Inácio Mandomando
YOU?
Author Swipe
View article: Epidemiology and outcomes of pediatric fever in a rural district of Southern Mozambique: 17 years of morbidity surveillance
Epidemiology and outcomes of pediatric fever in a rural district of Southern Mozambique: 17 years of morbidity surveillance Open
Background Pediatric febrile illnesses remain a leading cause of healthcare visits, morbidity, and mortality in low-resource settings. Their etiological diagnosis and outcome evaluation is challenging as available tools are limited. Hereby…
View article: Performance evaluation of the diaxxoPCR system for rapid and user-friendly stool-based diagnosis of trichuriasis, ascariasis and strongyloidiasis in Mozambique
Performance evaluation of the diaxxoPCR system for rapid and user-friendly stool-based diagnosis of trichuriasis, ascariasis and strongyloidiasis in Mozambique Open
Background Nucleic acid amplification tests have shown promising results for the diagnosis of soil-transmitted helminths (STH). The implementation of real-time PCR (qPCR) in low-resource settings is, however, still hampered by multiple log…
View article: Assessing the diagnostic value of qPCR for Trichuris trichiura: sub-analysis of a multi-country clinical trial to determine the efficacy of albendazole compared to an albendazole-ivermectin fixed dose combination
Assessing the diagnostic value of qPCR for Trichuris trichiura: sub-analysis of a multi-country clinical trial to determine the efficacy of albendazole compared to an albendazole-ivermectin fixed dose combination Open
Trichuris trichiura remains a major global public health concern, particularly in low-resource settings where standard anthelmintic regimens are limited. This study evaluated the diagnostic performance of real-time PCR (qPCR) compared to t…
View article: Whole-genome analysis of rotavirus G1P[8] and other Wa-like strains in Mozambican children: evidence of genetic variations of pre-vaccine G1P[8] strains from Manhiça, Mozambique
Whole-genome analysis of rotavirus G1P[8] and other Wa-like strains in Mozambican children: evidence of genetic variations of pre-vaccine G1P[8] strains from Manhiça, Mozambique Open
The Rotarix® (GlaxoSmithKline, Rixenstart, Belgium) vaccine was adopted into the Expanded Program on Immunization in Mozambique in September 2015, and G1P[8] strains were frequent pre- and post-vaccine introduction in some regions of the c…
View article: Elucidating Delays in Illness Recognition, Healthcare Seeking, and Healthcare Provision for Stillbirths and Neonatal Deaths in Seven Low- and Middle-Income Countries
Elucidating Delays in Illness Recognition, Healthcare Seeking, and Healthcare Provision for Stillbirths and Neonatal Deaths in Seven Low- and Middle-Income Countries Open
An estimated 1.9 million stillbirths and 2.3 million neonatal deaths occurred globally in 2023, disproportionately clustered in sub-Saharan Africa and South Asia. We aimed to determine the frequency of delays in illness recognition, health…
View article: Diagnostic accuracy of a simplified minimally invasive tissue sampling protocol for stillbirths in low-resource settings
Diagnostic accuracy of a simplified minimally invasive tissue sampling protocol for stillbirths in low-resource settings Open
Background Stillbirth rates remain unacceptably high in low- and middle-income countries (LMICs). Understanding the causes of death (CoD) is mandatory to develop effective strategies to reduce this high mortality. Minimally invasive tissue…
View article: Causes of stillbirth in sub-Saharan Africa and South Asia: Findings from Child Health and Mortality Prevention Surveillance, 2016-2023
Causes of stillbirth in sub-Saharan Africa and South Asia: Findings from Child Health and Mortality Prevention Surveillance, 2016-2023 Open
Summary Background Globally, an estimated 1.9 million stillbirths occur annually, yet significant knowledge gaps exist regarding the causes of stillbirths, particularly in high-burden regions. We investigated fetal and maternal conditions …
View article: Reliability of minimally invasive tissue sampling (MITS) for cause of death determination up to 72 h postmortem
Reliability of minimally invasive tissue sampling (MITS) for cause of death determination up to 72 h postmortem Open
Minimally invasive tissue sampling (MITS) is a postmortem technique that involves percutaneous needle sampling of key organs and fluids, offering a practical alternative to complete autopsy for determining cause of death (CoD), a critical …
View article: Major Causes of Perinatal and Paediatric Mortality in Sub‐Saharan Africa and South Asia: Adjustment for Selection Bias in the <scp>CHAMPS</scp> Network
Major Causes of Perinatal and Paediatric Mortality in Sub‐Saharan Africa and South Asia: Adjustment for Selection Bias in the <span>CHAMPS</span> Network Open
Background Studies of child mortality that employ minimally invasive tissue sampling (MITS) produce highly accurate cause of death data; however, selection bias may render these as non‐representative of their underlying populations. Object…
View article: Investigation of mobile genetic elements and their association with antibiotic resistance genes in clinical pathogens worldwide
Investigation of mobile genetic elements and their association with antibiotic resistance genes in clinical pathogens worldwide Open
Objectives Antimicrobial-resistant bacteria are a major global health threat. Mobile genetic elements (MGEs) have been crucial for spreading resistance to new bacterial species, including human pathogens. Understanding how MGEs promote res…
View article: Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets
Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets Open
View article: Systematic review of risk assessment tools for post-discharge mortality among children in sub-Saharan Africa
Systematic review of risk assessment tools for post-discharge mortality among children in sub-Saharan Africa Open
Post-discharge mortality is increasingly recognized as a major contributor to the high burden of childhood mortality in sub-Saharan Africa. Accurate identification of children at risk for post-discharge mortality is critically important to…
View article: Use of minimally invasive tissue sampling to determine the contribution of diarrheal diseases to under-five mortality and associated co-morbidities and co-infections in children with fatal diarrheal diseases in Africa and Bangladesh
Use of minimally invasive tissue sampling to determine the contribution of diarrheal diseases to under-five mortality and associated co-morbidities and co-infections in children with fatal diarrheal diseases in Africa and Bangladesh Open
Achieving the Sustainable Development Goal of reducing child mortality to <25 deaths per 1000 live births by 2030 requires strategies to prevent diarrheal disease-related morbidity and mortality. Accurate etiological diagnosis is essential…
View article: Molecular diversity of Giardia duodenalis in children under 5 years from the Manhiça district, Southern Mozambique enrolled in a matched case-control study on the aetiology of diarrhoea
Molecular diversity of Giardia duodenalis in children under 5 years from the Manhiça district, Southern Mozambique enrolled in a matched case-control study on the aetiology of diarrhoea Open
Giardia duodenalis is an enteric parasite commonly detected in children. Exposure to this organism may lead to asymptomatic or symptomatic infection. Additionally, early-life infections by this protozoan have been associated with impaired …
View article: Investigating the Role of Cytomegalovirus as a Cause of Stillbirths and Child Deaths in Low- and Middle-Income Countries Through Postmortem Minimally Invasive Tissue Sampling
Investigating the Role of Cytomegalovirus as a Cause of Stillbirths and Child Deaths in Low- and Middle-Income Countries Through Postmortem Minimally Invasive Tissue Sampling Open
Background There is paucity of information on the role of cytomegalovirus (CMV) infection as a cause of stillbirths or childhood deaths in low- and middle-income countries (LMICs). We investigated attribution of CMV disease in the causal p…
View article: Structural basis of aggregative adherence fimbriae II interactions with sialic acid, mucin, and human intestinal cells
Structural basis of aggregative adherence fimbriae II interactions with sialic acid, mucin, and human intestinal cells Open
Enteroaggregative Escherichia coli (EAEC) is a common cause of diarrhea worldwide and is associated with growth faltering in developing countries. EAEC are defined by a characteristic adherence pattern mediated by the aggregative adherence…
View article: Candida skin colonization among critically-ill neonates, children and adults admitted to tertiary and district hospitals in Mozambique
Candida skin colonization among critically-ill neonates, children and adults admitted to tertiary and district hospitals in Mozambique Open
Background: Pathogenic fungi are responsible for a largely silent epidemic, often hidden killers causing substantial morbidity and mortality in susceptible individuals. The disease burden caused by fungal pathogens in Mozambique may be sub…
View article: Paediatric healthcare in Manhiça district through a gender lens: a retrospective analysis of 17 years of morbidity and demographic surveillance data
Paediatric healthcare in Manhiça district through a gender lens: a retrospective analysis of 17 years of morbidity and demographic surveillance data Open
Girls had fewer referrals and admissions to hospital in Manhiça district, but they were also less likely to present with severe manifestations. Other studied indicators of healthcare access and provision were overall similar for boys and g…
View article: Post-Mortem Investigation of Role of Endemic Human Coronaviruses (HCoV-NL63, OC43, 229E and HKU-1) in the Causal Pathway to Death Amongst Children Under Five in Low- and Middle-Income Countries: Findings from the Child Health and Mortality Prevention Surveillance (CHAMPS)
Post-Mortem Investigation of Role of Endemic Human Coronaviruses (HCoV-NL63, OC43, 229E and HKU-1) in the Causal Pathway to Death Amongst Children Under Five in Low- and Middle-Income Countries: Findings from the Child Health and Mortality Prevention Surveillance (CHAMPS) Open
View article: Genomic analysis of DS-1-like human rotavirus A strains uncovers genetic relatedness of NSP4 gene with animal strains in Manhiça District, Southern Mozambique
Genomic analysis of DS-1-like human rotavirus A strains uncovers genetic relatedness of NSP4 gene with animal strains in Manhiça District, Southern Mozambique Open
View article: Contribution of malnutrition to infant and child deaths in Sub-Saharan Africa and South Asia
Contribution of malnutrition to infant and child deaths in Sub-Saharan Africa and South Asia Open
Introduction Malnutrition contributes to 45% of all childhood deaths globally, but these modelled estimates lack direct measurements in countries with high malnutrition and under-5 mortality rates. We investigated malnutrition’s role in in…
View article: Rotavirus Vaccine Effectiveness Stratified By National-Level Characteristics: An Introduction to the 24-Country MNSSTER-V Project, 2007–2023
Rotavirus Vaccine Effectiveness Stratified By National-Level Characteristics: An Introduction to the 24-Country MNSSTER-V Project, 2007–2023 Open
Background Rotavirus vaccines are moderately protective against illness in settings with high compared with low mortality rates. Vaccine effectiveness (VE) evaluations may clarify our understanding of these disparities, but estimates among…
View article: Etiologies and comorbidities of meningitis deaths in children under 5 years in high-mortality settings: Insights from the CHAMPS Network in the post-pneumococcal vaccine era
Etiologies and comorbidities of meningitis deaths in children under 5 years in high-mortality settings: Insights from the CHAMPS Network in the post-pneumococcal vaccine era Open
Our study highlights meningitis as a significant contributor to under-5 mortality in low-middle-income countries. The prominent role of K. pneumoniae and A. baumannii, particularly in healthcare settings and specific regions, highlights th…
View article: Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets
Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets Open
Soil-transmitted helminths (STHs) are intestinal pathogens affecting over a billion people worldwide. STH control relies on microsopy-based diagnostics to monitor parasite prevalence and enable post-treatment surveillance, however, molecul…
View article: Child Health and Mortality Prevention Surveillance (CHAMPS): Manhiça site description, Mozambique
Child Health and Mortality Prevention Surveillance (CHAMPS): Manhiça site description, Mozambique Open
The Manhiça Health Research Centre (Manhiça HDSS) was established in 1996 in Manhiça, a rural district at Maputo Province in the southern part of Mozambique with approximately 49,000 inhabited households, a total population of 209.000 indi…
View article: Child Health and Mortality Prevention Surveillance (CHAMPS): Manhiça site description, Mozambique
Child Health and Mortality Prevention Surveillance (CHAMPS): Manhiça site description, Mozambique Open
The Manhiça Health Research Centre (Manhiça HDSS) was established in 1996 in Manhiça, a rural district at Maputo Province in the southern part of Mozambique with approximately 49,000 inhabited households, a total population of 209.000 indi…
View article: Neurological Symptoms and Cause of Death Among Young Children in Low- and Middle-Income Countries
Neurological Symptoms and Cause of Death Among Young Children in Low- and Middle-Income Countries Open
Importance The emergence of acute neurological symptoms in children necessitates immediate intervention. Although low- and middle-income countries (LMICs) bear the highest burden of neurological diseases, there is a scarcity of diagnostic …
View article: Orphanhood in Manhiça district, Mozambique: causes, trends, and impacts on living arrangements and migration over 24 years of continuous demographic surveillance (1998-2021)
Orphanhood in Manhiça district, Mozambique: causes, trends, and impacts on living arrangements and migration over 24 years of continuous demographic surveillance (1998-2021) Open
Background Orphanhood is among the major socio-economic challenges in low- and middle-income countries, but measuring the trends, causes, and consequences of orphanhood on children in these countries has been difficult due to lack of adequ…
View article: Comparison of causes of stillbirth and child deaths as determined by verbal autopsy and minimally invasive tissue sampling
Comparison of causes of stillbirth and child deaths as determined by verbal autopsy and minimally invasive tissue sampling Open
In resource-limited settings where vital registration and medical death certificates are unavailable or incomplete, verbal autopsy (VA) is often used to attribute causes of death (CoD) and prioritize resource allocation and interventions. …
View article: Detection of Enteric Viruses in Children under Five Years of Age before and after Rotavirus Vaccine Introduction in Manhiça District, Southern Mozambique, 2008–2019
Detection of Enteric Viruses in Children under Five Years of Age before and after Rotavirus Vaccine Introduction in Manhiça District, Southern Mozambique, 2008–2019 Open
Enteric viruses are the leading cause of diarrhoea in children <5 years. Despite existing studies describing rotavirus diarrhoea in Mozambique, data on other enteric viruses remains scarce, especially after rotavirus vaccine introduction. …