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View article: Androgenetic Alopecia and Risks of Overall and Aggressive Prostate Cancer: An Updated Systematic Review and Meta-Analysis
Androgenetic Alopecia and Risks of Overall and Aggressive Prostate Cancer: An Updated Systematic Review and Meta-Analysis Open
Background: Androgenetic alopecia, also known as male pattern baldness (MPB), is a common hair loss disorder among middle-aged men. MPB shares similar risk factors with prostate cancer (PrCa), including advancing age, family history, and s…
View article: Higher aged neutrophils and differential inflammatory profiles in sickle cell disease patients on chronic transfusion therapy versus those on hydroxyurea
Higher aged neutrophils and differential inflammatory profiles in sickle cell disease patients on chronic transfusion therapy versus those on hydroxyurea Open
Background Sickle cell disease (SCD) is characterized by a point mutation in the β globin molecule, causing the sickling of red blood cells, and leading to hemolytic anemia, pain, and end-organ damage. Hydroxyurea (HU) is a cornerstone of …
View article: Anthropometric measures and incidence of obesity-related cancers in the HCHS/SOL Onco-SOL ancillary study
Anthropometric measures and incidence of obesity-related cancers in the HCHS/SOL Onco-SOL ancillary study Open
Obesity is highly prevalent among Hispanic/Latino adults and is an established risk factor for 13 cancers; however, studies focused on Hispanic/Latino adults are limited. We examined six anthropometric measures in association with incidenc…
View article: Anthropometric measures and incidence of obesity-related cancers in the Hispanic Community Health Study/Study of Latinos Onco-SOL ancillary study
Anthropometric measures and incidence of obesity-related cancers in the Hispanic Community Health Study/Study of Latinos Onco-SOL ancillary study Open
Background Obesity is highly prevalent among Hispanic and Latino adults and is an established risk factor for 13 cancers; however, studies focused on Hispanic and Latino adults are limited. We examined 6 anthropometric measures in associat…
View article: Racial Implicit Bias, Treatment Recommendations, and Perceived Compliance in the Care of Juvenile Idiopathic Arthritis
Racial Implicit Bias, Treatment Recommendations, and Perceived Compliance in the Care of Juvenile Idiopathic Arthritis Open
Objective Racial implicit bias may contribute to health disparities in juvenile idiopathic arthritis (JIA) outcomes by impacting provider medical decision‐making. Our study assessed racial and racial–medical compliance implicit biases of a…
View article: Supplementary Table S1 from Cancer Incidence in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)—The Onco-SOL Ancillary Study
Supplementary Table S1 from Cancer Incidence in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)—The Onco-SOL Ancillary Study Open
Supplementary Table S1. All cancers diagnosed in the HCHS/SOL cohort from 2008-2011 through end of follow-up.
View article: Data from Cancer Incidence in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)—The Onco-SOL Ancillary Study
Data from Cancer Incidence in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)—The Onco-SOL Ancillary Study Open
Background:Few studies have examined how cancer incidence varies by the country of origin among US Hispanic/Latino adults. In this study, we describe the incidence rates (IR) of cancer overall and for screen-detectable, tobacco-related, an…
View article: Supplementary Table S2 from Cancer Incidence in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)—The Onco-SOL Ancillary Study
Supplementary Table S2 from Cancer Incidence in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)—The Onco-SOL Ancillary Study Open
Supplementary Table S2. HCHS/SOL weighted cancer incidence hazard ratios (HRs) and 95% confidence intervals (CIs), overall and by sex among those who reported no history of cancer at baseline (n = 15,680).
View article: Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men
Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men Open
Androgenetic alopecia is a highly heritable trait. However, much of our understanding about the genetics of male-pattern baldness comes from individuals of European descent. Here, we examined a dataset comprising 2,136 men from Ghana, Nige…
View article: Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups
Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups Open
View article: Comparisons of Intravesical Treatments with Mitomycin C, Gemcitabine, and Docetaxel for Recurrence and Progression of Non-Muscle Invasive Bladder Cancer: Updated Systematic Review and Meta-Analysis
Comparisons of Intravesical Treatments with Mitomycin C, Gemcitabine, and Docetaxel for Recurrence and Progression of Non-Muscle Invasive Bladder Cancer: Updated Systematic Review and Meta-Analysis Open
Background: Non-muscle-invasive bladder cancer (NMIBC) comprises about 75% of all bladder cancers. Although NMIBC is treatable, it poses significant costs and burdens to patients due to high recurrence rates. We conducted an updated meta-a…
View article: Low-grade Urothelial Carcinoma Recurs at a Tempo that Naturally Accelerates Over Time
Low-grade Urothelial Carcinoma Recurs at a Tempo that Naturally Accelerates Over Time Open
View article: Biparametric versus multiparametric MRI for the detection of clinically significant prostate cancer in a diverse, multiethnic population
Biparametric versus multiparametric MRI for the detection of clinically significant prostate cancer in a diverse, multiethnic population Open
Purpose There is not yet satisfactory performance data comparing multiparametric MRI (mpMRI) versus biparametric MRI (bpMRI) for detecting prostate cancer (PCa), particularly in high-risk populations. We compared both protocols for detecti…
View article: Multinational, Multicenter Evaluation of Prostate Cancer Tissue in Sub-Saharan Africa: Challenges and Opportunities
Multinational, Multicenter Evaluation of Prostate Cancer Tissue in Sub-Saharan Africa: Challenges and Opportunities Open
PURPOSE Prostate cancer disproportionately affects men of African descent, yet their representation in tissue-based studies is limited. This multinational, multicenter pilot study aims to establish the groundwork for collaborative research…
View article: Relationship of regional ultraviolet index data with rash and systemic disease activity in youth with childhood-onset systemic lupus: results from the Childhood Arthritis and Rheumatology Research Alliance Registry
Relationship of regional ultraviolet index data with rash and systemic disease activity in youth with childhood-onset systemic lupus: results from the Childhood Arthritis and Rheumatology Research Alliance Registry Open
View article: Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men
Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men Open
Androgenetic alopecia is a highly heritable trait. However, much of our understanding about the genetics of male pattern baldness comes from individuals of European descent. Here, we examined a novel dataset comprising 2,136 men from Ghana…
View article: Relationship of ultraviolet light exposure and cutaneous and systemic disease activity in youth with childhood-onset systemic lupus: Results from the Childhood Arthritis and Rheumatology Research Alliance Registry
Relationship of ultraviolet light exposure and cutaneous and systemic disease activity in youth with childhood-onset systemic lupus: Results from the Childhood Arthritis and Rheumatology Research Alliance Registry Open
Objective To investigate the association between sun exposure measured by ultraviolet light index (UVI) and seasonality with rash and systemic disease activity in youth with childhood-onset systemic lupus (cSLE) from the Childhood Arthriti…
View article: Assessing frailty in urogynecology patients: a comparative analysis of the Edmonton frail scale and pelvic floor symptom severity
Assessing frailty in urogynecology patients: a comparative analysis of the Edmonton frail scale and pelvic floor symptom severity Open
This study aimed to measure frailty using the Edmonton frail scale (EFS) and examine whether frailty is associated with presenting complaints or worse pelvic floor symptom severity in older urogynecology outpatients. We conducted a cross-s…
View article: Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves cross-ancestry prediction
Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves cross-ancestry prediction Open
We conducted a multi-ancestry genome-wide association study of prostate-specific antigen (PSA) levels in 296,754 men (211,342 European ancestry; 58,236 African ancestry; 23,546 Hispanic/Latino; 3,630 Asian ancestry; 96.5% of participants w…
View article: Heterogeneous genetic architectures and evolutionary genomics of prostate cancer in Sub-Saharan Africa
Heterogeneous genetic architectures and evolutionary genomics of prostate cancer in Sub-Saharan Africa Open
Men of African descent have the highest prostate cancer (CaP) incidence and mortality rates, yet the genetic basis of CaP in African men has been understudied. We used genomic data from 3,963 CaP cases and 3,509 controls recruited in Ghana…
View article: Reduced kidney function and hypertension in adolescents with low birth weight, NHANES 1999–2016
Reduced kidney function and hypertension in adolescents with low birth weight, NHANES 1999–2016 Open
Children born with LBW are at higher risk of reduced kidney function and hypertension than previously described. A higher resolution version of the Graphical abstract is available as Supplementary information.
View article: Data from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa
Data from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa Open
Although prostate cancer is the leading cause of cancer mortality for African men, the vast majority of known disease associations have been detected in European study cohorts. Furthermore, most genome-wide association studies have used ge…
View article: Data from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa
Data from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa Open
Although prostate cancer is the leading cause of cancer mortality for African men, the vast majority of known disease associations have been detected in European study cohorts. Furthermore, most genome-wide association studies have used ge…
View article: Table S1 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa
Table S1 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa Open
Successfully called markers on the MADCaP Array. This tab-delimited file includes genomic positions, inclusion criteria, and overlap with other arrays.
View article: Table S2 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa
Table S2 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa Open
This .xlsx file lists Axiom genotyping solution QC thresholds. Genotyping metrics for both pegs of the MADCaP Array are listed here. This file also includes Benjamini-Hochberg adjusted p-values (FDR = 5%) for pairwise comparisons of derive…
View article: Table S1 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa
Table S1 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa Open
Successfully called markers on the MADCaP Array. This tab-delimited file includes genomic positions, inclusion criteria, and overlap with other arrays.
View article: Figure S1 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa
Figure S1 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa Open
Figure S1. Cross-validation error in ADMIXTURE analyses. The best fit to data occurs at K = 3.
View article: Table S3 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa
Table S3 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa Open
Markers used in PRS calculations. This list includes all markers from the Schumacher et al. 2018 CaP PRS (10) as well as proxy markers that are found on the MADCaP Array. Chromosome and positions (build hg38) listed here are for MADCaP mar…
View article: Figure S1 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa
Figure S1 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa Open
Figure S1. Cross-validation error in ADMIXTURE analyses. The best fit to data occurs at K = 3.
View article: Table S4 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa
Table S4 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa Open
Comprehensive list of cancer-associated loci with African allele frequencies and PBS scores. This dataset includes a total of 2,477 unique markers yielding 3,557 disease or trait associations