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View article: Leptin engages the lateral hypothalamus to ventral tegmental area circuit to modulate sleep-wake behavior
Leptin engages the lateral hypothalamus to ventral tegmental area circuit to modulate sleep-wake behavior Open
Sleep and metabolism are inextricably linked and mutually affect each other. Leptin is a pivotal regulator of metabolic homeostasis, but its effect on sleep-wake regulation remains elusive. Here we demonstrate that leptin acts on a small s…
View article: Opioidergic signaling contributes to food-mediated suppression of AgRP neurons
Opioidergic signaling contributes to food-mediated suppression of AgRP neurons Open
Opioids are generally known to promote hedonic food consumption. Although much of the existing evidence is primarily based on studies of the mesolimbic pathway, endogenous opioids and their receptors are widely expressed in hypothalamic ap…
View article: Supplementary Material for: MCH Neuron Activity Is Sufficient for Reward and Reinforces Feeding
Supplementary Material for: MCH Neuron Activity Is Sufficient for Reward and Reinforces Feeding Open
Background: Melanin-concentrating hormone (MCH)-expressing neurons have been implicated in regulation of energy homeostasis and reward, yet the role of their electrical activity in short-term appetite and reward modulation has not been ful…
View article: Impaired melanocortin pathway function in Prader–Willi syndrome gene-Magel2 deficient mice
Impaired melanocortin pathway function in Prader–Willi syndrome gene-Magel2 deficient mice Open
Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder causing social and learning deficits, impaired satiety and severe childhood obesity. Genetic underpinning of PWS involves deletion of a chromosomal region with several genes, inc…