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View article: qMAP enabled microanatomical mapping of human skin aging
qMAP enabled microanatomical mapping of human skin aging Open
Aging is a major driver of diseases in humans. Identifying features associated with aging is essential for designing robust intervention strategies and discovering novel biomarkers of aging. Extensive studies at both the molecular and orga…
View article: Immune cell subsets in interface cutaneous immune‐related adverse events associated with <scp>anti‐PD</scp>‐1 therapy resemble acute graft versus host disease more than lichen planus
Immune cell subsets in interface cutaneous immune‐related adverse events associated with <span>anti‐PD</span>‐1 therapy resemble acute graft versus host disease more than lichen planus Open
Background Checkpoint immunotherapy is frequently associated with cutaneous immune‐related adverse events (cirAEs), and among those, the most common subtype shows interface reaction patterns that have been likened to lichen planus (LP); ho…
View article: Analysis of multispectral imaging with the AstroPath platform informs efficacy of PD-1 blockade
Analysis of multispectral imaging with the AstroPath platform informs efficacy of PD-1 blockade Open
Astronomy accelerates tumor imaging Immunohistochemical stains for individual markers revolutionized diagnostic pathology decades ago but cannot capture enough information to accurately predict response to immunotherapy. Newer multiplex im…
View article: AB011. A Gottron’s papule mimicker: an unusual presentation of porokeratosis plantaris palmaris et disseminata
AB011. A Gottron’s papule mimicker: an unusual presentation of porokeratosis plantaris palmaris et disseminata Open
A 52-year-old woman with a past medical history of breast cancer presented for evaluation of a scaly eruption on bilateral dorsal and palmar hands for the preceding seven months. The patient also noted scaling of her right foot, hallux, an…
View article: Total Penis, Scrotum, and Lower Abdominal Wall Transplantation
Total Penis, Scrotum, and Lower Abdominal Wall Transplantation Open
Total Penis, Scrotum, and Lower Abdominal Wall Transplantation This letter describes transplantation of the penis, scrotum, and lower abdominal wall in an injured veteran who had sustained traumati...
View article: Cutaneous Eruptions in Patients Receiving Immune Checkpoint Blockade
Cutaneous Eruptions in Patients Receiving Immune Checkpoint Blockade Open
Cutaneous eruptions are among the most common immune-related adverse events (irAEs) associated with anti-programmed cell death protein 1/programmed cell death ligand 1 therapy, and are often clinically and histologically characterized as l…
View article: The immune reconstitution of the skin following sex‐mismatched allogeneic haematopoietic stem cell transplant: a prospective case series utilizing fluorescence <i>in situ</i> hybridization and immunohistochemistry
The immune reconstitution of the skin following sex‐mismatched allogeneic haematopoietic stem cell transplant: a prospective case series utilizing fluorescence <i>in situ</i> hybridization and immunohistochemistry Open
Graft versus host disease (GVHD) is a common, morbid, and potentially fatal complication of allogeneic hematopoietic stem cell transplantation (aHSCT).1-3 The exact timing of the arrival of donor-derived immune cells and their profile in t…