In‐Kyu Yoon
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View article: A Multiplex Serological Assay for Quantification of Arbovirus Antibody Kinetics and Neutralizing Antibodies
A Multiplex Serological Assay for Quantification of Arbovirus Antibody Kinetics and Neutralizing Antibodies Open
Arboviruses such as dengue virus (DENV) and chikungunya virus (CHIKV) pose major global health threats. To support serological surveillance and study cross-reactivity, an in-house multiplex bead-based immunoassay was developed to measure I…
View article: Effect of Acute Grape Seed Extract Supplementation on Heart Rate Recovery in Young Individuals
Effect of Acute Grape Seed Extract Supplementation on Heart Rate Recovery in Young Individuals Open
Evidence has suggested that post-exercise heart rate recovery (PHRR) is a useful tool in evaluating cardiac autonomic function. Altered cardiac autonomic function is characterized by heightened sympathetic activation and the abnormal react…
View article: Effect of Aerobic Exercise with Blood Flow Restriction on Postexercise Hypotension in Young Adults: The Role of Histamine Receptors
Effect of Aerobic Exercise with Blood Flow Restriction on Postexercise Hypotension in Young Adults: The Role of Histamine Receptors Open
We tested hypothesis that aerobic exercise with blood flow restriction (BFR) induced postexercise hypotension (PEH), and the reduction in blood pressure (BP) was due to peripheral vasodilation via the histamine receptors. Ten male subjects…
View article: Reconstruction of antibody dynamics and infection histories to evaluate dengue risk
Reconstruction of antibody dynamics and infection histories to evaluate dengue risk Open
As with many pathogens, most dengue infections are subclinical and therefore unobserved 1 . Coupled with limited understanding of the dynamic behaviour of potential serological markers of infection, this observational problem has wide-rang…
View article: The mRNA vaccine development landscape for infectious diseases
The mRNA vaccine development landscape for infectious diseases Open
View article: Novel Assay to Measure Seroprevalence of Zika Virus in the Philippines
Novel Assay to Measure Seroprevalence of Zika Virus in the Philippines Open
Zika virus (ZIKV) is a member of the Flaviviridae family, which includes other clinically notable viruses such as the 4 dengue virus serotypes (DENV-1-4). Distinguishing DENVs from ZIKV using the established serologic assays widely used fo…
View article: Evaluation of the extended efficacy of the Dengvaxia vaccine against symptomatic and subclinical dengue infection
Evaluation of the extended efficacy of the Dengvaxia vaccine against symptomatic and subclinical dengue infection Open
View article: Precision Tracing of Household Dengue Spread Using Inter- and Intra-Host Viral Variation Data, Kamphaeng Phet, Thailand
Precision Tracing of Household Dengue Spread Using Inter- and Intra-Host Viral Variation Data, Kamphaeng Phet, Thailand Open
Dengue control approaches are best informed by granular spatial epidemiology of these viruses, yet reconstruction of inter- and intra-household transmissions is limited when analyzing case count, serologic, or genomic consensus sequence da…
View article: Estimating the Force of Infection for Dengue Virus Using Repeated Serosurveys, Ouagadougou, Burkina Faso
Estimating the Force of Infection for Dengue Virus Using Repeated Serosurveys, Ouagadougou, Burkina Faso Open
Because of limited data on dengue virus in Burkina Faso, we conducted 4 consecutive age-stratified longitudinal serologic surveys, ≈6 months apart, among persons 1-55 years of age, during June 2015-March 2017, which included a 2016 outbrea…
View article: Determining dengue virus serostatus by indirect IgG ELISA compared with focus reduction neutralisation test in children in Cebu, Philippines: a prospective population-based study
Determining dengue virus serostatus by indirect IgG ELISA compared with focus reduction neutralisation test in children in Cebu, Philippines: a prospective population-based study Open
View article: Performance of Dried Blood Spots Compared with Serum Samples for Measuring Dengue Seroprevalence in a Cohort of Children in Cebu, Philippines
Performance of Dried Blood Spots Compared with Serum Samples for Measuring Dengue Seroprevalence in a Cohort of Children in Cebu, Philippines Open
Dengue seroprevalence data are useful for understanding epidemiologic trends and transmission dynamics, and for making decisions about implementation of dengue control programs. A logistical challenge to seroprevalence surveys is the colle…
View article: Clinical and epidemiologic characteristics associated with dengue fever in Mombasa, Kenya
Clinical and epidemiologic characteristics associated with dengue fever in Mombasa, Kenya Open
View article: Evaluation of a new point-of-care test to determine prior dengue infection for potential use in pre-vaccination screening
Evaluation of a new point-of-care test to determine prior dengue infection for potential use in pre-vaccination screening Open
The insufficient specificity and sensitivity (particularly in the detection of a previous monotypic dengue infection) would render the test, in its current state, inadequate for pre-vaccination screening. Considering its user-friendly inte…
View article: Vector and cell-culture passaging of dengue clinical samples for virus isolation and amplification does not significantly change genome consensus or frequencies of intra-host viral variants
Vector and cell-culture passaging of dengue clinical samples for virus isolation and amplification does not significantly change genome consensus or frequencies of intra-host viral variants Open
Intra-host single nucleotide variants (iSNVs) have been increasingly used in genomic epidemiology to increase phylogenetic resolution and reconstruct fine-scale outbreak dynamics. These analyses are preferably done on sequence data from di…
View article: Next-generation sequencing of 11 HLA loci in a large dengue vaccine cohort from the Philippines
Next-generation sequencing of 11 HLA loci in a large dengue vaccine cohort from the Philippines Open
View article: Virological and Immunological Outcomes in Rhesus Monkeys after Exposure to Dengue Virus–Infected Aedes aegypti Mosquitoes
Virological and Immunological Outcomes in Rhesus Monkeys after Exposure to Dengue Virus–Infected Aedes aegypti Mosquitoes Open
This study describes the natural history of dengue virus (DENV) infection in rhesus monkeys exposed to the bites of DENV-infected Aedes aegypti mosquitoes. Dengue virus-infected mosquitoes were generated by either intrathoracic inoc…
View article: An Innovative, Prospective, Hybrid Cohort-Cluster Study Design to Characterize Dengue Virus Transmission in Multigenerational Households in Kamphaeng Phet, Thailand
An Innovative, Prospective, Hybrid Cohort-Cluster Study Design to Characterize Dengue Virus Transmission in Multigenerational Households in Kamphaeng Phet, Thailand Open
Difficulties inherent in the identification of immune correlates of protection or severe disease have challenged the development and evaluation of dengue vaccines. There persist substantial gaps in knowledge about the complex effects of ag…
View article: Determining Dengue Serostatus by Indirect IgG ELISA Compared to Virus Neutralization Test in a Cohort of Children in Cebu (Philippines) Prior to a Mass Dengue Vaccination
Determining Dengue Serostatus by Indirect IgG ELISA Compared to Virus Neutralization Test in a Cohort of Children in Cebu (Philippines) Prior to a Mass Dengue Vaccination Open
View article: Clinical and epidemiologic characteristics associated with dengue during and outside the 2016 outbreak identified in health facility-based surveillance in Ouagadougou, Burkina Faso
Clinical and epidemiologic characteristics associated with dengue during and outside the 2016 outbreak identified in health facility-based surveillance in Ouagadougou, Burkina Faso Open
Dengue virus is an important pathogen in Burkina Faso, accounting for a substantial proportion of non-malarial fevers both during and outside outbreak, but is only infrequently suspected by clinicians. Additional longitudinal data would he…
View article: Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels
Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels Open
MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV spike protein, with further groups receiving control vaccinations. …
View article: A review of Dengvaxia®: development to deployment
A review of Dengvaxia®: development to deployment Open
Dengue is the world’s most prevalent and important arboviral disease. More than 50% of the world’s population lives at daily risk of infection and it is estimated more than 95 million people a year seek medical care following infection. Se…
View article: Influenza virus seroincidence in a cohort of healthy and high-risk children enrolled in infancy, Bangkok, Thailand
Influenza virus seroincidence in a cohort of healthy and high-risk children enrolled in infancy, Bangkok, Thailand Open
Influenza virus infection is common during the first two years of life among Thai children. A large proportion of infections may not be detected using the ARI case definition.
View article: Association between semi-quantitative microbial load and respiratory symptoms among Thai military recruits: a prospective cohort study
Association between semi-quantitative microbial load and respiratory symptoms among Thai military recruits: a prospective cohort study Open
View article: Zika Virus Infection in Syrian Golden Hamsters and Strain 13 Guinea Pigs
Zika Virus Infection in Syrian Golden Hamsters and Strain 13 Guinea Pigs Open
To evaluate potential immunocompetent small animal models of Zika virus (ZIKV) infection, we inoculated Syrian golden hamsters (subcutaneously or intraperitoneally) and strain 13 guinea pigs (intraperitoneally) with Senegalese ZIKV strain …
View article: Additional file 1: of Association between semi-quantitative microbial load and respiratory symptoms among Thai military recruits: a prospective cohort study
Additional file 1: of Association between semi-quantitative microbial load and respiratory symptoms among Thai military recruits: a prospective cohort study Open
Dataset. Title of data: Semi-quantitative microbial load in throat and nasal swab samples from Thai Army recruits. Description of data: Semi-quantitative microbial load in non-acute and acute throat and nasal swab samples from Thai Army re…
View article: Development of Middle East Respiratory Syndrome Coronavirus vaccines – advances and challenges
Development of Middle East Respiratory Syndrome Coronavirus vaccines – advances and challenges Open
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an emerging pathogen with the potential to pose a threat to global public health. Sporadic cases and outbreaks continue to be reported in the Middle East, and case fatality rates r…
View article: Dengue Virus Serotypes 1 and 2 Responsible for Major Dengue Outbreaks in Nepal: Clinical, Laboratory, and Epidemiological Features
Dengue Virus Serotypes 1 and 2 Responsible for Major Dengue Outbreaks in Nepal: Clinical, Laboratory, and Epidemiological Features Open
Dengue virus (DENV) is expanding toward previously nonendemic areas. DENV has recently been introduced in Nepal with limited information. We report the clinical features and serotype distribution of DENV in Nepal during the 2010 outbreaks.…
View article: Live-attenuated tetravalent dengue vaccines: The needs and challenges of post-licensure evaluation of vaccine safety and effectiveness
Live-attenuated tetravalent dengue vaccines: The needs and challenges of post-licensure evaluation of vaccine safety and effectiveness Open
Since December 2015, the first dengue vaccine has been licensed in several Asian and Latin American countries for protection against disease from all four dengue virus serotypes. While the vaccine demonstrated an overall good safety and ef…
View article: The value of multi-country joint regulatory reviews: The experience of a WHO joint technical consultation on the CYD-TDV (Dengvaxia®) dossier
The value of multi-country joint regulatory reviews: The experience of a WHO joint technical consultation on the CYD-TDV (Dengvaxia®) dossier Open
View article: Polytopic vaccination with a live-attenuated dengue vaccine enhances B-cell and T-cell activation, but not neutralizing antibodies
Polytopic vaccination with a live-attenuated dengue vaccine enhances B-cell and T-cell activation, but not neutralizing antibodies Open