Ilan Libedinsky
YOU?
Author Swipe
View article: The emergence of genetic variants linked to brain and cognitive traits in human evolution
The emergence of genetic variants linked to brain and cognitive traits in human evolution Open
Human evolution involved major anatomical transformations, including a rapid increase in brain volume over the last 2 million years. Examination of fossil records provides insight into these physical changes but offers limited information …
View article: Polyconnectomic Scoring of Functional Connectivity Patterns Across Eight Neuropsychiatric and Three Neurodegenerative Disorders
Polyconnectomic Scoring of Functional Connectivity Patterns Across Eight Neuropsychiatric and Three Neurodegenerative Disorders Open
Our findings reveal generalizable whole-brain connectivity alterations in brain disorders. Polyconnectomic scoring effectively aggregates disorder-related signatures across the entire brain into an interpretable, participant-specific metri…
View article: A Systematic Review and Meta-Analysis: Research Using the Autism Polygenic Score
A Systematic Review and Meta-Analysis: Research Using the Autism Polygenic Score Open
Objective Genetic factors play a substantial role in the etiology of autism and its co-occurrence with other conditions and traits. The autism polygenic score, derived from the latest autism case-control meta-genome-wide association studie…
View article: Quantifying brain connectivity signatures by means of polyconnectomic scoring
Quantifying brain connectivity signatures by means of polyconnectomic scoring Open
A broad range of neuropsychiatric disorders are associated with alterations in macroscale brain circuitry and connectivity. Identifying consistent brain patterns underlying these disorders by means of structural and functional MRI has prov…
View article: Mapping the genetic evolutionary timeline of human neural and cognitive traits
Mapping the genetic evolutionary timeline of human neural and cognitive traits Open
Human evolution is characterised by extensive changes of body and brain, with perhaps one of the core developments being the fast increase in cranial capacity and brain volume. Paleontological records are the most direct method to study su…
View article: Convergence of Brain Transcriptomic and Neuroimaging Patterns in Schizophrenia, Bipolar Disorder, Autism Spectrum Disorder, and Major Depressive Disorder
Convergence of Brain Transcriptomic and Neuroimaging Patterns in Schizophrenia, Bipolar Disorder, Autism Spectrum Disorder, and Major Depressive Disorder Open
Our findings suggest that normative expression profiles of disorder risk genes confer a shared and spatially patterned vulnerability of the cortex across multiple psychiatric conditions. Transdiagnostic overlap in transcriptomic risk sugge…
View article: Reproducibility of neuroimaging studies of brain disorders with hundreds -not thousands- of participants
Reproducibility of neuroimaging studies of brain disorders with hundreds -not thousands- of participants Open
An important current question in neuroimaging concerns the sample sizes required for producing reliable and reproducible results. Recent findings suggest that brain-wide association studies (BWAS) linking neuroimaging features with behavio…
View article: Power in network neuroscience
Power in network neuroscience Open
Connectomics has become a prime method for studying brain circuitry. The success of these investigations hinge on the capacity to detect the effects present in the data – that is, statistical power. Here, we discuss four main facets of pow…
View article: Changes in Posttraumatic Cognitions Mediate the Effects of Trauma-Focused Therapy on Paranoia
Changes in Posttraumatic Cognitions Mediate the Effects of Trauma-Focused Therapy on Paranoia Open
Background Evidence suggests that in individuals with psychosis, paranoia is reduced after trauma-focused therapy (TFT) aimed at comorbid posttraumatic stress disorder (PTSD). Objective To identify mediators of the effect of TFT on paranoi…