Ilana Solomon
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View article: Prevalence of <i>BRCA1</i> and <i>BRCA2</i> Variants in an Unselected Population of Women With Breast Cancer
Prevalence of <i>BRCA1</i> and <i>BRCA2</i> Variants in an Unselected Population of Women With Breast Cancer Open
Importance Barriers to germline testing make it difficult to determine the prevalence of pathogenic or likely pathogenic (P/LP) variants in BRCA1 and BRCA2 in underrepresented populations. Objective To determine P/LP variants in BRCA1 and …
View article: Rationale and Study Design for a Randomized Clinical Trial of HOPE-Genomics, a Web-Based Intervention to Improve Cancer Patients’ Understanding of Genomic Testing Results
Rationale and Study Design for a Randomized Clinical Trial of HOPE-Genomics, a Web-Based Intervention to Improve Cancer Patients’ Understanding of Genomic Testing Results Open
View article: P471: Uptake of a chatbot for disclosure of germline genetic test results through a universal genetic testing program*
P471: Uptake of a chatbot for disclosure of germline genetic test results through a universal genetic testing program* Open
In order to deliver hereditary cancer (HC) predisposition testing for precision medicine and prevention at scale, alternative models of care are urgently needed. Chatbot use in clinical genetics practice has been primarily limited to the i…
View article: The Evolution of Genetic Testing from Focused Testing to Panel Testing and from Patient Focused to Population Testing: Are We There Yet?
The Evolution of Genetic Testing from Focused Testing to Panel Testing and from Patient Focused to Population Testing: Are We There Yet? Open
The field of cancer genetics has evolved significantly over the past 30 years. Genetic testing has become less expensive and more comprehensive which has changed practice patterns. It is no longer necessary to restrict testing to those wit…
View article: Clinical and laboratory genetic counselor attitudes on the reporting of variants of uncertain significance for multigene cancer panels
Clinical and laboratory genetic counselor attitudes on the reporting of variants of uncertain significance for multigene cancer panels Open
Research suggests variants of uncertain significance (VUSs) present a variety of challenges for genetic counselors (GCs), nongenetics clinicians, and patients. Multigene cancer panels reveal more VUSs than single gene testing as a result o…
View article: ASO Visual Abstract: Integration of Universal Germline Genetic Testing for All New Breast Cancer Patients
ASO Visual Abstract: Integration of Universal Germline Genetic Testing for All New Breast Cancer Patients Open
View article: Integration of Universal Germline Genetic Testing for All New Breast Cancer Patients
Integration of Universal Germline Genetic Testing for All New Breast Cancer Patients Open
View article: Recall of Genomic Testing Results Among Patients with Cancer
Recall of Genomic Testing Results Among Patients with Cancer Open
Background Genomic testing of somatic and germline DNA has transformed cancer care. However, low genetic knowledge among patients may compromise care and health outcomes. Given the rise in genomic testing, we sought to understand patients’…
View article: Engaging Patients in Precision Oncology: Development and Usability of a Web-Based Patient-Facing Genomic Sequencing Report
Engaging Patients in Precision Oncology: Development and Usability of a Web-Based Patient-Facing Genomic Sequencing Report Open
PURPOSE Evidence-based somatic and germline sequencing has transformed cancer care and improves patient outcomes. However, patients’ low genetic literacy and misunderstanding of their own genomic results poses a threat to the realization o…
View article: Experience Gained from the Development and Execution of a Multidisciplinary Multi-syndrome Hereditary Colon Cancer Family Conference
Experience Gained from the Development and Execution of a Multidisciplinary Multi-syndrome Hereditary Colon Cancer Family Conference Open
View article: Prospective Study of Cancer Genetic Variants: Variation in Rate of Reclassification by Ancestry
Prospective Study of Cancer Genetic Variants: Variation in Rate of Reclassification by Ancestry Open
For nonbenign variants in cancer-related genes, the rates at which reclassifications are issued vary by ancestry in ways that differ between BRCA1/2 and other genes.
View article: Somatic TP53 variants frequently confound germ-line testing results
Somatic TP53 variants frequently confound germ-line testing results Open
View article: Genetic Gastric Cancer Susceptibility in the International Clinical Cancer Genomics Community Research Network
Genetic Gastric Cancer Susceptibility in the International Clinical Cancer Genomics Community Research Network Open
View article: Spectrum of mismatch repair gene mutations and clinical presentation of Hispanic individuals with Lynch syndrome
Spectrum of mismatch repair gene mutations and clinical presentation of Hispanic individuals with Lynch syndrome Open
View article: Lynch Syndrome Limbo: Patient Understanding of Variants of Uncertain Significance
Lynch Syndrome Limbo: Patient Understanding of Variants of Uncertain Significance Open
Providers and patients encounter challenges related to the management of Variants of Unknown Significance (VUS). A VUS introduces new counseling dilemmas for the understanding and psychosocial impact of uncertain genetic test results. This…
View article: Corrigendum: Clinical Application of Multigene Panels: Challenges of Next-Generation Counseling and Cancer Risk Management
Corrigendum: Clinical Application of Multigene Panels: Challenges of Next-Generation Counseling and Cancer Risk Management Open
[This corrects the article on p. 208 in vol. 5, PMID: 26484312.].
View article: Next-Generation Testing for Cancer Risk: Perceptions, Experiences, and Needs Among Early Adopters in Community Healthcare Settings
Next-Generation Testing for Cancer Risk: Perceptions, Experiences, and Needs Among Early Adopters in Community Healthcare Settings Open
Despite concerns about utility and ability to interpret/counsel about NGS results, a rapidly increasing uptake of NGS testing among community clinicians was documented. Challenges identified in case discussions point to the need for ongoin…
View article: Clinical Application of Multigene Panels: Challenges of Next-Generation Counseling and Cancer Risk Management
Clinical Application of Multigene Panels: Challenges of Next-Generation Counseling and Cancer Risk Management Open
These figures and cases stress the importance of adequate pre-test counseling in anticipation of higher percentages of positive, VUS, unexpected, and ambiguous test results. Test result ambiguity can be limited by the use of phenotype-spec…
View article: Mutation Spectrum and Risk of Colorectal Cancer in African American Families with Lynch Syndrome
Mutation Spectrum and Risk of Colorectal Cancer in African American Families with Lynch Syndrome Open