Imran Zafar
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View article: Role of green-synthesized and characterization of calcium oxide nanoparticles for sustainable wheat growth in saline environments
Role of green-synthesized and characterization of calcium oxide nanoparticles for sustainable wheat growth in saline environments Open
Salinity is a major abiotic stress limiting wheat (Triticum aestivum L.) productivity. This study investigated the efficacy of green-synthesized calcium oxide nanoparticles (CaONPs) from Nigella sativa seeds in enhancing wheat growth under…
View article: Rapid and sensitive detection of bovine Theileria annulata parasite based on ERA-CRISPR/Cas12a technology
Rapid and sensitive detection of bovine Theileria annulata parasite based on ERA-CRISPR/Cas12a technology Open
Theileria annulata , a globally significant blood parasite in livestock, causes substantial economic losses in resource-limited regions by compromising animal health and hindering the development of the livestock industry. To address this,…
View article: Proximate Analysis and Multifunctional Roles of C. cyminum (Zeera) Extract for Investigating the Frontier of Hypolipidemic and Anti-Obesity Efficacy in Women
Proximate Analysis and Multifunctional Roles of C. cyminum (Zeera) Extract for Investigating the Frontier of Hypolipidemic and Anti-Obesity Efficacy in Women Open
This study examines the impact of C. cyminum (Zeera) powder intervention on various health parameters, including proximate analysis, lipid profile assessment, and anthropometric measurements. Proximate analysis revealed moisture (7.56±0.55…
View article: <b>NANOPARTICLE-BASED TARGETED DRUG DELIVERY FOR THE TREATMENT OF HEMATOLOGICAL DISORDERS</b>
<b>NANOPARTICLE-BASED TARGETED DRUG DELIVERY FOR THE TREATMENT OF HEMATOLOGICAL DISORDERS</b> Open
Nanoparticles have emerged as a highly advanced and promising drug delivery system (DDS) for the treatment of hematological disorders, including anemia, leukemia, and hemophilia. Traditional therapeutic approaches often involve systemic dr…
View article: Deep learning-based computational approach for predicting ncRNAs-disease associations in metaplastic breast cancer diagnosis
Deep learning-based computational approach for predicting ncRNAs-disease associations in metaplastic breast cancer diagnosis Open
Non-coding RNAs (ncRNAs) play a crucial role in breast cancer progression, necessitating advanced computational approaches for precise disease classification. This study introduces a Deep Reinforcement Learning (DRL)-based framework for pr…
View article: Early detection and analysis of accurate breast cancer for improved diagnosis using deep supervised learning for enhanced patient outcomes
Early detection and analysis of accurate breast cancer for improved diagnosis using deep supervised learning for enhanced patient outcomes Open
Early detection of breast cancer (BC) is essential for effective treatment and improved prognosis. This study compares the performance of various machine learning (ML) algorithms, including convolutional neural networks (CNNs), logistic re…
View article: Author Correction: Analysis of Machine Learning Algorithms for Real-Time Gallbladder Stone Identification from Ultrasound Images in Clinical Decision Support Systems
Author Correction: Analysis of Machine Learning Algorithms for Real-Time Gallbladder Stone Identification from Ultrasound Images in Clinical Decision Support Systems Open
View article: Analysis of Machine Learning Algorithms for Real-Time Gallbladder Stone Identification from Ultrasound Images in Clinical Decision Support Systems
Analysis of Machine Learning Algorithms for Real-Time Gallbladder Stone Identification from Ultrasound Images in Clinical Decision Support Systems Open
Global epidemiology of gallstones in the twenty-first century affects millions of individuals, and ultrasound diagnostics effectively assess gallbladder size and function and detect abnormalities. This study collected datasets from local h…
View article: Frequency of Vaginal Birth after C-Section and Factors Associated with Successful Trial of Vaginal Birth after C-Section
Frequency of Vaginal Birth after C-Section and Factors Associated with Successful Trial of Vaginal Birth after C-Section Open
A repeat cesarean section is often a more favorable and comfortable option for women who have previously undergone a cesarean section. Objective: To determine the prevalence and the maternal and obstetric factors influencing the likelihood…
View article: Characterization of Potential Virus Resistance Genes in Different Crops Through In-silico Approaches
Characterization of Potential Virus Resistance Genes in Different Crops Through In-silico Approaches Open
Begomoviruses, particularly the cotton leaf curl virus (CLCuV), pose significant threats to global agriculture, especially cotton production. This study identified five resistance gene analogs (RGAs)—KT250635, KT886994, KT633945, KT885194,…
View article: In-Silico Analysis of Genetic Mutations in BRAF and PMS2 for Biomarker Discovery to Transform Colorectal Cancer Research
In-Silico Analysis of Genetic Mutations in BRAF and PMS2 for Biomarker Discovery to Transform Colorectal Cancer Research Open
Point mutations in the PMS2 and BRAF genes have emerged as critical drivers of colorectal cancer, influencing key cellular processes such as mismatch repair and signal transduction. Understanding the impact of these mutations at the molecu…
View article: Exploration of plant alkaloids as potential inhibitors of <i>HIV</i>–CD4 binding: Insight into comprehensive <i>in silico</i> approaches
Exploration of plant alkaloids as potential inhibitors of <i>HIV</i>–CD4 binding: Insight into comprehensive <i>in silico</i> approaches Open
This study investigates the potential of alkaloids – nitidine, harmine, harmaline, berberine, and magnoflurine – as inhibitors of HIV –CD4 binding, focusing on their molecular interactions, binding affinities, and pharmacokinetic propertie…
View article: Preassembled complexes of hAgo2 and ssRNA delivered by nanoparticles: a novel silencing gene expression approach overcoming the absence of the canonical pathway of siRNA processing in the apicomplexan parasite Babesia microti, blood parasite of veterinary and zoonotic importance
Preassembled complexes of hAgo2 and ssRNA delivered by nanoparticles: a novel silencing gene expression approach overcoming the absence of the canonical pathway of siRNA processing in the apicomplexan parasite Babesia microti, blood parasite of veterinary and zoonotic importance Open
Due to the lack of efficacy of the currently used chemical drugs, poor tick control, and lack of effective vaccines against Babesia, novel control strategies are urgently needed. In this regard, searching for anti-Babesia gen…
View article: Frequency of Covert Urinary Retention in Women after Vaginal Birth of Baby
Frequency of Covert Urinary Retention in Women after Vaginal Birth of Baby Open
Postpartum Covert Urinary Retention (PPUR) is a medical condition in which a woman’s spontaneous ability to micturate is present and the patient passes urine but the problem lies with the residual volume of urine as it was higher than norm…
View article: The detection of zoonotic microorganisms in Rhipicephalus sanguineus (brown dog ticks) from Vietnam and the frequency of tick infestations in owned dogs
The detection of zoonotic microorganisms in Rhipicephalus sanguineus (brown dog ticks) from Vietnam and the frequency of tick infestations in owned dogs Open
Dog owners are greatly concerned about tick infestations in their pets. The prevalence and dispersion of ticks and their disease-causing microorganisms have been limited from the viewpoint of dog owners in Vietnam. This study investigated …
View article: In silico and in vitro study of bioactive compounds from Allium sativum with PTEN: A novel target and promising source for cancer diagnostic potentials
In silico and in vitro study of bioactive compounds from Allium sativum with PTEN: A novel target and promising source for cancer diagnostic potentials Open
Introduction: Cancer remains a significant global health issue, necessitating innovative management strategies. The tumor suppressor protein PTEN, due to its pivotal role in cancer development, is a promising target for therapeutic interve…
View article: Nutrients, surfactants, and aeration in constructed wetlands affect bacterial persistence and metabolic activity during the remediation of crude oil-contaminated water
Nutrients, surfactants, and aeration in constructed wetlands affect bacterial persistence and metabolic activity during the remediation of crude oil-contaminated water Open
The use of constructed wetlands (CWs) is one of the best options to treat wastewater. In CWs, microorganisms play a major role in the degradation of organic pollutants but the concentration of nutrients, surfactant, and aeration (NSA) in o…
View article: Multifunctional Analysis of Banana Leaves Extracts for Dyeing Properties of Pima Cotton Fabric Using Different Mordants
Multifunctional Analysis of Banana Leaves Extracts for Dyeing Properties of Pima Cotton Fabric Using Different Mordants Open
Introduction Natural dyes have become very important for decades based on their extensive properties compared to synthetic dyes. Pima cotton was dyed with natural dyes derived from plants using mordants, a crucial step in modern industry. …
View article: Epidemiological Investigation of Tick-Borne Bacterial Pathogens in Domestic Animals from the Qinghai–Tibetan Plateau Area, China
Epidemiological Investigation of Tick-Borne Bacterial Pathogens in Domestic Animals from the Qinghai–Tibetan Plateau Area, China Open
The Qinghai–Tibetan Plateau area (QTPA) features a unique environment that has witnessed the selective breeding of diverse breeds of domestic livestock exhibiting remarkable adaptability. Nevertheless, Anaplasma spp., Rickettsia spp., Coxi…
View article: A Survey of Tick Infesting Owned Dogs and Zoonotic Microorganism Detection in Rhipicephalus Sanguineus (Brown Dog Tick) from Vietnam
A Survey of Tick Infesting Owned Dogs and Zoonotic Microorganism Detection in Rhipicephalus Sanguineus (Brown Dog Tick) from Vietnam Open
View article: Epidemiological Investigation of Tick-Borne Bacterial Pathogens in Domestic Animals from the Qinghai-Tibetan Plateau Area, China
Epidemiological Investigation of Tick-Borne Bacterial Pathogens in Domestic Animals from the Qinghai-Tibetan Plateau Area, China Open
The Qinghai-Tibetan Plateau area (QTPA) features a unique environment that has witnessed the selective breeding of diverse breeds of domestic livestock, exhibiting remarkable adaptability. Nevertheless, Anaplasma spp., Rickettsia spp., Cox…
View article: Climate-Resilient Forest Economics: Adapting Tree Species Rotation for Changing Times
Climate-Resilient Forest Economics: Adapting Tree Species Rotation for Changing Times Open
The economic implications of rotation periods in tree plantation ventures are often underestimated. This study aims to determine the most financially rewarding rotation cycles for three tree species—Vachellia nilotica, Populus deltoides, a…
View article: In silico designing of multiepitope-based-peptide (MBP) vaccine against MAPK protein express for Alzheimer's disease in Zebrafish
In silico designing of multiepitope-based-peptide (MBP) vaccine against MAPK protein express for Alzheimer's disease in Zebrafish Open
View article: In silico and in vitro study of bioactive compounds of Nigella sativa for targeting neuropilins in breast cancer
In silico and in vitro study of bioactive compounds of Nigella sativa for targeting neuropilins in breast cancer Open
Introduction: Breast cancer poses a significant global challenge, prompting researchers to explore novel approaches for potential treatments. Material and Methods: For in vitro study we used thin layer chromatography (TAC) for phytochemica…
View article: Molecular Identification of Piroplasmids in Ticks from Infested Small Ruminants in Konya Province, Turkey
Molecular Identification of Piroplasmids in Ticks from Infested Small Ruminants in Konya Province, Turkey Open
Ticks play a pivotal role in propagating a diverse spectrum of infectious agents that detrimentally affect the health of both humans and animals. In the present study, a molecular survey was executed of piroplasmids in ticks collected from…
View article: Babesia microti alleviates disease manifestations caused by Plasmodium berghei ANKA in murine co-infection model of complicated malaria
Babesia microti alleviates disease manifestations caused by Plasmodium berghei ANKA in murine co-infection model of complicated malaria Open
Malaria remains one of the most significant health issues worldwide, accounting for 2.6% of the total global disease burden, and efforts to eliminate this threat continue. The key focus is to develop an efficient and long-term immunity to …
View article: Reviewing methods of deep learning for diagnosing COVID-19, its variants and synergistic medicine combinations
Reviewing methods of deep learning for diagnosing COVID-19, its variants and synergistic medicine combinations Open
View article: Elucidation of novel compounds and epitope-based peptide vaccine design against C30 endopeptidase regions of SARS-CoV-2 using immunoinformatics approaches
Elucidation of novel compounds and epitope-based peptide vaccine design against C30 endopeptidase regions of SARS-CoV-2 using immunoinformatics approaches Open
There has been progressive improvement in immunoinformatics approaches for epitope-based peptide design. Computational-based immune-informatics approaches were applied to identify the epitopes of SARS-CoV-2 to develop vaccines. The accessi…
View article: Amomum subulatum: A treasure trove of anti-cancer compounds targeting TP53 protein using in vitro and in silico techniques
Amomum subulatum: A treasure trove of anti-cancer compounds targeting TP53 protein using in vitro and in silico techniques Open
Cancer is a primary global health concern, and researchers seek innovative approaches to combat the disease. Clinical bioinformatics and high-throughput proteomics technologies provide powerful tools to explore cancer biology. Medicinal pl…
View article: Predicting the effects of rare genetic variants on oncogenic signaling pathways: A computational analysis of HRAS protein function
Predicting the effects of rare genetic variants on oncogenic signaling pathways: A computational analysis of HRAS protein function Open
The HRAS gene plays a crucial role in regulating essential cellular processes for life, and this gene's misregulation is linked to the development of various types of cancers. Nonsynonymous single nucleotide polymorphisms (nsSNPs) within t…