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View article: 8291316 Aggregate exposure assessment of PFAS in occupational settings: case studies on ski waxers and chemical plant workers
8291316 Aggregate exposure assessment of PFAS in occupational settings: case studies on ski waxers and chemical plant workers Open
View article: Characterization of aggregated exposure to multiple pesticides near agricultural fields: an application of silicone wristbands
Characterization of aggregated exposure to multiple pesticides near agricultural fields: an application of silicone wristbands Open
Public health concerns exist regarding pesticide exposure of workers and residents living near agricultural fields. Still, knowledge is limited in part due to the difficulties of assessing cumulative personal exposure to pesticides over ti…
View article: An Alternative Safety Profiling Algorithm (ASPA) to transform next generation risk assessment into a structured and transparent process
An Alternative Safety Profiling Algorithm (ASPA) to transform next generation risk assessment into a structured and transparent process Open
Next generation risk assessment (NGRA) strategies use animal-free new approach methodologies (NAMs) to generate information concerning chemical hazard, toxicokinetics (ADME), and exposure. The information from these major pillars of data g…
View article: Approaches to identify exposure to real-life chemical mixtures in the general population
Approaches to identify exposure to real-life chemical mixtures in the general population Open
Humans are exposed to large number of chemicals from various sources in their environment. Current risk assessment approaches often focus on single chemicals, sources or routes, not accounting for possible combinations of chemicals and ove…
View article: Urinary pesticide mixture patterns and exposure determinants in the adult population from the Netherlands and Switzerland: Application of a suspect screening approach
Urinary pesticide mixture patterns and exposure determinants in the adult population from the Netherlands and Switzerland: Application of a suspect screening approach Open
High consumption of organic fruit and vegetables was associated with lower pesticide exposure. In the two countries, detection rates and co-occurrence were typically low, and within-person variability was high. Our study results provide an…
View article: Cumulative risk assessment of exposure to a mixture of pesticides among Czech adults and children from the CELSPAC-SPECIMEn cohort
Cumulative risk assessment of exposure to a mixture of pesticides among Czech adults and children from the CELSPAC-SPECIMEn cohort Open
BACKGROUND AND AIM: Current-use pesticides (CUP) are extensively applied in both agricultural and urban settings. Exposure occurs mainly via the dietary pathway; however, other pathways such as inhalation or skin contact are also important…
View article: Identification of Real-Life Mixtures Using Human Biomonitoring Data: A Proof of Concept Study
Identification of Real-Life Mixtures Using Human Biomonitoring Data: A Proof of Concept Study Open
Human health risk assessment of chemical mixtures is complex due to the almost infinite number of possible combinations of chemicals to which people are exposed to on a daily basis. Human biomonitoring (HBM) approaches can provide inter al…
View article: Mixture risk assessment and human biomonitoring: Lessons learnt from HBM4EU
Mixture risk assessment and human biomonitoring: Lessons learnt from HBM4EU Open
View article: Effects of pesticide exposure on oxidative stress and DNA methylation urinary biomarkers in Czech adults and children from the CELSPAC-SPECIMEn cohort
Effects of pesticide exposure on oxidative stress and DNA methylation urinary biomarkers in Czech adults and children from the CELSPAC-SPECIMEn cohort Open
View article: Assessment of exposure to pesticide mixtures in five European countries by a harmonized urinary suspect screening approach
Assessment of exposure to pesticide mixtures in five European countries by a harmonized urinary suspect screening approach Open
View article: Effect of pesticides exposure on oxidative stress and epigenetic changes biomarkers in Czech adults and children from the CELSPAC-SPECIMEn cohort
Effect of pesticides exposure on oxidative stress and epigenetic changes biomarkers in Czech adults and children from the CELSPAC-SPECIMEn cohort Open
BACKGROUND AND AIM: Pesticides exposure occurs through diet and environmental application readily in both agricultural and urban settings. While pesticides exposure has been associated with many health effects, the question of the adverse …
View article: A large scale multi-laboratory suspect screening of pesticide metabolites in human biomonitoring: From tentative annotations to verified occurrences
A large scale multi-laboratory suspect screening of pesticide metabolites in human biomonitoring: From tentative annotations to verified occurrences Open
View article: Pesticide exposure among Czech adults and children from the CELSPAC-SPECIMEn cohort: Urinary biomarker levels and associated health risks
Pesticide exposure among Czech adults and children from the CELSPAC-SPECIMEn cohort: Urinary biomarker levels and associated health risks Open
View article: A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data
A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data Open
Pyrethroids are a major insecticide class, suitable for biomonitoring in humans. Due to similarities in structure and metabolic pathways, urinary metabolites are common to various active substances. A tiered approach is proposed for risk a…
View article: D15.6 - Results of the joint survey on HBM mixtures
D15.6 - Results of the joint survey on HBM mixtures Open
This deliverable describes the results of the joint pesticide survey ’SPECIMEn’ in five partner countries: Czech Republic, Hungary, Latvia, Spain and the Netherlands. It also contains a report on the implementation of a study conducted in …
View article: D15.7 - Report on re-analysis of existing HBM data for priority substances to identify mixtures
D15.7 - Report on re-analysis of existing HBM data for priority substances to identify mixtures Open
This report describes the results obtained using network analysis in combination with human biomonitoring data, with the aim to identify real-life mixtures. Network analyses applied to existing Human Biomonitoring data allow for the ident…
View article: D15.8 - Lessons-learnt from HBM4EU WP15 on mixtures: intermediate recommendations
D15.8 - Lessons-learnt from HBM4EU WP15 on mixtures: intermediate recommendations Open
Within HBM4EU, various approaches to improve current procedures for mixture risk assessment have been investigated. Based on the insights and lessons learnt in the context of HBM4EU, conclusions as well as recommendations for risk asse…
View article: Network Analysis to Identify Communities Among Multiple Exposure Biomarkers Measured at Birth in Three Flemish General Population Samples
Network Analysis to Identify Communities Among Multiple Exposure Biomarkers Measured at Birth in Three Flemish General Population Samples Open
Introduction: Humans are exposed to multiple environmental chemicals via different sources resulting in complex real-life exposure patterns. Insight into these patterns is important for applications such as linkage to health effects and (m…
View article: AD15.7 - Joint survey of pesticides: details of approach and contributions
AD15.7 - Joint survey of pesticides: details of approach and contributions Open
The HBM4EU joint survey of pesticides, 'Survey on PEstiCIde Mixtures in Europe', was carried out in five partner countries: Czech Republic, Hungary, Latvia, Spain and the Netherlands. They jointly developed the details of the work protocol…
View article: AD15.1 - Plan for development of case studies
AD15.1 - Plan for development of case studies Open
This deliverable describes the HBM4EU activities leading up to the development of case studies for mixture health effects and outlines the proposed case studies. The addendum provides further details about multi-year perspective and timin…
View article: D15.3 - Report real-life exposure profiles from re-analysis of existing HBM mixture data
D15.3 - Report real-life exposure profiles from re-analysis of existing HBM mixture data Open
<p>This deliverable describes several statistical approaches that provide insights into real-life mixtures. In addition, it provides statistical methods that can be used to gain insight into the determinants of mixture profiles in HB…
View article: Knowledge and awareness of health effects related to the use of mercury in artisanal and small-scale gold mining in Suriname
Knowledge and awareness of health effects related to the use of mercury in artisanal and small-scale gold mining in Suriname Open
The implementation of a health education programme within an existing local healthcare structure proved effective and levels of knowledge and awareness improved. Most improved was the knowledge on health effects attributable to mercury, mo…
View article: Plan for development of case studies - Deliverable Report AD 15.1 WP 15 - Mixtures, HBM and human health risk
Plan for development of case studies - Deliverable Report AD 15.1 WP 15 - Mixtures, HBM and human health risk Open
This deliverable describes the activities in task 15.3 leading up to the development of cases studies for mixture health effects and outlines the proposed case studies. The proposed case studies are: · Developmental neurotoxicity beyond po…
View article: AD15.3 - HBM mixture database description and proposal statistical analysis plan
AD15.3 - HBM mixture database description and proposal statistical analysis plan Open
This deliverable focuses on preparatory ground work associated with the work on the identification of real-life mixtures using HBM data. Activities include the description of a functional database structure, development of a statistical an…
View article: Assessment of Determinants of Emission Potentially Affecting the Concentration of Airborne Nano-Objects and Their Agglomerates and Aggregates
Assessment of Determinants of Emission Potentially Affecting the Concentration of Airborne Nano-Objects and Their Agglomerates and Aggregates Open
These results give an indication of the direction and magnitude of the effect of the studied determinants on concentrations close to the source and provide a scientific basis for (further) development of existing and future NOAA inhalation…