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View article: Correction: Shin et al. miR-29b Regulates TGF-β1-Induced Epithelial–Mesenchymal Transition by Inhibiting Heat Shock Protein 47 Expression in Airway Epithelial Cells. Int. J. Mol. Sci. 2021, 22, 11535
Correction: Shin et al. miR-29b Regulates TGF-β1-Induced Epithelial–Mesenchymal Transition by Inhibiting Heat Shock Protein 47 Expression in Airway Epithelial Cells. Int. J. Mol. Sci. 2021, 22, 11535 Open
In the original publication [...]
View article: Structural insights into butyryl-CoA dehydrogenase and its modeled complex with electron transferring flavoprotein from Faecalibacterium prausnitzii L2-6
Structural insights into butyryl-CoA dehydrogenase and its modeled complex with electron transferring flavoprotein from Faecalibacterium prausnitzii L2-6 Open
Faecalibacterium prausnitzii is a predominant anaerobic bacterium in the human gut microbiome, contributing to host intestinal health through butyrate production and anti-inflammatory effects. The L2-6 strain serves as a representative mod…
View article: Structural basis for substrate-induced activation of 3-hydroxybutyryl-CoA dehydrogenase from Faecalibacterium prausnitzii L2-6
Structural basis for substrate-induced activation of 3-hydroxybutyryl-CoA dehydrogenase from Faecalibacterium prausnitzii L2-6 Open
Dysbiosis of the gut microbiota has increasingly been associated with atopic dermatitis (AD), a chronic inflammatory dermatological disorder. Butyrate, a short-chain fatty acid recognized for its significant anti-inflammatory capabilities,…
View article: Cadherin‐26 Facilitates Transepithelial Migration of Eosinophils in Eosinophilic Chronic Rhinosinusitis
Cadherin‐26 Facilitates Transepithelial Migration of Eosinophils in Eosinophilic Chronic Rhinosinusitis Open
Background Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is characterized by persistent sinonasal inflammation and marked eosinophilic infiltration. Although the relationship between eosinophils and NP formation has been …
View article: Synergistic Exacerbation of Allergic Inflammation by Combined Exposure to Air-pollutants in a Murine Model of Allergic Rhinitis
Synergistic Exacerbation of Allergic Inflammation by Combined Exposure to Air-pollutants in a Murine Model of Allergic Rhinitis Open
Coexposure to PM2.5, formaldehyde, and zinc aggravated allergic inflammation in an OVA-induced murine model, with PM2.5 + zinc showing the strongest synergistic effects. These findings highlight the importance of pollutant-pollutant intera…
View article: Structural Insights and Calcium-Switching Mechanism of Fasciola hepatica Calcium-Binding Protein FhCaBP4
Structural Insights and Calcium-Switching Mechanism of Fasciola hepatica Calcium-Binding Protein FhCaBP4 Open
Fasciola hepatica remains a global health and economic concern, and treatment still relies heavily on triclabendazole. At the parasite–host interface, F. hepatica calcium-binding proteins (FhCaBPs) have a unique EF-hand/DLC-like domain fus…
View article: Assessing Personal PM<sub>2.5</sub> Exposure: A Method Leveraging Movement Routes and Activity Space Information
Assessing Personal PM<sub>2.5</sub> Exposure: A Method Leveraging Movement Routes and Activity Space Information Open
Previous studies have consistently shown a significant correlation between air pollution, particularly PM 2.5 , and various diseases, as well as increased mortality rates. This study introduces a novel approach for predicting time‐specific…
View article: Matrix metalloproteinase-12 by M2 macrophages induced epithelial to mesenchymal transition in chronic rhinosinusitis with nasal polyps
Matrix metalloproteinase-12 by M2 macrophages induced epithelial to mesenchymal transition in chronic rhinosinusitis with nasal polyps Open
Th2 inflammation and epithelial-mesenchymal transition (EMT) play crucial roles in the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to investigate the hypothesis that MMP-12, produced by M2 macroph…
View article: CHI3L1 on fibrinolytic system imbalance in chronic rhinosinusitis with nasal polyp
CHI3L1 on fibrinolytic system imbalance in chronic rhinosinusitis with nasal polyp Open
Background Chronic rhinosinusitis (CRS) is an inflammatory disease affecting more than 10% of the global adult population. It is classified into Th1, Th2, and Th17 endotypes and eosinophilic and non-eosinophilic types. Th2-based inflammati…
View article: Stimulator of Interferon Gene Agonists Induce an Innate Antiviral Response against Influenza Viruses
Stimulator of Interferon Gene Agonists Induce an Innate Antiviral Response against Influenza Viruses Open
The devastating effects of COVID-19 have highlighted the importance of prophylactic and therapeutic strategies to combat respiratory diseases. Stimulator of interferon gene (STING) is an essential component of the host defense mechanisms a…
View article: Inhibitory effect of doxycycline conjugated with deoxycholic acid and polyethylenimine conjugate on nasal fibroblast differentiation and extracellular production
Inhibitory effect of doxycycline conjugated with deoxycholic acid and polyethylenimine conjugate on nasal fibroblast differentiation and extracellular production Open
Background Chronic rhinosinusitis (CRS) is an inflammatory disease affecting the sinuses or nose. Persistent inflammatory responses can lead to tissue remodeling, which is a pathological characteristics of CRS. Activation of fibroblasts in…
View article: Effect of Air Pollutants on Allergic Inflammation in Structural Cells of the Nasal Mucosa
Effect of Air Pollutants on Allergic Inflammation in Structural Cells of the Nasal Mucosa Open
Objectives. Air pollution is an increasing global concern, and its effect on allergic inflammation has attracted the attention of many researchers. Particulate matter (PM) is a major component of ambient air pollution, and heavy metals are…
View article: Deep learning algorithm for the automated detection and classification of nasal cavity mass in nasal endoscopic images
Deep learning algorithm for the automated detection and classification of nasal cavity mass in nasal endoscopic images Open
Nasal endoscopy is routinely performed to distinguish the pathological types of masses. There is a lack of studies on deep learning algorithms for discriminating a wide range of endoscopic nasal cavity mass lesions. Therefore, we aimed to …
View article: Healthcare Experts’ Advisory Unit and Support (HAUS) Program for Medical Device Development in Korea: Introduction of Clinical Unmet Needs-Based Intended Use Establishment (CLUE) Templates
Healthcare Experts’ Advisory Unit and Support (HAUS) Program for Medical Device Development in Korea: Introduction of Clinical Unmet Needs-Based Intended Use Establishment (CLUE) Templates Open
The HAUS program seemed to be helpful for the development teams by providing opinions of clinical experts. And the resultant product, the CLUE templates have been proposed to facilitate collaboration between the development teams and the a…
View article: Eosinophilic Chronic Rhinosinusitis and Pathogenic Role of Protease
Eosinophilic Chronic Rhinosinusitis and Pathogenic Role of Protease Open
Chronic rhinosinusitis (CRS) is an inflammation of the nasal and paranasal sinus mucosa, and eosinophilic CRS (eCRS) is a subtype characterized by significant eosinophil infiltration and immune response by T-helper-2 cells. The pathogenesi…
View article: A Case of Inferior Turbinate Osteonecrosis Due to Denosumab
A Case of Inferior Turbinate Osteonecrosis Due to Denosumab Open
In rare cases, antiresoprtive medications for osteoporosis cause osteonecrosis. Necrotic bone lesions localized at the jaw after the use of antiresorptive medications is named medicationrelated osteonecrosis of the jaw (MRONJ). Although so…
View article: Glycolytic reprogramming is involved in tissue remodeling on chronic rhinosinusitis
Glycolytic reprogramming is involved in tissue remodeling on chronic rhinosinusitis Open
Background Glycolytic reprogramming is a key feature of chronic inflammatory disease. Extracellular matrix (ECM) produced by myofibroblasts plays an important role in tissue remodeling of nasal mucosa in chronic rhinosinusitis (CRS). This …
View article: Wedge resection combined with 3D-printed polycaprolactone mesh for caudal septal deviation
Wedge resection combined with 3D-printed polycaprolactone mesh for caudal septal deviation Open
Background Biocompatibility and stability of three-dimensional printed polycaprolactone mesh grafts for nasal surgery are proven in both animal and human models. However, their safety and durability as batten grafts for caudal septal devia…
View article: Application of Three Dimensional-Printed Polycaprolactone Nasal Mesh With the Figure of 8 Anchoring Suture Technique for Correction of Caudal Septal Subluxation
Application of Three Dimensional-Printed Polycaprolactone Nasal Mesh With the Figure of 8 Anchoring Suture Technique for Correction of Caudal Septal Subluxation Open
Background and Objectives We evaluated the symptom improvement, surgical outcomes and post-operative complications of the figure of 8 anchoring suture technique using polycaprolactone (PCL) nasal mesh for the treatment of caudal septal sub…
View article: A Case of An Inverted Papilloma Originating From a Lacrimal Sac
A Case of An Inverted Papilloma Originating From a Lacrimal Sac Open
Inverted papillomas are benign but invasive tumors with malignant potential characterized by a high recurrence rate. Although most cases arise from the nasal wall and paranasal sinuses, inverted papillomas originating from the nasolacrimal…
View article: Different Methods and Formulations of Drugs and Vaccines for Nasal Administration
Different Methods and Formulations of Drugs and Vaccines for Nasal Administration Open
Nasal drug delivery is advantageous when compared with other routes of drug delivery as it avoids the hepatic first-pass effect, blood–brain barrier penetration, and compliance issues with parenteral administration. However, nasal administ…
View article: Anti-Viral Activities of Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Against Human Respiratory Viruses
Anti-Viral Activities of Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Against Human Respiratory Viruses Open
The endemic and pandemic caused by respiratory virus infection are a major cause of mortality and morbidity globally. Thus, broadly effective antiviral drugs are needed to treat respiratory viral diseases. Small extracellular vesicles deri…
View article: DNMTs Are Involved in TGF-β1-Induced Epithelial–Mesenchymal Transitions in Airway Epithelial Cells
DNMTs Are Involved in TGF-β1-Induced Epithelial–Mesenchymal Transitions in Airway Epithelial Cells Open
Chronic rhinosinusitis (CRS) pathogenesis is closely related to tissue remodeling, including epithelial–mesenchymal transition (EMT). Epigenetic mechanisms play key roles in EMT. DNA methylation, mediated by DNA methyltransferases (DNMTs),…
View article: Eosinophil-Derived Osteopontin Induces the Expression of Pro-Inflammatory Mediators and Stimulates Extracellular Matrix Production in Nasal Fibroblasts: The Role of Osteopontin in Eosinophilic Chronic Rhinosinusitis
Eosinophil-Derived Osteopontin Induces the Expression of Pro-Inflammatory Mediators and Stimulates Extracellular Matrix Production in Nasal Fibroblasts: The Role of Osteopontin in Eosinophilic Chronic Rhinosinusitis Open
Background Eosinophilic chronic rhinosinusitis (ECRS) is a subtype of chronic rhinosinusitis (CRS) and is a refractory or intractable disease. However, a reliable clinical marker or an effective treatment strategy has not yet been establis…
View article: Changing Trends in the Clinical Characteristics and Treatment Strategies for Odontogenic Sinusitis Over the Past 10 Years
Changing Trends in the Clinical Characteristics and Treatment Strategies for Odontogenic Sinusitis Over the Past 10 Years Open
Objectives The incidence of odontogenic sinusitis has been gradually increasing due to the recent increases in invasive dental procedures. This study aimed to describe the clinical features of present patients with odontogenic sinusitis co…
View article: Good’s Syndrome Presenting With Chronic Rhinosinusitis (1 Case Report)
Good’s Syndrome Presenting With Chronic Rhinosinusitis (1 Case Report) Open
The Good’s syndrome is a rare immunodeficiency disease characterized by thymoma and hypogammaglobulinemia. The most common cause of infection in patients with Good’s syndrome is the recurrent sinopulmonary infection. One may assume that th…
View article: miR-29b Regulates TGF-β1-Induced Epithelial–Mesenchymal Transition by Inhibiting Heat Shock Protein 47 Expression in Airway Epithelial Cells
miR-29b Regulates TGF-β1-Induced Epithelial–Mesenchymal Transition by Inhibiting Heat Shock Protein 47 Expression in Airway Epithelial Cells Open
Tissue remodeling contributes to ongoing inflammation and refractoriness of chronic rhinosinusitis (CRS). During this process, epithelial-mesenchymal transition (EMT) plays an important role in dysregulated remodeling and both microRNA (mi…
View article: Microbiome of Unilateral Chronic Rhinosinusitis: A Controlled Paired Analysis
Microbiome of Unilateral Chronic Rhinosinusitis: A Controlled Paired Analysis Open
The sinonasal microbiota in human upper airway may play an important role in chronic rhinosinusitis (CRS). Thus, this study aimed to investigate the human upper airway microbiome in patients with unilateral CRS, and compare the sinonasal m…