Ilham Seffouh
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View article: Structure and functional impact of glycosaminoglycan modification of HSulf-2 endosulfatase revealed by atomic force microscopy and mass spectrometry
Structure and functional impact of glycosaminoglycan modification of HSulf-2 endosulfatase revealed by atomic force microscopy and mass spectrometry Open
The human sulfatase HSulf-2 is one of only two known endosulfatases that play a decisive role in modulating the binding properties of heparan sulfate proteoglycans on the cell surface and in the extracellular matrix. Recently, HSulf-2 was …
View article: Sample preparation for TMT-based total and phospho-proteomic analysis of cells and tissues v1
Sample preparation for TMT-based total and phospho-proteomic analysis of cells and tissues v1 Open
Mass spectrometry-based proteomics and phosphoproteomics are highly sensitive and un-biased techniques to study the proteome and phosphoproteome at a global scale. Sample preparation is a key element for the generation of high quality, rep…
View article: Extracellular endosulfatase Sulf-2 harbors a chondroitin/dermatan sulfate chain that modulates its enzyme activity
Extracellular endosulfatase Sulf-2 harbors a chondroitin/dermatan sulfate chain that modulates its enzyme activity Open
Sulfs represent a class of unconventional sulfatases which provide an original post-synthetic regulatory mechanism for heparan sulfate polysaccharides and are involved in multiple physiopathological processes, including cancer. However, Su…
View article: Discrimination of sulfated isomers of chondroitin sulfate disaccharides by HILIC-MS
Discrimination of sulfated isomers of chondroitin sulfate disaccharides by HILIC-MS Open
View article: Extracellular endosulfatase Sulf-2 harbours a chondroitin/dermatan sulfate chain that modulates its enzyme activity
Extracellular endosulfatase Sulf-2 harbours a chondroitin/dermatan sulfate chain that modulates its enzyme activity Open
Sulfs represent a class of unconventional sulfatases, which differ from all other members of the sulfatase family by their structures, catalytic features and biological functions. Through their specific endosulfatase activity in extracellu…
View article: Extracellular Endosulfatase Sulf-2 Harbours a Chondroitin/Dermatan Sulfate Chain That Modulates Its Enzyme Activity
Extracellular Endosulfatase Sulf-2 Harbours a Chondroitin/Dermatan Sulfate Chain That Modulates Its Enzyme Activity Open
View article: Mass spectrometry analysis of the human endosulfatase Hsulf-2
Mass spectrometry analysis of the human endosulfatase Hsulf-2 Open
The human 6-O-endosulfatases HSulf-1 and -2 catalyze the region-selective hydrolysis of the 6-O-sulfate group of the glucosamine residues within sulfated domains of heparan sulfate, thereby ensuring a unique and original post…