Imran Kazmi
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View article: Cubebin Attenuates Methamphetamine-Induced Neurotoxicity Through CREB/BDNF/Caspase-3 Signaling: In Vivo and In Silico Study
Cubebin Attenuates Methamphetamine-Induced Neurotoxicity Through CREB/BDNF/Caspase-3 Signaling: In Vivo and In Silico Study Open
Background and Objectives: Methamphetamine (METH) is a potent psychostimulant known to induce neurotoxicity and neurodegeneration, leading to cognitive impairment. This study aimed to explore cubebin’s potential neuroprotective effects aga…
View article: Enhancing knowledge of hypertension among general practitioners in Pakistan through a Train-The-Trainer initiative
Enhancing knowledge of hypertension among general practitioners in Pakistan through a Train-The-Trainer initiative Open
Background Hypertension (HTN) affects over a billion people worldwide, with most cases in low- and middle-income countries (LMICs) where awareness and control remain low. In Pakistan, general practitioners (GPs) are usually the initial con…
View article: Antimicrobial Peptides: Mechanisms, Applications, and Therapeutic Potential
Antimicrobial Peptides: Mechanisms, Applications, and Therapeutic Potential Open
Antimicrobial peptides (AMPs) are short protein fragments that function as an innate immune response across diverse life forms. Structurally, AMPs exhibit diverse configurations, including α-helical, β-sheet, mixed, and random-coil forms, …
View article: Effects of a Rosiridin against Rotenone-induced Rats Model of Parkinson's Disease: In-vivo Study and in silico Molecular Modeling
Effects of a Rosiridin against Rotenone-induced Rats Model of Parkinson's Disease: In-vivo Study and in silico Molecular Modeling Open
Aim: The investigation aimed to study the outcome of rosiridin in Parkinson's disease (PD) induced by rotenone (ROT) in rodents. Methods: Rodents were randomized into IV groups and were induced with ROT followed by treatment with rosiridin…
View article: Parthanatos and apoptosis: unraveling their roles in cancer cell death and therapy resistance
Parthanatos and apoptosis: unraveling their roles in cancer cell death and therapy resistance Open
Cell death is a fundamental process that needs to be maintained to balance cellular functions and prevent disease. There are several cell death pathways; however, apoptosis and parthanatos are the most prominent and have important roles in…
View article: In vivo and in silico study of europinidin against streptozotocin-isoproterenol-induced myocardial damage via alteration of hs-CRP/CPK-MB/Caspase-3/Bcl-2 pathways
In vivo and in silico study of europinidin against streptozotocin-isoproterenol-induced myocardial damage via alteration of hs-CRP/CPK-MB/Caspase-3/Bcl-2 pathways Open
View article: Rosiridin Protects Against Aluminum Chloride-Induced Memory Impairment via Modulation of BDNF/NFκB/PI3K/Akt Pathway in Rats
Rosiridin Protects Against Aluminum Chloride-Induced Memory Impairment via Modulation of BDNF/NFκB/PI3K/Akt Pathway in Rats Open
Background and Objectives: Rosiridin is a monoterpene with outstanding monoamine inhibitory activity that is useful to treat depressive episodes and rapid-onset dementia. The current investigation aims to evaluate the neurologically protec…
View article: 6-Shogaol Abrogates Parkinson’s Disease in Rotenone-Induced Rodents: Based on In Silico Study and Inhibiting TNF-α/NF-κB/IL-1β/MAO-B
6-Shogaol Abrogates Parkinson’s Disease in Rotenone-Induced Rodents: Based on In Silico Study and Inhibiting TNF-α/NF-κB/IL-1β/MAO-B Open
Background/Objectives: 6-Shogaol is a comparatively innovative anti-Parkinson’s remedy with antioxidant and anti-inflammatory characteristics. This investigation intended to determine the role of 6-shogaol in the Parkinson’s disease (PD) p…
View article: Therapeutic approaches targeting aging and cellular senescence in Huntington's disease
Therapeutic approaches targeting aging and cellular senescence in Huntington's disease Open
Huntington's disease (HD) is a devastating neurodegenerative disease that is manifested by a gradual loss of physical, cognitive, and mental abilities. As the disease advances, age has a major impact on the pathogenic signature of mutant h…
View article: Protective activity of hirsutidin in high-fat intake and streptozotocin-induced diabetic rats: In silico and in vivo study
Protective activity of hirsutidin in high-fat intake and streptozotocin-induced diabetic rats: In silico and in vivo study Open
View article: lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer
lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer Open
Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies have demonstrated that copper accumulation induces a unique form of cell deat…
View article: In vivo and computational investigation of butin against alloxan-induced diabetes via biochemical, histopathological, and molecular interactions
In vivo and computational investigation of butin against alloxan-induced diabetes via biochemical, histopathological, and molecular interactions Open
Herbs have been used as medicines since antiquity, and it has been discovered that the human body responds well to herbal remedies. Research on the effect of butin was conducted in the current study in the alloxan-induced diabetic rat para…
View article: 6-shogaol against 3-Nitropropionic acid-induced Huntington’s disease in rodents: Based on molecular docking/targeting pro-inflammatory cytokines/NF-κB-BDNF-Nrf2 pathway
6-shogaol against 3-Nitropropionic acid-induced Huntington’s disease in rodents: Based on molecular docking/targeting pro-inflammatory cytokines/NF-κB-BDNF-Nrf2 pathway Open
Background Huntington’s disease (HD) is an extremely harmful autosomal inherited neurodegenerative disease. Motor dysfunction, mental disorder, and cognitive deficits are the characteristic features of this disease. The current study exami…
View article: Barbaloin Protects Pentylenetetrazol-Induced Cognitive Deficits in Rodents via Modulation of Neurotransmitters and Inhibition of Oxidative-Free-Radicals-Led Inflammation
Barbaloin Protects Pentylenetetrazol-Induced Cognitive Deficits in Rodents via Modulation of Neurotransmitters and Inhibition of Oxidative-Free-Radicals-Led Inflammation Open
Background: Epilepsy is defined by an excessive level of activity in the neurons and coordinated bursts of electrical activity, resulting in the occurrence of seizure episodes. The precise cause of epileptogenesis remains uncertain; nevert…
View article: Deciphering NF-κB pathways in smoking-related lung carcinogenesis
Deciphering NF-κB pathways in smoking-related lung carcinogenesis Open
One of the main causes of death worldwide is lung cancer, which is largely caused by cigarette smoking. The crucial transcription factor NF-κB, which controls inflammatory responses and various cellular processes, is a constitutively prese…
View article: Autophagy‐associated non‐coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis
Autophagy‐associated non‐coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis Open
Background Parkinson's disease (PD) is a degenerative neurological condition marked by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta. The precise etiology of PD remains unclear, but emerging evidence sugges…
View article: Non-coding RNA mediated regulation of PI3K/Akt pathway in hepatocellular carcinoma: Therapeutic perspectives
Non-coding RNA mediated regulation of PI3K/Akt pathway in hepatocellular carcinoma: Therapeutic perspectives Open
Hepatocellular carcinoma (HCC) is among the primary reasons for fatalities caused by cancer globally, highlighting the need for comprehensive knowledge of its molecular aetiology to develop successful treatment approaches. The PI3K/Akt sys…
View article: Oxidative Coupling and Self-Assembly of Polyphenols for the Development of Novel Biomaterials
Oxidative Coupling and Self-Assembly of Polyphenols for the Development of Novel Biomaterials Open
In recent years, the development of biomaterials from green organic sources with nontoxicity and hyposensitivity has been explored for a wide array of biotherapeutic applications. Polyphenolic compounds have unique structural features, and…
View article: The impact of formaldehyde exposure on lung inflammatory disorders: Insights into asthma, bronchitis, and pulmonary fibrosis
The impact of formaldehyde exposure on lung inflammatory disorders: Insights into asthma, bronchitis, and pulmonary fibrosis Open
Lung inflammatory disorders are a major global health burden, impacting millions of people and raising rates of morbidity and death across many demographic groups. An industrial chemical and common environmental contaminant, formaldehyde (…
View article: Enhancing Hypertension Diagnosis and Management Knowledge among General Practitioners in Pakistan: Evaluating the Impact of the Train the Trainer (TTT) Initiative.
Enhancing Hypertension Diagnosis and Management Knowledge among General Practitioners in Pakistan: Evaluating the Impact of the Train the Trainer (TTT) Initiative. Open
Background: In Pakistan hypertension often coexists with illnesses such, as diabetes mellitus, cardiovascular disease and chronic kidney disease. This underscores the need for updated research to accurately represent how hypertension is di…
View article: Kaempferol: Paving the path for advanced treatments in aging-related diseases
Kaempferol: Paving the path for advanced treatments in aging-related diseases Open
Aging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently needed. Kaempferol, a flavonoid found in several plants, has emerged as a promising candidate for ameliorating ARDs. Th…
View article: Hibiscetin attenuates lipopolysaccharide-evoked memory impairment by inhibiting BDNF/caspase-3/NF-κB pathway in rodents
Hibiscetin attenuates lipopolysaccharide-evoked memory impairment by inhibiting BDNF/caspase-3/NF-κB pathway in rodents Open
This study explores the neuroprotective potential of hibiscetin concerning memory deficits induced by lipopolysaccharide (LPS) injection in rats. The aim of this study is to evaluate the effect of hibiscetin against LPS-injected memory def…
View article: Barbaloin’s Chemical Intervention in Aluminum Chloride Induced Cognitive Deficits and Changes in Rats through Modulation of Oxidative Stress, Cytokines, and BDNF Expression
Barbaloin’s Chemical Intervention in Aluminum Chloride Induced Cognitive Deficits and Changes in Rats through Modulation of Oxidative Stress, Cytokines, and BDNF Expression Open
Alzheimer's disease (AD) is a long-term neurodegenerative condition characterized by impaired cognitive functions, particularly in the domains of learning and memory. Finding promising options for AD can be successful with a medication rep…
View article: Erucic acid treatment in lipopolysaccharide-induced anxiety and depression using ADMET properties / behaviour paradigms / interleukins pathways in rats
Erucic acid treatment in lipopolysaccharide-induced anxiety and depression using ADMET properties / behaviour paradigms / interleukins pathways in rats Open
The neuroimmune system plays a vital role in the etiology of anxiety and depression. In the current research, the aim was to investigate erucic acid's ability to counteract depression and anxiety induced by lipopolysaccharide (LPS) in rats…
View article: Ferroptosis and circular RNAs: new horizons in cancer therapy
Ferroptosis and circular RNAs: new horizons in cancer therapy Open
Cancer poses intricate challenges to treatment due to its complexity and diversity. Ferroptosis and circular RNAs (circRNAs) are emerging as innovative therapeutic avenues amid the evolving landscape of cancer therapy. Extensive investigat…
View article: Protective effect of sterubin against neurochemical and behavioral impairments in rotenone-induced Parkinson's disease
Protective effect of sterubin against neurochemical and behavioral impairments in rotenone-induced Parkinson's disease Open
This study was conducted to evaluate how sterubin affects rotenone-induced Parkinson's disease (PD) in rats. A total of 24 rats were distributed into 4 equal groups: normal saline control and rotenone control were administered saline or ro…
View article: Oxyphenbutazone ameliorates carfilzomib induced cardiotoxicity in rats via inhibition of oxidative free radical burst and NF-κB/IκB-α pathway
Oxyphenbutazone ameliorates carfilzomib induced cardiotoxicity in rats via inhibition of oxidative free radical burst and NF-κB/IκB-α pathway Open
Carfilzomib (CFZ), a chemotherapeutic agent used for multiple myeloma treatments reported to cause high incidence of cardiac events either new onset and/or exacerbate formerly diagnosed heart failure with ventricular and myocardial dysfunc…
View article: Butin prevent liver damage triggered by D-galactosamine via regulating lipid peroxidation and proinflammatory cytokines in rodents
Butin prevent liver damage triggered by D-galactosamine via regulating lipid peroxidation and proinflammatory cytokines in rodents Open
Objectives: Liver damage is becoming a more severe problem around the world. Unfortunately, there is still a great need for clinically effective pharmacological therapy for liver injury. The investigation aimed to assess the favorable outc…
View article: New Horizons in Lung Cancer Management Through ATR/CHK1 Pathway Modulation
New Horizons in Lung Cancer Management Through ATR/CHK1 Pathway Modulation Open
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View article: Unraveling NEAT1's complex role in lung cancer biology: a comprehensive review
Unraveling NEAT1's complex role in lung cancer biology: a comprehensive review Open
This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin re…