Ilan Goldstein
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View article: Stage 0+ lower gastrointestinal (LGI) acute graft-versus-host disease (aGVHD) is associated with high response to non-systemic treatment, low incidence of moderate to severe chronic graft-versus-host disease (cGVHD) and low non-relapse mortality (NRM)
Stage 0+ lower gastrointestinal (LGI) acute graft-versus-host disease (aGVHD) is associated with high response to non-systemic treatment, low incidence of moderate to severe chronic graft-versus-host disease (cGVHD) and low non-relapse mortality (NRM) Open
Introduction: LGI aGVHD remains a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (alloHCT). Stage 0+ LGI aGVHD, defined as low-volume diarrhea (1–499 mL/day or 1–2 episodes/day), is recognized in…
View article: Global epistasis in budding yeast driven by many natural variants whose effects scale with fitness
Global epistasis in budding yeast driven by many natural variants whose effects scale with fitness Open
Global epistasis is a phenomenon in which the effects of genetic perturbations depend on the fitness of the individuals in which they occur. In populations with natural genetic variation, global epistasis arises from interactions between p…
View article: Global epistasis in budding yeast driven by many natural variants whose effects scale with fitness
Global epistasis in budding yeast driven by many natural variants whose effects scale with fitness Open
Global epistasis is a phenomenon in which the effects of genetic perturbations depend on the fitness of the individuals in which they occur. In populations with natural genetic variation, global epistasis arises from interactions between p…
View article: Post-Transplant Pain and Paralysis: Neurologic Amyotrophy as an Atypical Cause of Shoulder Dysfunction Following Hematopoietic Stem Cell Transplant
Post-Transplant Pain and Paralysis: Neurologic Amyotrophy as an Atypical Cause of Shoulder Dysfunction Following Hematopoietic Stem Cell Transplant Open
Background: Neuralgic amyotrophy (NA), also known as Parsonage–Turner syndrome, brachial neuritis, and idiopathic brachial plexopathy, is a rare and potentially debilitating peripheral nerve disorder characterized by acute-onset shoulder p…
View article: Genome-scale analysis of interactions between genetic perturbations and natural variation
Genome-scale analysis of interactions between genetic perturbations and natural variation Open
Interactions between genetic perturbations and segregating loci can cause perturbations to show different phenotypic effects across genetically distinct individuals. To study these interactions on a genome scale in many individuals, we use…
View article: Complex genetics cause and constrain fungal persistence in different parts of the mammalian body
Complex genetics cause and constrain fungal persistence in different parts of the mammalian body Open
Determining how genetic polymorphisms enable certain fungi to persist in mammalian hosts can improve understanding of opportunistic fungal pathogenesis, a source of substantial human morbidity and mortality. We examined the genetic basis o…
View article: Complex genetics cause and constrain fungal persistence in different parts of the mammalian body
Complex genetics cause and constrain fungal persistence in different parts of the mammalian body Open
Determining how genetic polymorphisms enable certain fungi to persist in mammalian hosts can improve understanding of opportunistic fungal pathogenesis, a source of substantial human morbidity and mortality. We examined the genetic basis o…
View article: Genetic Variation in Phenotypic Plasticity
Genetic Variation in Phenotypic Plasticity Open
Genetically distinct individuals frequently exhibit qualitative and quantitative differences in phenotypic plasticity. These heritable differences in plasticity impact many traits of human concern, while also providing a potential substrat…
View article: The complex role of genetic background in shaping the effects of spontaneous and induced mutations
The complex role of genetic background in shaping the effects of spontaneous and induced mutations Open
Spontaneous and induced mutations frequently show different phenotypic effects across genetically distinct individuals. It is generally appreciated that these background effects mainly result from genetic interactions between the mutations…