Imayavaramban Lakshmanan
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View article: FOXM1 targeting alters AURKB activity and reshapes antitumor immunity to curb the progression of small cell lung cancer
FOXM1 targeting alters AURKB activity and reshapes antitumor immunity to curb the progression of small cell lung cancer Open
Small cell lung cancer (SCLC) is a lethal lung malignancy which is associated with distant metastasis and chemoresistance. Limited targeted therapies further worsen disease outcomes. Single-cell and bulk RNA-sequencing (RNA-seq) datasets w…
View article: FOXM1 targeting alters AURKB activity and reshapes antitumor immunity to curb the progression of small cell lung cancer
FOXM1 targeting alters AURKB activity and reshapes antitumor immunity to curb the progression of small cell lung cancer Open
Background Small cell lung cancer (SCLC) is a lethal lung malignancy and patients are often diagnosed with distant metastasis. Nearly all patients suffer from disease relapsing with inherent chemoresistance. Lack of targeted SCLC therapies…
View article: ST6GalNAc-I regulates tumor cell sialylation via NECTIN2/MUC5AC-mediated immunosuppression and angiogenesis in non–small cell lung cancer
ST6GalNAc-I regulates tumor cell sialylation via NECTIN2/MUC5AC-mediated immunosuppression and angiogenesis in non–small cell lung cancer Open
Glycosylation controls immune evasion, tumor progression, and metastasis. However, how tumor cell sialylation regulates immune evasion remains poorly characterized. ST6GalNAc-I, a sialyltransferase that conjugates sialic acid to the glycan…
View article: Supplementary Figure S5 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S5 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 5. MUC5AC silencing inhibits cMET and CD44v6 expression and Astrocytes induce MUC5AC expression in breast cancer cells. A-B. Western blots showing knockdown of MUC5AC in MDA-231BR HER2 (A) and MUC5AC knockout in HCC195…
View article: Supplementary Figure S6 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S6 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 6. PLB1001 inhibit cMET and CD44v6 expression. A. Representative IHC images showing MUC5AC expression in G5-3 PDXs B. Representative fluorescence microscopy images showing GFP+ in G5-3 PDXs C. Representative IHC images…
View article: Supplementary Figure S4 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S4 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 4. MUC5AC silencing inhibits brain metastasis. A. Fluorescence microscopy images showing Cytokeratin 8/18 and MUC5AC in the brain tissue sections of the mice intracardially injected with shSCR and shMUC5AC KD MDA-231BR…
View article: Data from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Data from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Purpose:Breast cancer brain metastasis remains a significant clinical problem. Mucins have been implicated in metastasis; however, whether they are also involved in breast cancer brain metastasis remains unknown. We queried databases of pa…
View article: Supplementary Figure S1 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S1 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 1. Expression of MUC5AC is high in breast cancer brain metastasis. A. Heatmap showing the expression of upregulated genes in BC BrM cells as compared to primary BC cells (MDA-231BR vs MDA-231P). B. Comparison of MUC5AC…
View article: Supplementary Figure S2 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S2 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 2. MUC5AC IHC staining using Aperio Digital Imaging revealed MUC5AC strong to medium scores in BrM patient samples. Tumor areas were defined by annotations (green color) and necrotic areas or areas not corresponding to…
View article: Supplementary Figure S3 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S3 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 3. MUC5AC promotes brain metastasis. A. Western blot for HER2 expression in MDA-231BR HER2 cells. B. Western blot showing knockout of MUC5AC in the HCC1954BR cells. C-F. Wound healing assay and quantification showing r…
View article: Dissecting the MUC5AC/ANXA2 signaling axis: implications for brain metastasis in lung adenocarcinoma
Dissecting the MUC5AC/ANXA2 signaling axis: implications for brain metastasis in lung adenocarcinoma Open
Non-small cell lung carcinoma (NSCLC) exhibits a heightened propensity for brain metastasis, posing a significant clinical challenge. Mucin 5ac (MUC5AC) plays a pivotal role in the development of lung adenocarcinoma (LUAD); however, its ro…
View article: Chimeric antibody targeting unique epitope on onco-mucin16 reduces tumor burden in pancreatic and lung malignancies
Chimeric antibody targeting unique epitope on onco-mucin16 reduces tumor burden in pancreatic and lung malignancies Open
View article: Data from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
Data from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer, as it commonly metastasizes to the liver resulting in an overall poor prognosis. However, the molecular mechanism involved in liver metastasis remains poorl…
View article: Supplementary Table from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
Supplementary Table from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion Open
Supplementary Table from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
View article: Supplementary Figure from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
Supplementary Figure from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion Open
Supplementary Figure from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
View article: Supplementary Figure from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
Supplementary Figure from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion Open
Supplementary Figure from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
View article: Supplementary Table from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
Supplementary Table from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion Open
Supplementary Table from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
View article: Data from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
Data from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer, as it commonly metastasizes to the liver resulting in an overall poor prognosis. However, the molecular mechanism involved in liver metastasis remains poorl…
View article: Supplementary Fig. 2 from MUC4-Mediated Regulation of Acute Phase Protein Lipocalin 2 through HER2/AKT/NF-κB Signaling in Pancreatic Cancer
Supplementary Fig. 2 from MUC4-Mediated Regulation of Acute Phase Protein Lipocalin 2 through HER2/AKT/NF-κB Signaling in Pancreatic Cancer Open
PDF file 130K, Inhibition of lipocalin 2 by Bay11-7082
View article: Supplementary Revised Figure S1 from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53
Supplementary Revised Figure S1 from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53 Open
MUC16 incidence in lung cancer. A, MUC16 is overexpressed in a greater proportion of lung adenocarcinoma compared to other histological subtypes. B, Data from TCGA also shows that MUC16 is highly expressed in adenocarcinoma tissues than sq…
View article: Supplementary Revised Figure S3 from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53
Supplementary Revised Figure S3 from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53 Open
Chemoresistance properties of MUC16 and effect of cisplatin on apoptosis of MUC16 knockdown cells. A & B, MUC16 knockdown (H1975-shMUC16 seq1 and 2) cells were highly sensitive to cisplatin (A) and gemcitabine (B). C, The percentage of apo…
View article: Supplementary Information from MUC4-Mediated Regulation of Acute Phase Protein Lipocalin 2 through HER2/AKT/NF-κB Signaling in Pancreatic Cancer
Supplementary Information from MUC4-Mediated Regulation of Acute Phase Protein Lipocalin 2 through HER2/AKT/NF-κB Signaling in Pancreatic Cancer Open
PDF file 98K, Supplementary Methodology
View article: Supplementary Revised Figure S2 from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53
Supplementary Revised Figure S2 from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53 Open
Pharmacological inhibition of phospho JAK1/2 in lung cancer cells. A, Upon JAK1/2 inhibition by ruxolitinib, we observed decreased phosphorylation of STAT3 (Y705) but no change in STAT3 expression. B, Similar effect was also observed in MU…
View article: Data from MUC4-Mediated Regulation of Acute Phase Protein Lipocalin 2 through HER2/AKT/NF-κB Signaling in Pancreatic Cancer
Data from MUC4-Mediated Regulation of Acute Phase Protein Lipocalin 2 through HER2/AKT/NF-κB Signaling in Pancreatic Cancer Open
Purpose: MUC4 shows aberrant expression in early pancreatic lesions and a high specificity for pancreatic cancer. It thus has a high potential to be a sensitive and specific biomarker. Unfortunately, its low serum level limits its d…
View article: Supplementary Figure legends from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53
Supplementary Figure legends from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53 Open
Supplementary Figure legends
View article: Data from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53
Data from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53 Open
Purpose: MUC16, a tumor biomarker and cell surface–associated mucin, is overexpressed in various cancers; however, its role in lung cancer pathogenesis is unknown. Here, we have explored the mechanistic role of MUC16 in lung cancer.…
View article: Supplementary Figure legends from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53
Supplementary Figure legends from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53 Open
Supplementary Figure legends
View article: Supplementary Revised Figure S3 from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53
Supplementary Revised Figure S3 from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53 Open
Chemoresistance properties of MUC16 and effect of cisplatin on apoptosis of MUC16 knockdown cells. A & B, MUC16 knockdown (H1975-shMUC16 seq1 and 2) cells were highly sensitive to cisplatin (A) and gemcitabine (B). C, The percentage of apo…
View article: Supplementary Revised Figure S1 from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53
Supplementary Revised Figure S1 from MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53 Open
MUC16 incidence in lung cancer. A, MUC16 is overexpressed in a greater proportion of lung adenocarcinoma compared to other histological subtypes. B, Data from TCGA also shows that MUC16 is highly expressed in adenocarcinoma tissues than sq…
View article: Supplementary Fig. 1 from MUC4-Mediated Regulation of Acute Phase Protein Lipocalin 2 through HER2/AKT/NF-κB Signaling in Pancreatic Cancer
Supplementary Fig. 1 from MUC4-Mediated Regulation of Acute Phase Protein Lipocalin 2 through HER2/AKT/NF-κB Signaling in Pancreatic Cancer Open
PDF file 89K, Effect of lipocalin 2 on MUC4 expression in pancreatic cancer cell lines