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View article: An interactive database containing all known variants in ADAMTS13 yields new insight into the genetic variation and protein changes underlying congenital TTP
An interactive database containing all known variants in ADAMTS13 yields new insight into the genetic variation and protein changes underlying congenital TTP Open
Introduction A disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13 (ADAMTS13) is encoded by a 45kb gene on chromosome 9q34.2. Deficiency leads to Thrombotic Thrombocytopenic Purpura (TTP), which exists as immune T…
View article: Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2
Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2 Open
The Omicron strains of SARS-CoV-2 pose a significant challenge to the development of effective antibody-based treatments as immune evasion has compromised most available immune therapeutics. Therefore, in the ‘arms race’ with the virus, th…
View article: From Llama to Nanobody: A Streamlined Workflow for the Generation of Functionalised VHHs
From Llama to Nanobody: A Streamlined Workflow for the Generation of Functionalised VHHs Open
Nanobodies are recombinant antigen-specific single domain antibodies (VHHs) derived from the heavy chain–only subset of camelid immunoglobulins. Their small molecular size, facile expression, high affinity, and stability have combined to m…