Explanipedia

Fabrication and Computational Study of pH-Responsive Chitosan/Poly(HEMA-co-2-HMBA) Microparticles for Controlled, Site-Specific Doxorubicin Delivery Open

N. Sivagangi Reddy, Ramesh Kumar Chitumalla, Jaeyoung Choi, Joonkyung Jang, Hyung Il Seo , et al. · 2025

As a chitosan (CTS)-based drug carrier (DC) for doxorubicin (DOX) delivery, poly(2-hydroxyethyl methacrylate-co-2-hydroxy-4-N-methacrylamidobenzoic acid) [poly(HEMA-co-2-HMBA)] (PHCH) was successfully grafted onto chitosan to fabricate DOX…

L-Threonine-Derived Biodegradable Polyurethane Nanoparticles for Sustained Carboplatin Release Open

Seoeun Oh, Sooyong Park, Hyung Il Seo, Ildoo Chung · 2024

Background and objectives: The use of polymeric nanoparticles (NPs) in drug delivery systems offers the advantages of enhancing drug efficacy and minimizing side effects; Methods: In this study, L-threonine polyurethane (LTPU) NPs have bee…

Synthesis of reaction promoters for epoxy polymerization: Enhancing storage stability and mechanical properties of one‐pot epoxy systems Open

Da Young Lee, Hye‐Jin Kim, Hyeon‐Gook Kim, Meysam Tayebi, Jong‐Hyun Kim , et al. · 2024

One‐pot epoxy formulations, containing uncured resin, curing agent, and promoter, require the promoter to be insoluble in the resin at room temperature to prevent premature polymerization. Here, we introduce three novel reaction promoters …

Derivatization of Hyaluronan to Target Neuroblastoma and Neuroglioma Expressing CD44 Open

Vo Van Giau, Kummara Madhusudana Rao, Ildoo Chung, Chang‐Sik Ha, Seong Soo A. An , et al. · 2024

Therapeutics for actively targeting over-expressed receptors are of great interest because the majority of diseased tissues originate from normal cells and do not possess a unique receptor from which they can be differentiated. One such re…

Depolymerized Chitosan-g-[Poly(MMA-co-HEMA-cl-EGDMA)] Based Nanogels for Controlled Local Release of Bupivacaine Open

N. Sivagangi Reddy, Soojeong Choi, Sooyong Park, Chang‐Sik Ha, Youngmi Jung , et al. · 2023

This study is designed to formulate and characterize chitosan-based nanogels that provide the controlled delivery of anesthetic drugs, such as bupivacaine (BPV), for effective postoperative pain management over prolonged periods of time. D…

Effects of Recycled Polymer on Melt Viscosity and Crystallization Temperature of Polyester Elastomer Blends Open

Ji-Eun Lee, Jin Woo Lee, Jae-Wang Ko, Kyung-Il Jo, Hyun‐Ju Park , et al. · 2023

As the world is paying attention to the seriousness of environmental pollution, the need for a resource circulation economy is emerging due to the development of eco-friendly industrial groups. In particular, the recycling of thermoplastic…

Fabrication and properties of 3D printable dental composite containing catechol polymer Open

Chaeyoung Jeon, Ildoo Chung · 2023

Catechol-containing polymers, which have excellent adhesion function derived from mussels, have recently attracted much attention.Strong interaction between interfaces due to the catechol group with the hydrogen bond allows to apply to var…

Synthesis and characterization of highly stretchable polyurethane based on polyrotaxane composed of movable non-covalent bonds Open

Ji‐Hyun Lee, Sumin Kwak, Jinwoong Jung, Ildoo Chung · 2023

Synthesis and characterization of polyrotaxane based on mono-6-tosyl-β -cyclodextrin Open

Chaijun Lee, Ji-Hyun Lee, Jinwoong Jung, Ildoo Chung · 2023

β-Cyclodextrin(β-CD) is a type of cyclic oligosaccharide used in various fields such as drug delivery, gene therapy, catalyst, chemical sensor, and liquid crystal.Mono-6-deoxy-6-(p-tolylsulfonyl)-β-cyclodextrin (TsO-β-CD) was synthesized b…

Synthesis and characterization of flexible and strong polyurethane using PPG-βCD-polyrotaxane as a chain extender Open

Ji‐Hyun Lee, Sumin Kwak, Md Hasan Turabee, Kyung‐Man Choi, Ildoo Chung · 2023

Highly stretchable polymer have getting much attention because of their unique properties.In this study, a highly stretchable polymer was synthesized by crosslinking polyurethane with pre-synthesized polyrotaxane from polypropylene glycol …

Fabrication and properties of PEKK-based hybrid 3D printable dental composite resin Open

Chaeyoung Jeon, Su-Jin Kim, Ildoo Chung · 2023

Fabrication and Properties of PEKK-based Hybrid 3D Printable Dental Composite ResinPoly aryl ether ketones (PAEKs) has now gradually become the leading polymer material in the fields of biomedical polymer, due to its good biocompatibility …

Synthesis and characterization of L-lysine polyurethane (LPU) nanoparticles for drug delivery system Open

Soojeong Choi, Seoeun Oh, Ildoo Chung · 2023

To obtain biodegradable biomaterial for matrix of drug delivery, L-lysine polyurethane(LPU) was designed using the biodegradable triblock oligomer polylactide-poly(ethylene glycol)-polylactide(PLA-PEG-PLA) as a soft segment, 1,6-hexamethyl…

Synthesis and characterization of L-threonine polyurethane (LTHU) nanoparticles for drug delivery system Open

Soojeong Choi, Seoeun Oh, Ildoo Chung · 2023

ROS- and pH-Responsive Polydopamine Functionalized Ti3C2Tx MXene-Based Nanoparticles as Drug Delivery Nanocarriers with High Antibacterial Activity Open

Weijin Zhang, Shuwei Li, Veena Vijayan, Jun Seok Lee, Sung Soo Park , et al. · 2022

Premature drug release and poor controllability is a challenge in the practical application of tumor therapy, which may lead to poor chemotherapy efficacy and severe adverse effects. In this study, a reactive oxygen species (ROS)-cleavable…

Dual (pH- and ROS-) Responsive Antibacterial MXene-Based Nanocarrier for Drug Delivery Open

Weijin Zhang, Shuwei Li, Yong‐Zhu Yan, Sung Soo Park, Anandhu Mohan , et al. · 2022

In this study, a novel MXene (Ti3C2Tx)-based nanocarrier was developed for drug delivery. MXene nanosheets were functionalized with 3, 3′-diselanediyldipropionic acid (DSeDPA), followed by grafting doxorubicin (DOX) as a model drug to the …

Interfacial Properties and Melt Processability of Cellulose Acetate Propionate Composites by Melt Blending of Biofillers Open

Ji-Eun Lee, Seung‐Bo Shim, Jae Hyung Park, Ildoo Chung · 2022

A series of eco-friendly biocomposites with improved mechanical properties and interfacial interaction were prepared by melt-mixing natural fibers using a cellulose acetate derivative as a polymer matrix and used to evaluate their mechanic…

Polyol and polyurethane containing bisphenol‐Z: Synthesis and application for toughening epoxy Open

Da Young Lee, Hye Jin Kim, Hyeon‐Gook Kim, Choong‐Sun Lim, Ildoo Chung , et al. · 2022

Despite their excellent properties, epoxy resins have the disadvantage of low toughness. With the aim to improve the toughness of epoxy resin, polyol and polyurethane are synthesized using bisphenol‐Z (BPZ). The synthesized material is dis…

Polydopamine/Polypyrrole Modified Graphite Felt Enhances Biocompatibility for Electroactive Bacteria and Power Density of Microbial Fuel Cell Open

Min‐Soo Kim, Shuwei Li, Da Seul Kong, Young Eun Song, Sooyong Park , et al. · 2022

Fabrication and Biological Activities of Plasmid DNA Gene Carrier Nanoparticles Based on Biodegradable l-Tyrosine Polyurethane Open

Sooyong Park, Yang Yun, Bum-Joon Park, Hyung Il Seo, Ildoo Chung · 2021

Gene therapy is a suitable alternative to chemotherapy due to the complications of drug resistance and toxicity of drugs, and is also known to reduce the occurrence of cellular mutation through the use of gene carriers. In this study, gene…

Biodegradable PCL-b-PLA Microspheres with Nanopores Prepared via RAFT Polymerization and UV Photodegradation of Poly(Methyl Vinyl Ketone) Blocks Open

Taeyoon Kim, Sorim Lee, Sooyong Park, Ildoo Chung · 2021

Biodegradable triblock copolymers based on poly(ε-caprolactone) (PCL) and poly(lactic acid) (PLA) were synthesized via ring-opening polymerization of L-lactide followed by reversible addition–fragmentation chain-transfer (RAFT) polymerizat…

Synthesis and characterization of star‐shaped PMMA using low‐ppm ARGET ATRP approach and changing to rigid powder for bone cement Open

Mai Duc Huynh, Nguyen Thi Dieu Linh, Khuc Duong Huy, Ildoo Chung, Do Quang Tham · 2021

Some low‐ppm concentrations of Cu II complex catalyst (15, 30 and 60 ppm) were used for synthesis of 4‐arm star PMMA (4sPMMA) via Atom Transfer Radical Polymerization using Activators Regenerated by Electron Transfer approach (ARGET ATRP).…

Synthesis of size-controlled and highly monodispersed silica nanoparticles using a short alkyl-chain fluorinated surfactant Open

Saravanan Nagappan, Anandhu Mohan, Anju Maria Thomas, Jongman Yoo, Nadim Eid , et al. · 2021

Shape, size, and morphology controlled synthesis of monodispersed silica nanoparticles using 3-hydroxy-2-(trifluoromethyl)-propanoic acid (MAF-OH) surfactant.

A study on the comparative test of chemical and thermal properties of virgin and recycled PET products Open

Kyoung Pil Kim, Kyung Jin Seo, Sooyong Park, Ildoo Chung · 2021

Synthesis and Characterization of Polyfumarateurethane Nanoparticles for Sustained Release of Bupivacaine Open

Sooyong Park, Jiin Kang, Ji‐Young Yoon, Ildoo Chung · 2020

Biodegradable polyfumarateurethane (PFU) for use as a bupivacaine delivery vehicle, synthesized using di-(2-hydroxypropyl fumarate) (DHPF), polyethylene glycol (PEG) and 1,6-hexamethylene diisocyanate (HMDI), was designed to be degradable …

Syntheses of polyrotaxane conjugated with 5-fluorouracil and vitamins with improved antitumor activities Open

Taeyoon Kim, Soo Yong Park, Myeong‐Hee Lee, Dong‐Hyun Kim, Ildoo Chung · 2018

New antitumor active polyrotaxanes, presynthesized from β-cyclodextrin and polypropylene glycol, were first end capped with antitumor active drug, 5-fluorouracil, and further conjugated with 5-fluorouracil and various bioactive vitamin der…

Synthesis and characterization of (4-arm-star-PMMA)/PMMA-g-SiO2 hybrid nanocomposites Open

Do Quang Tham, Hoang Thai, Nguyen Vu Giang, Nguyen Thi Kim Dung, Ildoo Chung · 2018

This study provides a route to prepare 4-arm star poly(methyl methacrylate) (4sPMMA)/PMMA grafted SiO 2 (PMMA-g-SiO 2 ) hybrid nanocomposites that can be used as 3D printing material and filler for dental materials. First, 4sPMMA was synth…

MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression Open

Jeongeun Hyun, Sihyung Wang, Jieun Kim, Kummara Madhusudana Rao, Soo Yong Park , et al. · 2016

Hedgehog (Hh) signalling regulates hepatic fibrogenesis. MicroRNAs (miRNAs) mediate various cellular processes; however, their role in liver fibrosis is unclear. Here we investigate regulation of miRNAs in chronically damaged fibrotic live…

Preparation of Superhydrophobic Surfaces Using Agglomeration Control of Silica Nanoparticles by Organic Solvent and Non-fluoride Self-assembled Monolayers Open

Taeyoon Kim, Jin Jeong, Ildoo Chung · 2015

본 연구에서는 발수성 재료로 쓰이고 상대적으로 가격이 비싼 불소계 실란을 대체하기 위해 octadecyltrichlorosilane (OTS)을 사용하였다. 코팅층의 기계적 접착강도를 향상시키기 위해 무기바인더를 산 촉매 하에서 졸-겔 반응에 의해 분산시켜 합성하였다. 합성된 실리카 나노입자는 나노크기의 거칠기를 제공하기 때문에 초소수성을 쉽게 얻기 어려우므로 유기용매에 의한 입자의 응집을 유도하였다. 실리카 나노입자의 적절…

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