Explanipedia

CNSC-81. H3G34-MUTANT DIFFUSE HEMISPHERIC GLIOMAS CONTAIN CELLULAR NICHES OF GABAERGIC INTERNEURON-LIKE CELLS WITH DUAL FREQUENCY AUTONOMOUS RHYTHMIC CALCIUM ACTIVITY Open

Gustavo Alencastro Veiga Cruzeiro, Johann Buhse, Costanza Lo Cascio, Sina Neyazi, Shashank P. Katiyar , et al. · 2025

BACKGROUND Diffuse hemispheric high-grade gliomas with H3G34 mutations (DHG-H3G34) are among the most lethal brain tumors affecting adolescents and young adults. Our recent work revealed that DHG-H3G34 tumors contain cancer cells resemblin…

Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues Open

Maren Salla, Benedikt Obermayer, Michelle G. Cotta, Ekaterina Friebel, Juliana Campo-Garcia , et al. · 2025

High-throughput clonal tracing of primary human samples relies on naturally occurring barcodes, such as somatic mitochondrial DNA (mtDNA) mutations detected via single-cell ATAC-seq (mtscATAC-seq). Fresh-frozen clinical specimens preserve …

Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions Open

Alexander Beck, Lisa Gabler-Pamer, Gustavo Alencastro Veiga Cruzeiro, Sander Lambo, Bernhard Englinger , et al. · 2025

Epidemiology of WHO grade 2 and grade 3 gliomas from 2009 to 2021 in Germany Open

Daniel Weidl, David Capper, Julia Onken, Ilon Liu, Doris Glaser , et al. · 2025

Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure Open

Jenna LaBelle, Rebecca D Haase, Alexander Beck, Jacob Haase, Jiang Li , et al. · 2025

VGLL fusions define a new class of intraparenchymal central nervous system schwannoma Open

Simone Schmid, Kanish Mirchia, Anna Tietze, Ilon Liu, Christin Siewert , et al. · 2024

Background Intracerebral schwannomas are rare tumors resembling their peripheral nerve sheath counterparts but localized in the central nervous system (CNS). They are not classified as a separate tumor type in the 2021 World Health Organiz…

GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant Open

Ilon Liu, Gustavo Alencastro Veiga Cruzeiro, Lynn Bjerke, Rebecca Rogers, Yura Grabovska , et al. · 2024

Diffuse hemispheric gliomas, H3G34R/V-mutant (DHG-H3G34), are lethal brain tumors lacking targeted therapies. They originate from interneuronal precursors; however, leveraging this origin for therapeutic insights remains unexplored. Here, …

CNSC-05. THE GABAERGIC INTERNEURONAL AND NEURAL PROGENITOR LINEAGE OF THE DIFFUSE HEMISPHERIC GLIOMA, H3 G34-MUTANT, SHOW CALCIUM EVENTS IN THE FORM OF INTERCELLULAR WAVES AND SPONTANEOUS ELECTRICAL ACTIVITY Open

Gustavo Alencastro Veiga Cruzeiro, Costanza Lo Cascio, Sina Neyazi, Carlos Alberto Oliveira de Biagi, Rebecca D Haase , et al. · 2024

BACKGROUND High-grade gliomas are one of the deadliest pediatric brain cancers. A diffuse subtype of hemispheric high-grade gliomas in adolescents and young adults is assigned as DHGH3G34-mutant. Notably, DHGH3G34-mutant gliomas distinctiv…

ATRT-09. MULTI-OMICS SEQUENCING OF ATYPICAL TERATOID RHABDOID TUMORS UNVEILS A SHARED GROUND-STATE POPULATION PROMOTING SUBGROUP-SPECIFIC DIFFERENTIATION TRAJECTORIES Open

Enrique Blanco Carmona, Irene Paassen, Jiayou He, Annette Büllesbach, Juliane L. Buhl , et al. · 2024

BACKGROUND Atypical teratoid rhabdoid tumors (ATRTs) remain a significant clinical challenge in pediatric neurooncology. Despite the simplicity of the genomic profile, mostly characterized by the functional loss of SMARCB1 and in rare case…

Diffuse midline glioma invasion and metastasis rely on cell-autonomous signaling Open

Marco Bruschi, Lilia Midjek, Yassine Ajlil, Stéphanie Vairy, Manon Lancien , et al. · 2023

Background Diffuse midline gliomas (DMG) are pediatric tumors with negligible 2-year survival after diagnosis characterized by their ability to infiltrate the central nervous system. In the hope of controlling the local growth and slowing …

HGG-17. SINGLE-CELL AND SPATIAL ANALYSES DECIPHER THE UNIQUE INVASIVE GROWTH PATTERN OF GLIOMATOSIS CEREBRI Open

Shauna Crampsie, Ilon Liu, Lucia Lisa Petrilli, Alan Mackay, Giulio Spinozzi , et al. · 2023

Gliomatosis cerebri (GC) is a rare, lethal glioma that is radiologically diagnosed and characterised by its diffuse infiltration throughout the cerebral lobes of the brain. It is no longer recognised as a separate entity by the WHO classif…

DIPG-08. THE LANDSCAPE OF TUMOR CELL STATES AND SPATIAL ORGANIZATION IN H3-K27M MUTANT DIFFUSE MIDLINE GLIOMA ACROSS AGE AND LOCATION Open

Ilon Liu, Li Jiang, Erik Samuelsson, Sergio Marco Salas, Alexander Beck , et al. · 2023

Histone 3 lysine27-to-methionine mutations (H3-K27M) frequently occur in childhood diffuse midline gliomas (DMGs) of the pons, thalamus, and spinal cord, presumed to be driven by the specific spatiotemporal context of these midline locatio…

DIPG-19. BAF COMPLEX PERTURBATION AS A NOVEL THERAPEUTIC OPPORTUNITY IN H3K27M PEDIATRIC GLIOMA Open

Eshini Panditharatna, Joana G. Marques, Tingjian Wang, Maria Trissal, Ilon Liu , et al. · 2023

Epigenetic dysregulation resulting in stalled development plays a crucial role in pediatric cancer tumorigenesis. Diffuse midline gliomas (DMG) are universally fatal pediatric brain cancers refractory to standard of care treatment modaliti…

ATRT-10. SINGLE-CELL TRANSCRIPTOME ANALYSIS REVEALS CELLULAR HIERARCHIES AND THERAPEUTIC VULNERABILITIES OF ETMR Open

Alexander Beck, Lisa Gabler, Gustavo Alencastro Veiga Cruzeiro, Sander Lambo, Bernhard Englinger , et al. · 2023

Embryonal tumors with multilayered rosettes (ETMR) are malignant brain tumors that occur predominantly in infants and young children. Most patients die within two years of diagnosis, and more effective, targeted therapies are urgently need…

HGG-05. PERTURBING GABAERGIC NEURONAL LINEAGE IN DIFFUSE HEMISPHERIC GLIOMA, H3G34-MUTANT, HIGHLIGHTS CDK6 AS A CLINICALLY ACTIONABLE TARGET Open

Ilon Liu, Gustavo Alencastro Veiga Cruzeiro, Lynn Bjerke, Rebecca Rogers, Yura Grabovska , et al. · 2023

Diffuse hemispheric gliomas, H3G34R/V-mutant (DHG-H3G34), are uniformly lethal malignancies with currently no targeted therapies available. They exclusively occur in the cerebral hemispheres of adolescents and young adults, and have been l…

Supplementary Table from BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma Open

Eshini Panditharatna, Joana G. Marques, Tingjian Wang, Maria Trissal, Ilon Liu , et al. · 2023

Supplementary Table from BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

Supplementary Figure from BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma Open

Eshini Panditharatna, Joana G. Marques, Tingjian Wang, Maria Trissal, Ilon Liu , et al. · 2023

Supplementary Figure from BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma