Ilias Masouris
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View article: Pharmacologic depletion of border-associated macrophages worsens disease in a mouse model of meningitis
Pharmacologic depletion of border-associated macrophages worsens disease in a mouse model of meningitis Open
View article: Periprocedural unfractionated heparin bolus during endovascular treatment in acute ischemic stroke does more harm than good
Periprocedural unfractionated heparin bolus during endovascular treatment in acute ischemic stroke does more harm than good Open
Background Unfractionated heparin (UFH) bolus is occasionally administered during endovascular treatment (EVT) to reduce thrombotic complications in acute ischemic stroke patients. However, the MR CLEAN-MED trial showed an increase in symp…
View article: Combining antibiotic with anti-TLR2/TLR13 therapy prevents brain pathology in pneumococcal meningitis
Combining antibiotic with anti-TLR2/TLR13 therapy prevents brain pathology in pneumococcal meningitis Open
Despite effective antibiotic therapy, brain-destructive inflammation often cannot be avoided in pneumococcal meningitis. The causative signals are mediated predominantly through TLR-recruited myeloid differentiation primary response adapto…
View article: Telemedical stroke care significantly improves patient outcome in rural areas: Long-term analysis of the German NEVAS network
Telemedical stroke care significantly improves patient outcome in rural areas: Long-term analysis of the German NEVAS network Open
Background: Comprehensive stroke centers (CSC) offer state-of-the-art stroke care in metropolitan centers. However, in rural areas, sufficient stroke expertise is much scarcer. Recently, telemedical stroke networks have offered instant con…
View article: Case report: Anti septin-5-encephalitis as a treatable cause of cerebellar ataxia and psychiatric symptoms
Case report: Anti septin-5-encephalitis as a treatable cause of cerebellar ataxia and psychiatric symptoms Open
Objectives Anti-septin-5 encephalitis is a rare disease with only few published cases, mainly based on retrospective CSF and serum analyses. Predominant symptoms are cerebellar ataxia and oculomotor abnormalities. Due to the rareness of th…
View article: Erratum to ’Evaluation of vessel-wall contrast-enhancement on high-resolution MRI in European patients with Moyamoya disease’ [Journal of Stroke and Cerebrovascular Diseases Volume 32, Issue 6, June 2023, 107135]
Erratum to ’Evaluation of vessel-wall contrast-enhancement on high-resolution MRI in European patients with Moyamoya disease’ [Journal of Stroke and Cerebrovascular Diseases Volume 32, Issue 6, June 2023, 107135] Open
View article: Translocator protein (TSPO)-PET as diagnostic and monitoring tool in COVID-19 related MRI-negative brainstem encephalitis: a case report
Translocator protein (TSPO)-PET as diagnostic and monitoring tool in COVID-19 related MRI-negative brainstem encephalitis: a case report Open
View article: Quantitative proteomic analysis of cerebrospinal fluid from patients with idiopathic facial nerve palsy
Quantitative proteomic analysis of cerebrospinal fluid from patients with idiopathic facial nerve palsy Open
Background and purpose Idiopathic facial palsy (IFP) accounts for over 60% of peripheral facial palsy (FP) cases. The cause of IFP remains to be determined. Possible etiologies are nerve swelling due to inflammation and/or viral infection.…
View article: CXCL13 and CXCL9 CSF Levels in Central Nervous System Lymphoma—Diagnostic, Therapeutic, and Prognostic Relevance
CXCL13 and CXCL9 CSF Levels in Central Nervous System Lymphoma—Diagnostic, Therapeutic, and Prognostic Relevance Open
Background: Diagnostic delay and neurologic deterioration are still a problem for the treatment of rapidly progressing CNS lymphoma (CNSL); there is an unmet need for a diagnostic test with a high diagnostic yield and limited risk, minimiz…
View article: Tumor Lactic Acidosis: Protecting Tumor by Inhibiting Cytotoxic Activity Through Motility Arrest and Bioenergetic Silencing
Tumor Lactic Acidosis: Protecting Tumor by Inhibiting Cytotoxic Activity Through Motility Arrest and Bioenergetic Silencing Open
Adoptive T cell therapy (ACT) is highly effective in the treatment of hematologic malignancies, but shows limited success in solid tumors. Inactivation of T cells in the tumor milieu is a major hurdle to a wider application of ACT. Cytotox…
View article: Combined therapy with ceftriaxone and doxycycline does not improve the outcome of meningococcal meningitis in mice compared to ceftriaxone monotherapy
Combined therapy with ceftriaxone and doxycycline does not improve the outcome of meningococcal meningitis in mice compared to ceftriaxone monotherapy Open
View article: In vivo proteomics identifies the competence regulon and AliB oligopeptide transporter as pathogenic factors in pneumococcal meningitis
In vivo proteomics identifies the competence regulon and AliB oligopeptide transporter as pathogenic factors in pneumococcal meningitis Open
Streptococcus pneumoniae (pneumococci) is a leading cause of severe bacterial meningitis in many countries worldwide. To characterize the repertoire of fitness and virulence factors predominantly expressed during meningitis we performed ni…
View article: Virulence Traits of a Serogroup C Meningococcus and Isogenic <i>cssA</i> Mutant, Defective in Surface-Exposed Sialic Acid, in a Murine Model of Meningitis
Virulence Traits of a Serogroup C Meningococcus and Isogenic <i>cssA</i> Mutant, Defective in Surface-Exposed Sialic Acid, in a Murine Model of Meningitis Open
In serogroup C Neisseria meningitidis , the cssA ( siaA ) gene codes for an UDP- N -acetylglucosamine 2-epimerase that catalyzes the conversion of UDP- N -acetyl-α- d -glucosamine into N -acetyl- d -mannosamine and UDP in the first step in…
View article: A Specific Reduction in Aβ1−42 vs. a Universal Loss of Aβ Peptides in CSF Differentiates Alzheimer's Disease From Meningitis and Multiple Sclerosis
A Specific Reduction in Aβ1−42 vs. a Universal Loss of Aβ Peptides in CSF Differentiates Alzheimer's Disease From Meningitis and Multiple Sclerosis Open
A reduced concentration of Aβ1-42 in CSF is one of the established biomarkers of Alzheimer's disease. Reduced CSF concentrations of Aβ1-42 have also been shown in multiple sclerosis, viral encephalitis and bacterial m…
View article: Mast Cells Are Activated by Streptococcus pneumoniae In Vitro but Dispensable for the Host Defense Against Pneumococcal Central Nervous System Infection In Vivo
Mast Cells Are Activated by Streptococcus pneumoniae In Vitro but Dispensable for the Host Defense Against Pneumococcal Central Nervous System Infection In Vivo Open
Mast cells reside on and near the cerebral vasculature, the predominant site of pneumococcal entry into the central nervous system (CNS). Although mast cells have been reported to be crucial in protecting from systemic bacterial infections…
View article: Inhibition of DAMP signaling as an effective adjunctive treatment strategy in pneumococcal meningitis
Inhibition of DAMP signaling as an effective adjunctive treatment strategy in pneumococcal meningitis Open
View article: Role of purinergic signaling in experimental pneumococcal meningitis
Role of purinergic signaling in experimental pneumococcal meningitis Open
View article: Verteilung und zytotoxische Qualität von T-Zellen und natürlichen Killerzellen im klarzelligen Nierenzellkarzinom
Verteilung und zytotoxische Qualität von T-Zellen und natürlichen Killerzellen im klarzelligen Nierenzellkarzinom Open