Imroze Khan
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View article: Diet Impacts the Effects of Thermal Stress on Infection Outcomes
Diet Impacts the Effects of Thermal Stress on Infection Outcomes Open
Background Climate change can lead to warmer environments, facilitating higher pathogen growth and increasing disease burden. Climate change can also reduce the nutritional value of food resources, causing malnutrition, which can lead to i…
View article: DIET IMPACTS THE EFFECTS OF THERMAL STRESS ON INFECTION OUTCOMES
DIET IMPACTS THE EFFECTS OF THERMAL STRESS ON INFECTION OUTCOMES Open
Background Climate change can lead to warmer environments, facilitating higher pathogen growth and increasing disease burden. Climate change can also reduce the nutritional value of food resources, causing malnutrition, which can lead to i…
View article: ADAPTATION AGAINST LONG-TERM PROTEIN DEPRIVATION TRADES OFF WITH IMMUNOCOMPETENCE AND THE ABILITY TO SURVIVE PATHOGENIC INFECTIONS
ADAPTATION AGAINST LONG-TERM PROTEIN DEPRIVATION TRADES OFF WITH IMMUNOCOMPETENCE AND THE ABILITY TO SURVIVE PATHOGENIC INFECTIONS Open
Insufficient protein intake, leading to malnutrition, is a major global health concern that compromises the immune system and increases susceptibility to diseases. In scenarios where protein availability is constrained, organisms may exper…
View article: Evolutionary Immunology
Evolutionary Immunology Open
Immune systems pose fascinating puzzles for evolutionary biologists. They feature some of the most polymorphic genes and reflect the strongest natural selection known. Evolution of immune systems plays a key role in host–parasite interacti…
View article: Pathogen growth and virulence dynamics drive the host evolution against coinfections
Pathogen growth and virulence dynamics drive the host evolution against coinfections Open
The occurrence of coinfections, where hosts are simultaneously infected by multiple pathogens, is widespread in nature and has significant negative impacts on global health. In humans, over one-sixth of the world’s population is affected b…
View article: Genome assembly and annotation of the red flour beetle (<i>Tribolium castaneum)</i>from India
Genome assembly and annotation of the red flour beetle (<i>Tribolium castaneum)</i>from India Open
The largest insect order, Coleoptera, includes several economically important beetles that also serve as major model species for biological research. Perhaps foremost among these is the red flour beetle, a global pest of stored grains and …
View article: PATHOGEN GROWTH AND VIRULENCE DYNAMICS DRIVE THE HOST EVOLUTION AGAINST COINFECTIONS
PATHOGEN GROWTH AND VIRULENCE DYNAMICS DRIVE THE HOST EVOLUTION AGAINST COINFECTIONS Open
Coinfections, or the simultaneous infection of hosts by multiple pathogens, are widespread in nature with significant negative impacts on global health. Can hosts evolve against such coinfections as effectively as they would against indivi…
View article: Disruption of flour beetle microbiota limits experimentally evolved immune priming response, but not pathogen resistance
Disruption of flour beetle microbiota limits experimentally evolved immune priming response, but not pathogen resistance Open
Host-associated microbiota play a fundamental role in the training and induction of different forms of immunity, including inducible as well as constitutive components. However, direct experiments analysing the relative importance of micro…
View article: Ageing leads to nonspecific antimicrobial peptide responses in <i>Drosophila melanogaster</i>
Ageing leads to nonspecific antimicrobial peptide responses in <i>Drosophila melanogaster</i> Open
Evolutionary theory predicts a late-life decline in the force of natural selection, possibly leading to late-life deregulations of the immune system. A potential outcome of such immune-deregulation is the inability to produce specific immu…
View article: The Animal Origin of Major Human Infectious Diseases: What Can Past Epidemics Teach Us About Preventing the Next Pandemic?
The Animal Origin of Major Human Infectious Diseases: What Can Past Epidemics Teach Us About Preventing the Next Pandemic? Open
Emerging infectious diseases are one of the greatest public health challenges. Approximately three-quarters of these diseases are of animal origin. These diseases include classical zoonoses maintained in humans only via transmission from o…
View article: Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm
Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm Open
Researchers worldwide are repeatedly warning us against future zoonotic diseases resulting from humankind’s insurgence into natural ecosystems. The same zoonotic pathogens that cause severe infections in a human host frequently fail to pro…
View article: Why do insects evolve immune priming? A search for crossroads
Why do insects evolve immune priming? A search for crossroads Open
View article: Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity
Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity Open
View article: Additional file 1 of Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity
Additional file 1 of Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity Open
Additional file 1: Table S1. Sex-specific regulation of gene expression related to the proPO activating system.
View article: Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity
Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity Open
Background Sexual selection can have major effects on mating rates and sex-specific costs of mating and may thereby influence sex-differences in immunity as well as associated host-pathogen dynamics. Yet, experimental evidence linking the …
View article: CARCASS SCAVENGING RELAXES THE CHEMICAL-DRIVEN FEMALE INTERFERENCE COMPETITION IN FLOUR BEETLES
CARCASS SCAVENGING RELAXES THE CHEMICAL-DRIVEN FEMALE INTERFERENCE COMPETITION IN FLOUR BEETLES Open
Female-female nonsexual interference competition is rapidly emerging as a major fitness determinant of biased sex-ratio groups with high female density. How do females overcome such competition? We used adult flour beetle Tribolium castane…
View article: Carcass Scavenging Relaxes Chemical-Driven Female Interference Competition
Carcass Scavenging Relaxes Chemical-Driven Female Interference Competition Open
Female-female nonsexual interference competition is rapidly emerging as a major fitness determinant of biased sex-ratio groups with high female density. How do females overcome such competition? We used adult flour beetle Tribolium castane…
View article: THE COSTS AND BENEFITS OF BASAL INFECTION RESISTANCE VS DIVERSE IMMUNE PRIMING RESPONSES IN AN INSECT
THE COSTS AND BENEFITS OF BASAL INFECTION RESISTANCE VS DIVERSE IMMUNE PRIMING RESPONSES IN AN INSECT Open
In insects, basal pathogen resistance and immune priming can evolve as mutually exclusive strategies, with distinct infection outcomes. However, the evolutionary drivers of such diverse immune functions remain poorly understood. Here, we a…
View article: BASAL RESISTANCE AGAINST A PATHOGEN IS MORE BENEFICIAL THAN IMMUNE PRIMING RESPONSES IN FLOUR BEETLES
BASAL RESISTANCE AGAINST A PATHOGEN IS MORE BENEFICIAL THAN IMMUNE PRIMING RESPONSES IN FLOUR BEETLES Open
Insects exhibit various forms of immune responses, including basal resistance to pathogens and a form of immune memory (priming) that can act within or across generations. The evolutionary drivers of such diverse immune functions remain po…
View article: Pathogen susceptibility and fitness costs explain variation in immune priming across natural populations of flour beetles
Pathogen susceptibility and fitness costs explain variation in immune priming across natural populations of flour beetles Open
In many insects, individuals primed with low doses of pathogens early in life have higher survival after exposure to the same pathogen later in life. Yet, our understanding of the evolutionary and ecological history of priming of immune re…
View article: Pathogen susceptibility and fitness costs explain variation in immune priming across natural populations of flour beetles
Pathogen susceptibility and fitness costs explain variation in immune priming across natural populations of flour beetles Open
In many insects, individuals primed with low doses of pathogens live longer after being exposed to the same pathogen later in life. Yet, our understanding of the evolutionary and ecological history of priming of immune response in natural …
View article: Experimental evolution of insect immune memory versus pathogen resistance
Experimental evolution of insect immune memory versus pathogen resistance Open
Under strong pathogen pressure, insects often evolve resistance to infection. Many insects are also protected via immune memory (immune priming), whereby sublethal exposure to a pathogen enhances survival after secondary infection. Theory …
View article: Experimental Evolution of Insect Immune Memory VS. Pathogen Resistance
Experimental Evolution of Insect Immune Memory VS. Pathogen Resistance Open
Under strong pathogen pressure, insects often evolve resistance to infection. Many insects are also protected via immune memory (‘immune priming’), whereby sub-lethal exposure to a pathogen enhances survival after secondary infection. To u…
View article: Correction to ‘Early life inflammation, immune response and ageing’
Correction to ‘Early life inflammation, immune response and ageing’ Open
View article: Early-life inflammation, immune response and ageing
Early-life inflammation, immune response and ageing Open
Age-related diseases are often attributed to immunopathology, which results in self-damage caused by an inappropriate inflammatory response. Immunopathology associated with early-life inflammation also appears to cause faster ageing, altho…
View article: Female Chemical Warfare Drives Fitness Effects of Group Sex Ratio
Female Chemical Warfare Drives Fitness Effects of Group Sex Ratio Open
SUMMARY In animals, skewed sex ratios can affect individual fitness either via sexual interactions (e.g. intersexual conflict or intrasexual mate competition) or non-sexual interactions (e.g. sex-specific resource competition). Because mos…
View article: Supplementary material from "Early-life inflammation, immune response and ageing"
Supplementary material from "Early-life inflammation, immune response and ageing" Open
Age-related diseases are often attributed to immunopathology, which results in self-damage caused by an inappropriate inflammatory response. Immunopathology associated with early-life inflammation also appears to cause faster ageing, altho…
View article: Divergent immune priming responses across flour beetle life stages and populations
Divergent immune priming responses across flour beetle life stages and populations Open
Growing evidence shows that low doses of pathogens may prime the immune response in many insects, conferring subsequent protection against infection in the same developmental stage (within‐life stage priming), across life stages (ontogenic…
View article: Early inflammation, immunopathology and aging
Early inflammation, immunopathology and aging Open
Age-related diseases are often attributed to immunopathology, which results in self-damage caused by an inappropriate inflammatory response. Immunopathology associated with early-life inflammation also appears to cause faster ageing, altho…
View article: Divergent Immune Priming Responses Across Flour Beetle Life Stages and Populations
Divergent Immune Priming Responses Across Flour Beetle Life Stages and Populations Open
Growing evidence shows that low doses of pathogens may prime the immune response in many insects, conferring subsequent protection against infection in the same developmental stage (within life stage priming), across life stages (ontogenic…