Imran Rizvi
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View article: Photodynamic priming ( <scp>PDP</scp> ) targets platinum resistance from chronic perfluoroalkyl substances ( <scp>PFAS</scp> ) exposure in ovarian cancer cells
Photodynamic priming ( <span>PDP</span> ) targets platinum resistance from chronic perfluoroalkyl substances ( <span>PFAS</span> ) exposure in ovarian cancer cells Open
Photodynamic therapy (PDT) is a photochemistry‐based treatment modality that synergizes with traditional agents and can overcome chemoresistance. Eighty percent of ovarian cancer patients develop chemoresistant disease, highlighting the ne…
View article: Chronic PFAS exposure induces chemotherapy resistance by promoting mitochondria-related alterations in ovarian cancer cells
Chronic PFAS exposure induces chemotherapy resistance by promoting mitochondria-related alterations in ovarian cancer cells Open
Resistance to chemotherapy is a major barrier to the effective treatment of ovarian cancer; however, the role of environmental exposures in the onset of chemoresistance remains elusive. Our previous work in ovarian cancer cells suggests th…
View article: Mitochondrial membrane hyperpolarization modulates nuclear DNA methylation and gene expression through phospholipid remodeling
Mitochondrial membrane hyperpolarization modulates nuclear DNA methylation and gene expression through phospholipid remodeling Open
View article: Photodynamic priming overcomes platinum resistance from short‐term exposure to select perfluoroalkyl substances in endometrial cancer cell lines
Photodynamic priming overcomes platinum resistance from short‐term exposure to select perfluoroalkyl substances in endometrial cancer cell lines Open
First‐line treatment for advanced‐stage or recurrent endometrial cancer consists of platinum‐ and taxane‐based chemotherapy, to which many patients will develop resistance. Determining the factors that contribute to platinum resistance and…
View article: Prognostic Model to Predict Outcome of Adult Patients with Tuberculous Meningitis Undergoing Ventriculoperitoneal Shunt Surgery: A Prospective Observational Study
Prognostic Model to Predict Outcome of Adult Patients with Tuberculous Meningitis Undergoing Ventriculoperitoneal Shunt Surgery: A Prospective Observational Study Open
About 39% of adult patients with tuberculous meningitis die or remain disabled after VP shunt surgery. Medical Research Council grade III illness, papilledema, seizures, and size of hydrocephalus are the most important baseline predictors …
View article: Fractionated photoimmunotherapy stimulates an anti-tumour immune response: an integrated mathematical and in vitro study
Fractionated photoimmunotherapy stimulates an anti-tumour immune response: an integrated mathematical and in vitro study Open
View article: <scp>PpIX</scp>‐enabled fluorescence‐based detection and photodynamic priming of platinum‐resistant ovarian cancer cells under fluid shear stress
<span>PpIX</span>‐enabled fluorescence‐based detection and photodynamic priming of platinum‐resistant ovarian cancer cells under fluid shear stress Open
Over 75% percent of ovarian cancer patients are diagnosed with advanced‐stage disease characterized by unresectable intraperitoneal dissemination and the presence of ascites, or excessive fluid build‐up within the abdomen. Conventional tre…
View article: Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance
Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance Open
Resistance to platinum‐based chemotherapies remains a significant challenge in advanced‐stage high‐grade serous ovarian carcinoma, and patients with malignant ascites face the poorest outcomes. It is, therefore, important to understand the…
View article: Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance
Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance Open
Resistance to platinum-based chemotherapies remains a significant challenge in advanced-stage high-grade serous ovarian carcinoma, and patients with malignant ascites face the poorest outcomes. It is, therefore, important to understand the…
View article: Comparison of Photodynamic Priming Efficacy, with BPD or ALA-PpIX, to Overcome PFAS-Induced Platinum Resistance in Ovarian Cancer
Comparison of Photodynamic Priming Efficacy, with BPD or ALA-PpIX, to Overcome PFAS-Induced Platinum Resistance in Ovarian Cancer Open
Ovarian cancer is the most lethal gynecologic cancer, largely due to the development of platinum-based chemotherapy resistance. Understanding sources of chemoresistance and the development of mechanism-based treatments are critical. In a r…
View article: Exposure to select PFAS and PFAS mixtures alters response to platinum-based chemotherapy in endometrial cancer cell lines
Exposure to select PFAS and PFAS mixtures alters response to platinum-based chemotherapy in endometrial cancer cell lines Open
Background Exposure to per- and poly-fluoroalkyl substances (PFAS) has been associated with significant alterations in female reproductive health. These include changes in menstrual cyclicity, timing of menarche and menopause, and fertilit…
View article: Transient fluid flow improves photoimmunoconjugate delivery and photoimmunotherapy efficacy
Transient fluid flow improves photoimmunoconjugate delivery and photoimmunotherapy efficacy Open
Circulating drugs in the peritoneal cavity is an effective strategy for advanced ovarian cancer treatment. Photoimmunotherapy, an emerging modality with potential for the treatment of ovarian cancer, involves near-infrared light activation…
View article: Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer
Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer Open
Mitochondria are regulators of key cellular processes, including energy production and redox homeostasis. Mitochondrial dysfunction is associated with various human diseases, including cancer. Importantly, both structural and functional ch…
View article: Figure S1 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis
Figure S1 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis Open
Platinum-resistant human epithelial ovarian cancer cell lines OVCAR-5 and OVCAR-4 expresses tyrosyl-DNA phosphodiesterase 1 (Tdp1). The Tdp1 protein expression levels in human epithelial ovarian carcinoma cell lines OVCAR-5 (derived from t…
View article: Table S1 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis
Table S1 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis Open
Physical characterizations of nanoliposomal irinotecan (nal-IRI) for in vivo study.
View article: Supplementary Methods and Figures 1-8 from Vitamin D Receptor Activation and Photodynamic Priming Enables Durable Low-dose Chemotherapy
Supplementary Methods and Figures 1-8 from Vitamin D Receptor Activation and Photodynamic Priming Enables Durable Low-dose Chemotherapy Open
Supplementary Methods Supplemental Figure 1: The MIA-PaCa-2 + PCAF model exhibits histologic features consistent with desmoplasia 90 days post implantation Supplemental Figure 2: 1 μM calcipitriol activates the vitamin D receptor (VDR) in …
View article: Supplementary Methods and Figures 1-8 from Vitamin D Receptor Activation and Photodynamic Priming Enables Durable Low-dose Chemotherapy
Supplementary Methods and Figures 1-8 from Vitamin D Receptor Activation and Photodynamic Priming Enables Durable Low-dose Chemotherapy Open
Supplementary Methods Supplemental Figure 1: The MIA-PaCa-2 + PCAF model exhibits histologic features consistent with desmoplasia 90 days post implantation Supplemental Figure 2: 1 μM calcipitriol activates the vitamin D receptor (VDR) in …
View article: Figure S1 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis
Figure S1 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis Open
Platinum-resistant human epithelial ovarian cancer cell lines OVCAR-5 and OVCAR-4 expresses tyrosyl-DNA phosphodiesterase 1 (Tdp1). The Tdp1 protein expression levels in human epithelial ovarian carcinoma cell lines OVCAR-5 (derived from t…
View article: Figure S2 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis
Figure S2 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis Open
Representative size distribution of nanoliposomal irinotecan (nal-IRI) and absorbance spectrum of nal-IRI in DMSO. (A) Mono-dispersed nal-IRI is approximately 115 nm in diameter with a Polydispersity index below 0.1. (B) Nal-IRI absorbance…
View article: Table S2 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis
Table S2 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis Open
Comparison of minocycline and irinotecan doses used in this study versus in the clinic.
View article: Table S4 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis
Table S4 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis Open
Preliminary analysis of costs related to the side effect management for irinotecan-based combination therapies.
View article: Data from Vitamin D Receptor Activation and Photodynamic Priming Enables Durable Low-dose Chemotherapy
Data from Vitamin D Receptor Activation and Photodynamic Priming Enables Durable Low-dose Chemotherapy Open
Patients with cancer often confront the decision of whether to continue high-dose chemotherapy at the expense of cumulative toxicities. Reducing the dose of chemotherapy regimens while preserving efficacy is sorely needed to preserve the p…
View article: Table S4 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis
Table S4 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis Open
Preliminary analysis of costs related to the side effect management for irinotecan-based combination therapies.
View article: Table S2 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis
Table S2 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis Open
Comparison of minocycline and irinotecan doses used in this study versus in the clinic.
View article: Table S3 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis
Table S3 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis Open
Preliminary analysis of combining minocycline and irinotecan regimen indicates significant cost savings compared to other irinotecan-based combination therapies.
View article: Data from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis
Data from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis Open
Mechanism-inspired drug repurposing that augments standard treatments offers a cost-effective and rapid route toward addressing the burgeoning problem of plateauing of effective therapeutics for drug-resistant micrometastases. We show that…
View article: Data from Vitamin D Receptor Activation and Photodynamic Priming Enables Durable Low-dose Chemotherapy
Data from Vitamin D Receptor Activation and Photodynamic Priming Enables Durable Low-dose Chemotherapy Open
Patients with cancer often confront the decision of whether to continue high-dose chemotherapy at the expense of cumulative toxicities. Reducing the dose of chemotherapy regimens while preserving efficacy is sorely needed to preserve the p…
View article: Table S1 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis
Table S1 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis Open
Physical characterizations of nanoliposomal irinotecan (nal-IRI) for in vivo study.
View article: Figure S3 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis
Figure S3 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis Open
The combination of minocycline and nanoliposomal irinotecan (nal-IRI) is tolerable by mice bearing human OVCAR-4 cells. Changes in mouse body weight were monitored longitudinally before and after treatment. The following treatments were gi…
View article: Table S3 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis
Table S3 from Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis Open
Preliminary analysis of combining minocycline and irinotecan regimen indicates significant cost savings compared to other irinotecan-based combination therapies.