue and has transformed neural imaging, but applying this technique in vivo can be limited by the mechanical and optical constraints of convention…
View article: The Cousa objective: a long working distance air objective for multiphoton imaging <i>in</i><i> </i><i>vivo</i>
The Cousa objective: a long working distance air objective for multiphoton imaging <i>in</i><i> </i><i>vivo</i> Open
Multiphoton microscopy can resolve fluorescent structures and dynamics deep in scattering tissue and has transformed neural imaging, but applying this technique in vivo can be limited by the mechanical and optical constraints of convention…
View article: The Cousa objective: a long working distance air objective for multiphoton imaging<i>in vivo</i>
The Cousa objective: a long working distance air objective for multiphoton imaging<i>in vivo</i> Open
Multiphoton microscopy can resolve fluorescent structures and dynamics deep in scattering tissue, but applying this technique in vivo can be limited by short working distance water-immersion objectives. Here we present an ultra long workin…
View article: The impact of interneurons on nonlinear synaptic integration in the neocortex
The impact of interneurons on nonlinear synaptic integration in the neocortex Open
Excitatory inputs arriving at the dendrites of a neuron can engage active mechanisms that nonlinearly amplify the depolarizing currents. Interneuron-mediated inhibition can modulate this active process, in a subtype-dependent manner. For e…
View article: The influence of a single neuron on its network
The influence of a single neuron on its network Open
View article: Mice use robust and common strategies to discriminate natural scenes
Mice use robust and common strategies to discriminate natural scenes Open
Mice use vision to navigate and avoid predators in natural environments. However, their visual systems are compact compared to other mammals, and it is unclear how well mice can discriminate ethologically relevant scenes. Here, we examined…
View article: Mice use robust and common strategies to discriminate natural scenes
Mice use robust and common strategies to discriminate natural scenes Open
View article: Mice use robust and common strategies to discriminate natural scenes
Mice use robust and common strategies to discriminate natural scenes Open
Mice use vision to navigate and avoid predators in natural environments. However, the spatial resolution of mouse vision is poor compared to primates, and mice lack a fovea. Thus, it is unclear how well mice can discriminate ethologically …
View article: Stream-dependent development of higher visual cortical areas
Stream-dependent development of higher visual cortical areas Open
View article: Wide field-of-view, multi-region, two-photon imaging of neuronal activity in the mammalian brain
Wide field-of-view, multi-region, two-photon imaging of neuronal activity in the mammalian brain Open
View article: Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors
Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors Open
Apoptosis plays an essential role during brain development, yet the precise mechanism by which this pathway is regulated in the brain remains unknown. In particular, mammalian cells are known to express multiple anti-apoptotic Bcl-2 family…