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2891. Nebulized Phage Therapy for Patients with Cystic Fibrosis with Chronic <i>Pseudomonas aeruginosa</i> Pulmonary Infection: A Phase 1b/2a Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Open

Urania Rappo, Ariel Cohen, Edith Kario, Jenia Gold, Hadas Nevenzal , et al. · 2023

Background Pseudomonas aeruginosa (PsA) continues to cause difficult-to-treat pulmonary infections and hospitalizations in patients with cystic fibrosis (CF). Safer and targeted therapies are needed to minimize the morbidity and disease bu…

Sequence determinants of polyadenylation-mediated regulation Open

Ilya Vainberg Slutskin, Adina Weinberger, Eran Segal · 2019

The cleavage and polyadenylation reaction is a crucial step in transcription termination and pre-mRNA maturation in human cells. Despite extensive research, the encoding of polyadenylation-mediated regulation of gene expression within the …

Unraveling the determinants of microRNA mediated regulation using a massively parallel reporter assay Open

Ilya Vainberg Slutskin, Shira Weingarten-Gabbay, Ronit Nir, Adina Weinberger, Eran Segal · 2018

Corrigendum: TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code Open

Modi Safra, Ronit Nir, Daneyal Farouq, Ilya Vainberg Slutskin, Schraga Schwartz · 2017

TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code Open

Modi Safra, Ronit Nir, Daneyal Farouq, Ilya Vainberg Slutskin, Schraga Schwartz · 2017

Following synthesis, RNA can be modified with over 100 chemically distinct modifications, which can potentially regulate RNA expression post-transcriptionally. Pseudouridine (Ψ) was recently established to be widespread and dynamically reg…

Massively Parallel Interrogation of the Effects of Gene Expression Levels on Fitness Open

Leeat Keren, Jean Hausser, Maya Lotan‐Pompan, Ilya Vainberg Slutskin, Hadas Alisar , et al. · 2016

Pyruvate Formate-Lyase Enables Efficient Growth of <i>Escherichia coli</i> on Acetate and Formate Open

Lior Zelcbuch, Steffen N. Lindner, Yonatan Zegman, Ilya Vainberg Slutskin, Niv Antonovsky , et al. · 2016

Pyruvate formate-lyase (PFL) is a ubiquitous enzyme that supports increased ATP yield during sugar fermentation. While the PFL reaction is known to be reversible in vitro, the ability of PFL to support microbial growth by condensing acetyl…

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