Explanipedia

Neuroinflammatory Consequences of Rhinovirus Infection in Human Epithelial and Neuronal Models Open

Orla M. Dunne, Nicola A. M. Roe, Aurélie Mousnier, Lorraine Martin, Gerard P. Sergeant , et al. · 2025

Introduction Rhinovirus (RV) is the leading cause of exacerbations of lung disease. A sensory neuronal model, derived from human dental pulp stem cells and differentiated into peripheral neuronal equivalents (PNEs), was used to examine RV’…

Neuroinflammatory Consequences of Rhinovirus Infection in Human Epithelial and Neuronal Models Open

Nicola A. M. Roe, Orla M. Dunne, Aurélie Mousnier, Lorraine Martin, Gerard P. Sergeant , et al. · 2025

Introduction: Rhinovirus (RV) is the leading cause of exacerbations of lung disease. A sensory neuronal model, derived from human dental pulp stem cells and differentiated into peripheral neuronal equivalents (PNEs), was used to examine RV…

Complement C5a Implication in Axonal Growth After Injury Open

Aurélie Cotten, Charlotte Jeanneau, Patrick Decherchi, Imad About · 2024

Complement C5a protein has been shown to play a major role in tissue regeneration through interaction with its receptor (C5aR) on target cells. Expression of this receptor has been reported in the nervous system which, upon injury, has no …

Immunological isolation and characterization of neuronal progenitors from human dental pulp: A laboratory‐based investigation Open

Hayley McMillan, Fionnuala T. Lundy, Orla M. Dunne, Kiran J. McLoughlin, Imad About , et al. · 2024

Aims Dental pulp stem cells (DPSCs) contain a population of stem cells with a broad range of differentiation potentials, as well as more lineage‐committed progenitors. Such heterogeneity is a significant obstacle to experimental and clinic…

The Added Value of a Collagenated Thermosensitive Bone Substitute as a Scaffold for Bone Regeneration Open

Charlotte Jeanneau, Jean‐Hugues Catherine, Thomas Giraud, Romain Lan, Imad About · 2024

A pre-hydrated thermosensitive collagenated biomaterial which sets at body temperature and maintains the space of the missing alveolar bone volume, OsteoBiol GTO® (GTO), has been released as a bone substitute. This study was designed to ch…

Osteogenic Potential of a Polyethylene Glycol Hydrogel Functionalized with Poly-Lysine Dendrigrafts (DGL) for Bone Regeneration Open

Sandra Roumani, Charlotte Jeanneau, Thomas Giraud, Aurélie Cotten, Marc Laucournet , et al. · 2023

Resorbable hydrogels are widely used as scaffolds for tissue engineering. These hydrogels can be modified by grafting dendrimer-linked functionalized molecules (dendrigrafts). Our aim was to develop a tunable poly(L-lysine) dendrigrafts (D…

Regulation of caries‐induced pulp inflammation by NLRP3 inflammasome: A laboratory‐based investigation Open

Banan Al Natour, Fionnuala T. Lundy, Imad About, Charlotte Jeanneau, Yvonne Dombrowski , et al. · 2022

Aim To evaluate the expression and function of the nod‐like receptor pyrin domain containing 3 (NLRP3) inflammasome in caries induced pulpitis. Methodology NLRP3 expression was determined with immunohistochemistry in the dental pulp and qP…

Nanoarchitectonics of Electrically Activable Phosphonium Self-Assembled Monolayers to Efficiently Kill and Tackle Bacterial Infections on Demand Open

Serena Carrara, Florent Rouvier, Sanjana Auditto, Frédéric F. Brunel, Charlotte Jeanneau , et al. · 2022

Prosthetic implants are widely used in dentistry and orthopedics and as a result, infections can occur causing their removal.It is therefore essential to propose methods of eradicating the bacteria that remain on the prosthesis during trea…

Novel Antibacterial Properties of the Human Dental Pulp Multipotent Mesenchymal Stromal Cell Secretome Open

Harriet Ravenscroft, Ikhlas El Karim, Anna Krasnodembskaya, Brendan Gilmore, Imad About , et al. · 2022

It is well recognized that clearance of bacterial infection within the dental pulp precedes pulpal regeneration. However, although the regenerative potential of the human dental pulp has been investigated extensively, its antimicrobial pot…

Nanoarchitectonics of Electrically Activable Phosphonium Self-Assembled Monolayers to Efficiently Kill and Tackle Bacterial Infections on Demand Open

Serena Carrara, Florent Rouvier, Sanjana Auditto, Frédéric Brunel, Charlotte Jeanneau , et al. · 2022

Prosthetic implants are widely used in dentistry and orthopedics and, as a result, infections can occur which cause their removal. Therefore, it is essential to propose methods of eradicating the bacteria that remain on the prosthesis duri…

Multicomponent Peptide Hydrogels as an Innovative Platform for Cell-Based Tissue Engineering in the Dental Pulp Open

Marina Afami, Ikhlas El Karim, Imad About, Anna Krasnodembskaya, Garry Laverty , et al. · 2021

In light of the increasing levels of antibiotic resistance, nanomaterials and novel biologics are urgently required to manage bacterial infections. To date, commercially available self-assembling peptide hydrogels have not been studied ext…

Fibroblasts Control Macrophage Differentiation during Pulp Inflammation Open

Chloé Le Fournis, Charlotte Jeanneau, Thomas Giraud, Ikhlas El Karim, Fionnuala T. Lundy , et al. · 2021

Identification and validation of novel biomarkers and therapeutics for pulpitis using connectivity mapping Open

Banan Al‐Natour, R. Rankin, Robyn McKenna, Hayley McMillan, S. D. Zhang , et al. · 2021

Aim To create an irreversible pulpitis gene signature from microarray data of healthy and inflamed dental pulps, followed by a bioinformatics approach using connectivity mapping to identify therapeutic compounds that could potentially trea…

Ultrashort Peptide Hydrogels Display Antimicrobial Activity and Enhance Angiogenic Growth Factor Release by Dental Pulp Stem/Stromal Cells Open

Marina Afami, Ikhlas El Karim, Imad About, Sophie Coulter, Garry Laverty , et al. · 2021

Recent studies on peptide hydrogels have shown that ultrashort peptides (<8 amino acids) can self-assemble into hydrogels. Ultrashort peptides can be designed to incorporate antimicrobial motifs, such as positively charged lysine residues,…

Deciphering Reparative Processes in the Inflamed Dental Pulp Open

Ikhlas El Karim, Paul R. Cooper, Imad About, Phillip L. Tomson, Fionnuala T. Lundy , et al. · 2021

Research over several decades has increased our understanding of the nature of reparative and regenerative processes in the dental pulp, at both the cellular and molecular level. However, advances in scientific knowledge have not translate…

Endogenous Mas‐related G‐protein‐coupled receptor X1 activates and sensitizes TRPA1 in a human model of peripheral nerves Open

Hayley McMillan, Fionnuala T. Lundy, Orla M. Dunne, Banan Al‐Natour, Charlotte Jeanneau , et al. · 2021

Mas‐related G‐protein‐coupled receptor X1 (MrgprX1) is a human‐specific Mrgpr and its expression is restricted to primary sensory neurons. However, its role in nociception and pain signaling pathways is largely unknown. This study aims to …

Biocompatibility assessment of resin-based cements on vascularized dentin/pulp tissue-engineered analogues Open

Christina Hadjichristou, Eleni Papachristou, Emmanouil Vereroudakis, Μaria Chatzinikolaidou, Imad About , et al. · 2021

Odontoblast cell death induces NLRP3 inflammasome‐dependent sterile inflammation and regulates dental pulp cell migration, proliferation and differentiation Open

Banan Al Natour, Fionnuala T. Lundy, P. N. Moynah, Imad About, C. Jeanneau , et al. · 2021

Aim To investigate the ability of dead odontoblasts to initiate NLRP3 inflammasome‐dependent sterile inflammation and to explore the effect on dental pulp cell (DPCs) migration, proliferation and odontogenic differentiation. Methods Odonto…

Advanced in Vitro Experimental Models for Tissue Engineering-based Reconstruction of a 3D Dentin/pulp Complex: a Literature Review Open

Christina Hadjichristou, Imad About, Petros Koidis, Athina Bakopoulou · 2020

Complement activation links inflammation to dental tissue regeneration Open

Madison Bergmann, Charlotte Jeanneau, Thomas Giraud, Gilles Richard, Imad About · 2020

Pulp Fibroblast Contribution to the Local Control of Pulp Inflammation via Complement Activation Open

Chloé Le Fournis, Charlotte Jeanneau, Sandra Roumani, Thomas Giraud, Imad About · 2020

Proceedings of the Pulp Biology and Regeneration Group Symposium 2019: Bridging Basic and Translational Research in Pulp Biology—Developing Technologies for Regenerating Vital Dental Tissues Open

Imad About · 2020

Table of Contents Open

Imad About, Fionnuala T. Lundy, Christopher Irwin, Donna McLean, Gerard J. Linden , et al. · 2020

Conservative Management of Mature Permanent Teeth with Carious Pulp Exposure Open

Nessrin A. Taha, Imad About, Christine Sedgley, Harold H. Messer · 2020

Preclinical effectiveness of an experimental tricalcium silicate cement on pulpal repair Open

Xin Li, Mariano Simón Pedano, Shuchen Li, Zheyi Sun, Charlotte Jeanneau , et al. · 2020

A connectivity mapping approach predicted acetylsalicylic acid (aspirin) to induce osteo/odontogenic differentiation of dental pulp cells Open

R. Rankin, Fionnuala T. Lundy, Bettina Schock, S.‐D. Zhang, Banan Al‐Natour , et al. · 2020

Aim To use connectivity mapping, a bioinformatics approach, to identify compounds that could induce odontogenic differentiation of dental pulp cells (DPCs) and to experimentally validate this effect. A subsidiary aim was to investigate the…

BioRoot™ RCS modulates the initial steps of inflammation and regeneration Open

Charlotte Jeanneau, Tatiana Giraud, Patrick Laurent, Imad About · 2020

Xenogeneic bone filling materials modulate mesenchymal stem cell recruitment: role of the Complement C5a Open

Charlotte Jeanneau, Chloé Le Fournis, Imad About · 2019

BioRoot RCS Extracts Modulate the Early Mechanisms of Periodontal Inflammation and Regeneration Open

Charlotte Jeanneau, Thomas Giraud, Patrick Laurent, Imad About · 2019

Investigating unset endodontic sealers’ eugenol and hydrocortisone roles in modulating the initial steps of inflammation Open

Charlotte Jeanneau, Thomas Giraud, Jean‐Louis Milan, Imad About · 2019

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