Immanuel Dhanasingh
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View article: An update on thermostable keratinases for protein engineering against feather pollutants
An update on thermostable keratinases for protein engineering against feather pollutants Open
View article: Molecular docking, validation, dynamic simulation and pharmacokinetic prediction of natural compounds against <i>Mycobacterium tuberculosis</i> Beta-lactamase BlaC
Molecular docking, validation, dynamic simulation and pharmacokinetic prediction of natural compounds against <i>Mycobacterium tuberculosis</i> Beta-lactamase BlaC Open
Tuberculosis, caused by Mycobacterium tuberculosis ranks second globally in terms of infectious disease-related deaths, after HIV. The resistance of M. tuberculosis to existing beta-lactam antibiotics is primarily due to chromosomally enco…
View article: IN-SILICOIDENTIFICATION OF FLAVONOIDS BASED INHIBITORS AGAINST SORTASE-A FROM ENTEROCOCCUS FAECALIS (Ef)
IN-SILICOIDENTIFICATION OF FLAVONOIDS BASED INHIBITORS AGAINST SORTASE-A FROM ENTEROCOCCUS FAECALIS (Ef) Open
The enzyme known as SortaseA(SrtA) is widespread present in gram-positive bacteria. SrtA is responsible for anchoring a large number of surface protein virulence factors to the cell wall. This enzyme is not involved in bacterial growth and…
View article: Correlating the differences in the receptor binding domain of SARS-CoV-2 spike variants on their interactions with human ACE2 receptor
Correlating the differences in the receptor binding domain of SARS-CoV-2 spike variants on their interactions with human ACE2 receptor Open
View article: A missense variant in SHARPIN mediates Alzheimer’s disease-specific brain damages
A missense variant in SHARPIN mediates Alzheimer’s disease-specific brain damages Open
View article: Functional Characterization of Primordial Protein Repair Enzyme M38 Metallo-Peptidase From Fervidobacterium islandicum AW-1
Functional Characterization of Primordial Protein Repair Enzyme M38 Metallo-Peptidase From Fervidobacterium islandicum AW-1 Open
The NA23_RS08100 gene of Fervidobacterium islandicum AW-1 encodes a keratin-degrading β-aspartyl peptidase ( Fi BAP) that is highly expressed under starvation conditions. Herein, we expressed the gene in Escherichia coli , purified the rec…
View article: The sulfur formation system mediating extracellular cysteine‐cystine recycling in <i>Fervidobacterium islandicum</i> AW‐1 is associated with keratin degradation
The sulfur formation system mediating extracellular cysteine‐cystine recycling in <i>Fervidobacterium islandicum</i> AW‐1 is associated with keratin degradation Open
Summary Most extremophilic anaerobes possess a sulfur formation (Suf) system for Fe–S cluster biogenesis. In addition to its essential role in redox chemistry and stress responses of Fe–S cluster proteins, the Suf system may play an import…
View article: Non-catalytic-Region Mutations Conferring Transition of Class A β-Lactamases Into ESBLs
Non-catalytic-Region Mutations Conferring Transition of Class A β-Lactamases Into ESBLs Open
Despite class A ESBLs carrying substitutions outside catalytic regions, such as Cys69Tyr or Asn136Asp, have emerged as new clinical threats, the molecular mechanisms underlying their acquired antibiotics-hydrolytic activity remains unclear…
View article: Crystal structure of Cytochrome <i>c</i>L from the aquatic methylotrophic bacterium <i>Methylophaga</i> <i>aminisulfidivorans</i> MP<sup>T</sup>
Crystal structure of Cytochrome <i>c</i>L from the aquatic methylotrophic bacterium <i>Methylophaga</i> <i>aminisulfidivorans</i> MP<sup>T</sup> Open
Cytochrome cL (CytcL) is an essential protein in the process of methanol oxidation in methylotrophs. It receives an electron from the pyrroloquinoline quinone (PQQ) cofactor of methanol dehydrogenase (MD…
View article: Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma
Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma Open
The non-receptor cytoplasmic tyrosine kinase, Focal Adhesion Kinase (FAK) is known to play a key role in a variety of normal and cancer cellular functions such as survival, proliferation, migration and invasion. It is highly active and ove…
View article: PI3 Kinase Pathway and MET Inhibition is Efficacious in Malignant Pleural Mesothelioma
PI3 Kinase Pathway and MET Inhibition is Efficacious in Malignant Pleural Mesothelioma Open
View article: <i>C. elegans</i>and mutants with chronic nicotine exposure as a novel model of cancer phenotype
<i>C. elegans</i>and mutants with chronic nicotine exposure as a novel model of cancer phenotype Open
We previously investigated MET and its oncogenic mutants relevant to lung cancer in C. elegans. The inactive orthlogues of the receptor tyrosine kinase Eph and MET, namely vab-1 and RB2088 respectively, the temperature sensitive constituti…