Maria Regina D’Império Lima
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View article: P2RX7 regulates lung immune responses to allergens in a sensitization route-dependent way 2955
P2RX7 regulates lung immune responses to allergens in a sensitization route-dependent way 2955 Open
Description Immune responses to allergens vary depending on the route of sensitization, but the mechanisms behind these differences are not clear. Damage signals from the microenvironment dictate the immune response magnitude and may regul…
View article: CD39 REGULATES P2RX7-MEDIATED LUNG NECROTIC LESIONS IN SEVERE EXPERIMENTAL TUBERCULOSIS
CD39 REGULATES P2RX7-MEDIATED LUNG NECROTIC LESIONS IN SEVERE EXPERIMENTAL TUBERCULOSIS Open
SUMMARY Tuberculosis induces diverse lesions, such as necrotic pneumonia, contributing to disease progression and transmission. Despite advances in understanding the role of ATP-gated P2RX7 ion channels in developing severe forms of tuberc…
View article: Sensing of extracellular ATP via P2RX7 drives lung tumor growth through regulatory T cell suppressive function
Sensing of extracellular ATP via P2RX7 drives lung tumor growth through regulatory T cell suppressive function Open
Lung cancer is the leading cause of cancer-related deaths worldwide and, despite treatment advances, immune suppression remains an obstacle to effective therapy. Effector CD4 + T cells (CD4 + Teffs) are critical for antitumor immunity, but…
View article: Increased macrophages contribute to thyroid hormone‐induced cardiac alterations in mice
Increased macrophages contribute to thyroid hormone‐induced cardiac alterations in mice Open
Aims The heart is one of the main targets of thyroid hormone. Patients with hyperthyroidism, a disease with high incidence in the population, have increased arrhythmia risk and cardiac hypertrophy, which is an independent predictor of adve…
View article: T cell-specific P2RX7 favors lung parenchymal CD4+ T cell accumulation in response to severe lung infections
T cell-specific P2RX7 favors lung parenchymal CD4+ T cell accumulation in response to severe lung infections Open
CD4+ T cells are key components of the immune response during lung infections and can mediate protection against tuberculosis (TB) or influenza. However, CD4+ T cells can also promote lung pathology during these infections, making it uncle…
View article: Oral exposure to <i>Escherichia coli</i> toxin protects against lung allergen-induced inflammation
Oral exposure to <i>Escherichia coli</i> toxin protects against lung allergen-induced inflammation Open
Recent studies suggest that the intestinal microenvironment regulate lung immune cells. Conversely, changes in the lung can modulate the gut immune system. Yet, mucosal-associated immune responses have been studied in a compartmentalized m…
View article: P2RX7 signaling drives the differentiation of Th1 cells through metabolic reprogramming for aerobic glycolysis
P2RX7 signaling drives the differentiation of Th1 cells through metabolic reprogramming for aerobic glycolysis Open
Introduction This study provides evidence of how Th1 cell metabolism is modulated by the purinergic receptor P2X7 (P2RX7), a cation cannel activated by high extracellular concentrations of adenosine triphosphate (ATP). Methods In vivo anal…
View article: P2RX7 signaling drives the differentiation of Th1 cells through metabolic reprogramming for aerobic glycolysis
P2RX7 signaling drives the differentiation of Th1 cells through metabolic reprogramming for aerobic glycolysis Open
This study provides evidence on the molecular mechanisms by which P2RX7 signaling promotes the differentiation of Th1 cells. In vivo analysis was performed in the Plasmodium chabaudi model of malaria in view of the great relevance of this …
View article: T cell-specific P2RX7 favors lung parenchymal CD4<sup>+</sup> T cell accumulation in response to severe lung infections
T cell-specific P2RX7 favors lung parenchymal CD4<sup>+</sup> T cell accumulation in response to severe lung infections Open
CD4 + T cells are key components of the immune response during lung infections and can mediate protection against tuberculosis (TB) or influenza. However, CD4 + T cells can also promote lung pathology during these infections, making it unc…
View article: LAMP-1 Chimeric to HIV-1 p55Gag in the Immunization of Neonate Mice Induces an Early Germinal Center Formation and AID Expression
LAMP-1 Chimeric to HIV-1 p55Gag in the Immunization of Neonate Mice Induces an Early Germinal Center Formation and AID Expression Open
Neonates have a limited adaptive response of plasma cells, germinal center (GC) B cells, and T follicular helper cells (TFH). As neonatal vaccination can be an important tool for AIDS prevention, these limitations need to be overcome. Chim…
View article: <scp>SARS‐CoV</scp> ‐2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytes
<span>SARS‐CoV</span> ‐2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytes Open
COVID‐19 causes more than million deaths worldwide. Although much is understood about the immunopathogenesis of the lung disease, a lot remains to be known on the neurological impact of COVID‐19. Here, we evaluated immunometabolic changes …
View article: Mycobacterium tuberculosis Induces Irg1 in Murine Macrophages by a Pathway Involving Both TLR-2 and STING/IFNAR Signaling and Requiring Bacterial Phagocytosis
Mycobacterium tuberculosis Induces Irg1 in Murine Macrophages by a Pathway Involving Both TLR-2 and STING/IFNAR Signaling and Requiring Bacterial Phagocytosis Open
Irg1 is an enzyme that generates itaconate, a metabolite that plays a key role in the regulation of inflammatory responses. Previous studies have implicated Irg1 as an important mediator in preventing excessive inflammation and tissue dama…
View article: Editorial: Extracellular Nucleotides in Lymphocyte Function
Editorial: Extracellular Nucleotides in Lymphocyte Function Open
EDITORIAL article Front. Cell Dev. Biol., 23 March 2022Sec. Signaling https://doi.org/10.3389/fcell.2022.892303
View article: Blockade of caspase cascade overcomes malaria-associated acute respiratory distress syndrome in mice
Blockade of caspase cascade overcomes malaria-associated acute respiratory distress syndrome in mice Open
Malaria is an enormous burden on global health that caused 409,000 deaths in 2019. Severe malaria can manifest in the lungs, an illness known as acute respiratory distress syndrome (ARDS). Not much is known about the development of malaria…
View article: SARS-CoV-2 Infection Impacts Carbon Metabolism and Depends on Glutamine for Replication in Syrian Hamster Astrocytes
SARS-CoV-2 Infection Impacts Carbon Metabolism and Depends on Glutamine for Replication in Syrian Hamster Astrocytes Open
Coronaviruses belong to a well-known family of enveloped RNA viruses and are the causative agent of the common cold. Although the seasonal coronaviruses do not pose a threat to human life, three members of this family, i.e., SARS-CoV, MERS…
View article: P2x7 Receptor Signaling Blockade Reduces Lung Inflammation and Necrosis During Severe Experimental Tuberculosis
P2x7 Receptor Signaling Blockade Reduces Lung Inflammation and Necrosis During Severe Experimental Tuberculosis Open
The risk of developing severe forms of tuberculosis has increased by the acquired immunodeficiency syndrome (AIDS) epidemic, lack of effective drugs to eliminate latent infection and the emergence of drug-resistant mycobacterial strains. E…
View article: Harmful Effects of Granulocytic Myeloid-Derived Suppressor Cells on Tuberculosis Caused by Hypervirulent Mycobacteria
Harmful Effects of Granulocytic Myeloid-Derived Suppressor Cells on Tuberculosis Caused by Hypervirulent Mycobacteria Open
Background The role of myeloid-derived suppressor cells (MDSCs) in patients with severe tuberculosis who suffer from uncontrolled pulmonary inflammation caused by hypervirulent mycobacterial infection remains unclear. Methods This issue wa…
View article: Combining Host Genetics and Functional Analysis to Depict Inflammasome Contribution in Tuberculosis Susceptibility and Outcome in Endemic Areas
Combining Host Genetics and Functional Analysis to Depict Inflammasome Contribution in Tuberculosis Susceptibility and Outcome in Endemic Areas Open
The interplay between M. tuberculosis (Mtb) and humans is multifactorial. The susceptibility/resistance profile and the establishment of clinical tuberculosis (TB) still remains elusive. The gain-of-function variant rs10754558 in the NLRP3…
View article: Correction: CD28 deficiency leads to accumulation of germinal-center independent IgM+ experienced B cells and to production of protective IgM during experimental malaria
Correction: CD28 deficiency leads to accumulation of germinal-center independent IgM+ experienced B cells and to production of protective IgM during experimental malaria Open
[This corrects the article DOI: 10.1371/journal.pone.0202522.].
View article: Inhibiting Adenosine Receptor Signaling Promotes Accumulation of Effector CD4+ T Cells in the Lung Parenchyma During Severe Tuberculosis
Inhibiting Adenosine Receptor Signaling Promotes Accumulation of Effector CD4+ T Cells in the Lung Parenchyma During Severe Tuberculosis Open
These results indicate that adenosine, which may be generated by extracellular adenosine triphosphate degradation, impairs the parenchymal CD4+ T-cell response and contributes to the development of severe tuberculosis.
CD28 deficiency leads to accumulation of germinal-center independent IgM+ experienced B cells and to production of protective IgM during experimental malaria Open
Protective immunity to blood-stage malaria is attributed to Plasmodium-specific IgG and effector-memory T helper 1 (Th1) cells. However, mice lacking the costimulatory receptor CD28 (CD28KO) maintain chronic parasitemia at low levels and d…
View article: MyD88 activation in cardiomyocytes contributes to the heart immune response to acute Trypanosoma cruzi infection with no effect on local parasite control
MyD88 activation in cardiomyocytes contributes to the heart immune response to acute Trypanosoma cruzi infection with no effect on local parasite control Open
Cardiomyopathy is the most serious consequence of Chagas disease, a neglected human disorder caused by Trypanosoma cruzi infection. Because T. cruzi parasites invade cardiomyocytes, we sought to investigate whether these cells recognize th…
View article: Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages
Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages Open
Lysosomal cathepsin B (CTSB) has been proposed to play a role in the induction of acute inflammation. We hypothesised that the presence of active CTSB in the cytosol is crucial for NLRP3-inflammasome assembly and, consequently, for mature …
View article: Programmed Cell Death Protein 1–PDL1 Interaction Prevents Heart Damage in Chronic Trypanosoma cruzi Infection
Programmed Cell Death Protein 1–PDL1 Interaction Prevents Heart Damage in Chronic Trypanosoma cruzi Infection Open
Chagas disease is a neglected parasitic infection that affects around six to seven million people, mainly in Latin America. About 30-35% of infected people present chronic Chagas cardiomyopathy (CCC), which eventually leads to death. This …
View article: Publisher Correction: TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria
Publisher Correction: TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria Open
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
View article: Correction: Targeting Neutrophils to Prevent Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome in Mice
Correction: Targeting Neutrophils to Prevent Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome in Mice Open
[This corrects the article DOI: 10.1371/journal.ppat.1006054.].