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View article: Shared requirement for MYC upstream super-enhancer region in tissue regeneration and cancer
Shared requirement for MYC upstream super-enhancer region in tissue regeneration and cancer Open
Cancer has been characterized as a wound that does not heal. Malignant cells are morphologically distinct from normal proliferating cells but have extensive similarities to tissues undergoing wound healing and/or regeneration. The mechanis…
View article: Multi-Omics Analysis Reveals the Attenuation of the Interferon Pathway as a Driver of Chemo-Refractory Ovarian Cancer
Multi-Omics Analysis Reveals the Attenuation of the Interferon Pathway as a Driver of Chemo-Refractory Ovarian Cancer Open
Ovarian high-grade serous carcinoma (HGSC) represents the deadliest gynecological malignancy, with 10-15% of patients exhibiting primary resistance to first-line chemotherapy. These primarily chemo-refractory patients have particularly poo…
View article: Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisation
Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisation Open
The tumour suppressor adenomatous polyposis coli (Apc) regulates diverse effector pathways essential for cellular homeostasis. Truncating mutations in Apc, leading to the loss of its Wnt pathway and microtubule regulatory domains, are onco…
View article: Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth
Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth Open
The gene desert upstream of the MYC oncogene on chromosome 8q24 contains susceptibility loci for several major forms of human cancer. The region shows high conservation between human and mouse and contains multiple MYC enhancers that are a…
View article: Author response: Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth
Author response: Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract The gene desert up…
View article: Mice deficient of<i>Myc</i>super-enhancer region reveal a differential control mechanism between normal and pathological growth
Mice deficient of<i>Myc</i>super-enhancer region reveal a differential control mechanism between normal and pathological growth Open
The gene desert upstream of the Myc oncogene on chromosome 8q24 contains susceptibility loci for several major forms of human cancer, including cancers of breast, prostate, and colon. The region shows high conservation between human and mo…