Ildikó Badea
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View article: Hierarchical chitosan-lignocellulosic duplex system: An in vitro evaluation of controlled release, anti-pathogenic and hemostatic effects
Hierarchical chitosan-lignocellulosic duplex system: An in vitro evaluation of controlled release, anti-pathogenic and hemostatic effects Open
Critical design challenges that affect novel drug delivery systems concern chemical processing and tissue compatibility of source materials, which highlight the need for sustainable, biocompatible materials and versatile manufacturing meth…
View article: Bioprinting and in vitro characterization of alginate-gelatin constructs incorporating human umbilical vein endothelial cells for potential cardiac tissue engineering
Bioprinting and in vitro characterization of alginate-gelatin constructs incorporating human umbilical vein endothelial cells for potential cardiac tissue engineering Open
Three-dimensional (3D) bioprinting offers transformative potential for cardiac tissue engineering by enabling the fabrication of cell-laden constructs. Yet, key challenges persist, including maintaining cell viability within bioprinted con…
View article: Development and Evaluation of an Alginate-Decellularized Uterine Extracellular Matrix Hydrogel for 3D Bioprinting of Uterine Constructs
Development and Evaluation of an Alginate-Decellularized Uterine Extracellular Matrix Hydrogel for 3D Bioprinting of Uterine Constructs Open
Background and aim: Decellularized uterine extracellular matrix (dUECM) holds promise for uterine tissue engineering due to its preserved bioactive components and structural integrity. However, bioprinting uterine constructs from dUECM rem…
View article: Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering Open
Postoperative adhesions (POAs) are a common and often serious complication following abdominal and gynecologic surgeries, leading to infertility, chronic pain, and bowel obstruction. To address these outcomes, the development of anti-adhes…
View article: Comparative analysis of porcine-uterine decellularization for bioactive-molecule preservation and DNA removal
Comparative analysis of porcine-uterine decellularization for bioactive-molecule preservation and DNA removal Open
Introduction Decellularized uterine extracellular matrix has emerged as a pivotal focus in the realm of biomaterials, offering a promising source in uterine tissue regeneration, research on disease diagnosis and treatments, and ultimately …
View article: A Novel Size-Based Centrifugal Microfluidic Design to Enrich and Magnetically Isolate Circulating Tumor Cells from Blood Cells through Biocompatible Magnetite–Arginine Nanoparticles
A Novel Size-Based Centrifugal Microfluidic Design to Enrich and Magnetically Isolate Circulating Tumor Cells from Blood Cells through Biocompatible Magnetite–Arginine Nanoparticles Open
This paper presents a novel centrifugal microfluidic approach (so-called lab-on-a-CD) for magnetic circulating tumor cell (CTC) separation from the other healthy cells according to their physical and acquired chemical properties. This stud…
View article: Cardiac Tissue Engineering: A Journey from Scaffold Fabrication to In Vitro Characterization
Cardiac Tissue Engineering: A Journey from Scaffold Fabrication to In Vitro Characterization Open
Cardiac tissue engineering has been rapidly evolving with diverse applications, ranging from the repair of fibrotic tissue caused by “adverse remodeling,” to the replacement of specific segments of heart tissue, and ultimately to the creat…
View article: Cell Migration Assays and Their Application to Wound Healing Assays—A Critical Review
Cell Migration Assays and Their Application to Wound Healing Assays—A Critical Review Open
In recent years, cell migration assays (CMAs) have emerged as a tool to study the migration of cells along with their physiological responses under various stimuli, including both mechanical and bio-chemical properties. CMAs are a generic …
View article: Recent Developments in Inertial and Centrifugal Microfluidic Systems along with the Involved Forces for Cancer Cell Separation: A Review
Recent Developments in Inertial and Centrifugal Microfluidic Systems along with the Involved Forces for Cancer Cell Separation: A Review Open
The treatment of cancers is a significant challenge in the healthcare context today. Spreading circulating tumor cells (CTCs) throughout the body will eventually lead to cancer metastasis and produce new tumors near the healthy tissues. Th…
View article: Optimized Chitosan-Based Nanoemulsion Improves Luteolin Release
Optimized Chitosan-Based Nanoemulsion Improves Luteolin Release Open
Luteolin (LUT) is a flavonoid found in several edible and medicinal plants. It is recognized for its biological activities such as antioxidant, anti-inflammatory, neuroprotective, and antitumor effects. However, the limited water solubilit…
View article: Optimization of 3D printing and in vitro characterization of alginate/gelatin lattice and angular scaffolds for potential cardiac tissue engineering
Optimization of 3D printing and in vitro characterization of alginate/gelatin lattice and angular scaffolds for potential cardiac tissue engineering Open
Background: Engineering cardiac tissue that mimics the hierarchical structure of cardiac tissue remains challenging, raising the need for developing novel methods capable of creating structures with high complexity. Three-dimensional (3D)-…
View article: The Additive Manufacturing Approach to Polydimethylsiloxane (PDMS) Microfluidic Devices: Review and Future Directions
The Additive Manufacturing Approach to Polydimethylsiloxane (PDMS) Microfluidic Devices: Review and Future Directions Open
This paper presents a comprehensive review of the literature for fabricating PDMS microfluidic devices by employing additive manufacturing (AM) processes. AM processes for PDMS microfluidic devices are first classified into (i) the direct …
View article: A Preliminary Experimental Study of Polydimethylsiloxane (PDMS)-To-PDMS Bonding Using Oxygen Plasma Treatment Incorporating Isopropyl Alcohol
A Preliminary Experimental Study of Polydimethylsiloxane (PDMS)-To-PDMS Bonding Using Oxygen Plasma Treatment Incorporating Isopropyl Alcohol Open
Polydimethylsiloxane (PDMS) is a widely used material for soft lithography and microfabrication. PDMS exhibits some promising properties suitable for building microfluidic devices; however, bonding PDMS to PDMS and PDMS to other materials …
View article: Design of Smart Nanodiamonds: Introducing pH Sensitivity to Improve Nucleic Acid Carrier Efficiency of Diamoplexes
Design of Smart Nanodiamonds: Introducing pH Sensitivity to Improve Nucleic Acid Carrier Efficiency of Diamoplexes Open
The mechanism of cellular uptake and intracellular fate of nanodiamond/nucleic acid complexes (diamoplexes) are major determinants of its performance as a gene carrier. Our group designed lysine-nanodiamonds (K-NDs) as vectors for nucleic …
View article: Development and characterization of liposomal formulation containing phytosterols and tocopherols for reducing low-density lipoprotein cholesterol.
Development and characterization of liposomal formulation containing phytosterols and tocopherols for reducing low-density lipoprotein cholesterol. Open
Purpose: Phytosterols are plant sterols with structural resemblance to cholesterol. United States Food and Drug Administration (FDA) and Health Canada have approved phytosterols as a cholesterol-lowering agent due to their ability to signi…
View article: Circulating Tumor Cell Separation of Blood Cells and Sorting in novel Microfluidic approaches: a review
Circulating Tumor Cell Separation of Blood Cells and Sorting in novel Microfluidic approaches: a review Open
Separation and interpretation of rebellious Circulating Tumor Cells (CTCs) originating from the primary tumor or cancer tissue plays a significant role in diagnostics, cancer progression analyses, suitable medicine exploration, and treatme…
View article: Subcoracoid Impingement – A Global View
Subcoracoid Impingement – A Global View Open
Modifications in joint anatomy on both soft and bony tissue level play a key role in subcoracoid impingement syndrome. The diagnostic is primarily clinical and is based on patient history and functional tests. Imaging tests support, but do…
View article: Mass Spectrometric Detection and Characterization of Metabolites of Gemini Surfactants Used as Gene Delivery Vectors
Mass Spectrometric Detection and Characterization of Metabolites of Gemini Surfactants Used as Gene Delivery Vectors Open
Gemini surfactants are a class of lipid molecules that have been successfully used in vitro and in vivo as nonviral gene delivery vectors. However, the biological fate of gemini surfactants has not been well investigated. In particular, th…
View article: Drug Delivery Technology Development in Canada
Drug Delivery Technology Development in Canada Open
Canada continues to have a rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community.
View article: Drug Delivery Technology Development in Canada
Drug Delivery Technology Development in Canada Open
Canada has a long and rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community. Drug delivery refers to approaches, formulations, technologies, and syst…
View article: Inclusion Complexes of Melphalan with Gemini-Conjugated β-Cyclodextrin: Physicochemical Properties and Chemotherapeutic Efficacy in In-Vitro Tumor Models
Inclusion Complexes of Melphalan with Gemini-Conjugated β-Cyclodextrin: Physicochemical Properties and Chemotherapeutic Efficacy in In-Vitro Tumor Models Open
β-cyclodextrin (βCD) has been widely explored as an excipient for pharmaceuticals and nutraceuticals as it forms stable host–guest inclusion complexes and enhances the solubility of poorly soluble active agents. To enhance intracellular dr…
View article: Cellular Uptake and Distribution of Gemini Surfactant Nanoparticles Used as Gene Delivery Agents
Cellular Uptake and Distribution of Gemini Surfactant Nanoparticles Used as Gene Delivery Agents Open
Gemini surfactants are promising molecules utilized as non-viral gene delivery vectors. However, little is known about their cellular uptake and distribution after they release their therapeutic cargo. Therefore, we quantitatively evaluate…
View article: Polymeric Nanoparticles in Gene Therapy: New Avenues of Design and Optimization for Delivery Applications
Polymeric Nanoparticles in Gene Therapy: New Avenues of Design and Optimization for Delivery Applications Open
The field of polymeric nanoparticles is quickly expanding and playing a pivotal role in a wide spectrum of areas ranging from electronics, photonics, conducting materials, and sensors to medicine, pollution control, and environmental techn…