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View article: CB1 receptor activation and inhibition differentially modulate cognitive deficits and neuropathology in 3xTg-AD mice
CB1 receptor activation and inhibition differentially modulate cognitive deficits and neuropathology in 3xTg-AD mice Open
Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) deposition, tau hyperphosphorylation, neuroinflammation, oxidative stress, and progressive neuronal loss. The endocannabinoid system regulates synaptic function, inflammation, and…
View article: Evaluation of antidepressant and sleep-promoting effects of cordycepin in a menopause-like stress model
Evaluation of antidepressant and sleep-promoting effects of cordycepin in a menopause-like stress model Open
The menopausal transition is often accompanied by mood disturbances and sleep disorders, exacerbated by estrogen deficiency and chronic stress. Although hormone replacement therapy (HRT) is effective, its use is limited by safety concerns,…
View article: Fermented rice germ extract with high concentration of gamma-aminobutyric acid enhances pentobarbital-induced sleep via GABAergic system in rats
Fermented rice germ extract with high concentration of gamma-aminobutyric acid enhances pentobarbital-induced sleep via GABAergic system in rats Open
In modern societies, insomnia stands out as a widespread health concern. Gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, can exert hypnotic effects. However, despite various clinical trials conducted, scientific evidence re…
View article: Hippocampal serotonin levels by microdialysis and locomotor activity following intra-MR injections of drugs.
Hippocampal serotonin levels by microdialysis and locomotor activity following intra-MR injections of drugs. Open
Hippocampal serotonin levels by microdialysis and locomotor activity following intra-MR injections of drugs.
View article: Anti-inflammatory effect of grounding mat on trimethyltin-induced neurotoxicity rats
Anti-inflammatory effect of grounding mat on trimethyltin-induced neurotoxicity rats Open
Grounding, the practice of direct contact with the Earth’s surface, has been explored for its potential to alleviate inflammation and neurotoxicity. Trimethyltin (TMT) is a potent neurotoxic compound known for inducing severe central nervo…
View article: Interventions for Neural Plasticity in Stroke Recovery
Interventions for Neural Plasticity in Stroke Recovery Open
Stroke is a leading cause of long-term disability, and enhancing neural plasticity is a central strategy in promoting functional recovery. This review examines a range of interventions that target plasticity to improve outcomes in stroke s…
View article: GABALAGEN Alleviates Stress-Induced Sleep Disorders in Rats
GABALAGEN Alleviates Stress-Induced Sleep Disorders in Rats Open
(1) Background: Gamma-aminobutyric acid (GABA) is an amino acid and the primary inhibitory neurotransmitter in the brain. GABA has been shown to reduce stress and promote sleep. GABALAGEN (GBL) is the product of fermented fish collagen by …
View article: Neuroprotective Effect of Ixeris dentata Extract on Trimethyltin-Induced Memory Impairment in Rats
Neuroprotective Effect of Ixeris dentata Extract on Trimethyltin-Induced Memory Impairment in Rats Open
Alzheimer’s disease (AD) is a representative neurodegenerative disease characterized by the structural and functional degeneration of neurons. The present study investigated the neuroprotective effect of Ixeris dentata (ID) extract on trim…
View article: GABALAGEN Facilitates Pentobarbital-Induced Sleep by Modulating the Serotonergic System in Rats
GABALAGEN Facilitates Pentobarbital-Induced Sleep by Modulating the Serotonergic System in Rats Open
Gamma-aminobutyric acid (GABA) is one of the inhibitory neurotransmitters with beneficial effects including sedative properties. However, despite various clinical trials, scientific evidence regarding the impact on sleep of orally ingested…
View article: Effect of Earthing Mats on Sleep Quality in Rats
Effect of Earthing Mats on Sleep Quality in Rats Open
Grounding, a therapeutic technique involving direct contact with the earth, has been proposed by various studies to potentially have beneficial effects on pressure, sleep quality, stress, inflammation, and mood. However, the scientific evi…
View article: Antidepressant Effect of Enzymatic Porcine Placenta Hydrolysate in Repeated Immobilization Stress-Induced Ovariectomized Female Mice
Antidepressant Effect of Enzymatic Porcine Placenta Hydrolysate in Repeated Immobilization Stress-Induced Ovariectomized Female Mice Open
When postmenopausal women are under stress conditions, this exacerbates mood disorders and issues with neuroimmune systems. The porcine placenta is known to relieve menopausal depression in clinical trials, but its underlying mechanisms fo…
View article: GABALAGEN Alleviates Stress-Induced Sleep Disorder in Rats
GABALAGEN Alleviates Stress-Induced Sleep Disorder in Rats Open
(1) Background: Gamma-aminobutyric acid (GABA) is one of the inhibitory neurotransmitters with beneficial effects including sedative property. However, despite various clinical trials, scientific evidence regarding the impact of orally ing…
View article: Editorial: Stress, pain or drug addiction: epigenetics, biological mechanisms and therapeutics
Editorial: Stress, pain or drug addiction: epigenetics, biological mechanisms and therapeutics Open
EDITORIAL article Front. Mol. Neurosci., 19 October 2023Sec. Neuroplasticity and Development Volume 16 - 2023 | https://doi.org/10.3389/fnmol.2023.1298870
View article: SEDATIVE-HYPNOTIC EFFECTS OF GLYCINE MAX MERR. EXTRACT AND ITS ACTIVE INGREDIENT GENISTEIN ON ELECTRIC-SHOCK-INDUCED SLEEP DISTURBANCES IN RATS
SEDATIVE-HYPNOTIC EFFECTS OF GLYCINE MAX MERR. EXTRACT AND ITS ACTIVE INGREDIENT GENISTEIN ON ELECTRIC-SHOCK-INDUCED SLEEP DISTURBANCES IN RATS Open
View article: ANTIDEPRESSANT EFFECT OF FERMENTED PORCINE PLACENTA IN REPEAT-ED IMMOBILIZATION STRESS–INDUCED OVARIECTOMIZED FEMALE MICE
ANTIDEPRESSANT EFFECT OF FERMENTED PORCINE PLACENTA IN REPEAT-ED IMMOBILIZATION STRESS–INDUCED OVARIECTOMIZED FEMALE MICE Open
View article: The effects of physical exercise therapy on weight control: its regulation of adipocyte physiology and metabolic capacity
The effects of physical exercise therapy on weight control: its regulation of adipocyte physiology and metabolic capacity Open
Factors associated with increased body mass, including dyslipidemia, hypertension, insulin resistance, vascular endothelial dysfunction and sleep disorders, may contribute to the exacerbation of cardiovascular disease. These health problem…
View article: Sedative-Hypnotic Effects of Glycine max Merr. Extract and Its Active Ingredient Genistein on Electric-Shock-Induced Sleep Disturbances in Rats
Sedative-Hypnotic Effects of Glycine max Merr. Extract and Its Active Ingredient Genistein on Electric-Shock-Induced Sleep Disturbances in Rats Open
Glycine max Merr. (GM) is a functional food that provides many beneficial phytochemicals. However, scientific evidence of its antidepressive and sedative activities is scarce. The present study was designed to investigate the antidepressiv…
View article: Regulatory role of cytokines on etiology of depression in animal models: their biological mechanisms and clinical implication with physical exercise
Regulatory role of cytokines on etiology of depression in animal models: their biological mechanisms and clinical implication with physical exercise Open
It has been known that chronic psychological or physical stress elicits depressive behaviors (learned helplessness, anhedonia, anxiety, etc.) and also activates to release proinflammatory cytokines in the brain. Especially, postmenopausal …
View article: The Effect of Earthing Mat on Stress-Induced Anxiety-like Behavior and Neuroendocrine Changes in the Rat
The Effect of Earthing Mat on Stress-Induced Anxiety-like Behavior and Neuroendocrine Changes in the Rat Open
Grounding is a therapeutic technique that involves doing activities that “ground” or electrically reconnect us to the earth. The physiological effects of grounding have been reported from a variety of perspectives such as sleep or pain. Ho…
View article: Anti-Obesity Effect of Chitoglucan in High-Fat-Induced Obesity Mice
Anti-Obesity Effect of Chitoglucan in High-Fat-Induced Obesity Mice Open
Background: Chitoglucan (CG) is a bioactive component obtained from Flammulina velutipes Sing, an edible mushroom, which is known to have an anti-obesity effect. However, its biological and hormonal activities in alleviating obesity throug…
View article: A Randomized Double-Blind, Placebo-Controlled Study on Anti-Stress Effects of Nelumbinis Semen
A Randomized Double-Blind, Placebo-Controlled Study on Anti-Stress Effects of Nelumbinis Semen Open
Introduction: Depression is a serious and common mental disease that causes low mood and loss of interest in activities. Nelumbinis semen (NS) has been widely used as a treatment for depression for hundreds of years in many Asian countries…
View article: Neuroprotective effects of ex vivo-expanded regulatory T cells on trimethyltin-induced neurodegeneration in mice
Neuroprotective effects of ex vivo-expanded regulatory T cells on trimethyltin-induced neurodegeneration in mice Open
View article: Effect of Modified Yukmijihwang-Tang on Sleep Quality in the Rat
Effect of Modified Yukmijihwang-Tang on Sleep Quality in the Rat Open
Many plants have been used in Korean medicine for treating insomnia. However, scientific evidence for their sedative activity has not been fully investigated. Thus, this study was carried out to investigate the sedative effects of the extr…
View article: Distinct functions of S-ketamine and R-ketamine in mediating biobehavioral processes of drug dependency: comments on Bonaventura et al.
Distinct functions of S-ketamine and R-ketamine in mediating biobehavioral processes of drug dependency: comments on Bonaventura et al. Open
View article: Anti-Inflammatory Effect of Three Isolated Compounds of Physalis alkekengi var. franchetii (PAF) in Lipopolysaccharide-Activated RAW 264.7 Cells
Anti-Inflammatory Effect of Three Isolated Compounds of Physalis alkekengi var. franchetii (PAF) in Lipopolysaccharide-Activated RAW 264.7 Cells Open
(1) Background: Three isolated compounds from Physalis alkekengi var. franchetii (PAF) have been investigated to possess a variety of biological activities. Their structures were elucidated by spectroscopic analysis (Ultraviolet (UV), High…
View article: Sedative–Hypnotic Activity of the Water Extracts of Coptidis Rhizoma in Rodents
Sedative–Hypnotic Activity of the Water Extracts of Coptidis Rhizoma in Rodents Open
Many medicinal plants have been used in Asia for treating a variety of mental diseases, including insomnia and depression. However, their sedative–hypnotic effects and mechanisms have not been clarified yet. Accordingly, the objective of t…
View article: Pre/post-natal exposure to microplastic as a potential risk factor for autism spectrum disorder
Pre/post-natal exposure to microplastic as a potential risk factor for autism spectrum disorder Open
View article: Neuronal mechanisms of ginseng on antiobesity effects: implication of its synergistic benefits with physical exercise
Neuronal mechanisms of ginseng on antiobesity effects: implication of its synergistic benefits with physical exercise Open
Obesity is a chronic disease of increasing prevalence in most countries, which leads to substantial increase in morbidity, and mortality in association with diabetes, hyperlipidaemia, hypertension, and other cardiovascular diseases. Many f…
View article: Effect of Hibiscus syriacus Linnaeus extract and its active constituent, saponarin, in animal models of stress-induced sleep disturbances and pentobarbital-induced sleep
Effect of Hibiscus syriacus Linnaeus extract and its active constituent, saponarin, in animal models of stress-induced sleep disturbances and pentobarbital-induced sleep Open
View article: Neuroprotective Effects of Ex Vivo Expanded Regulatory T Cells on Trimethyltin Induced Neurodegeneration in Mice
Neuroprotective Effects of Ex Vivo Expanded Regulatory T Cells on Trimethyltin Induced Neurodegeneration in Mice Open
BackgroundTrimethyltin (TMT) is a potent neurotoxicant that leads to hippocampal neurodegeneration. Regulatory T cells (Tregs) play an important role in maintaining the immune balance in the central nervous system (CNS), but their activiti…