Indira Jayakumar
YOU?
Author Swipe
View article: Cellular therapies in post hematopoietic stem cell transplant and onco-critical care
Cellular therapies in post hematopoietic stem cell transplant and onco-critical care Open
Cellular therapies represent a major breakthrough in pediatric onco-critical care and transplantation, using living immune or stem cells to restore or enhance immune function, fight malignancy, and promote tissue repair. These therapies ha…
View article: Extracorporeal therapies in oncocritical care and transplant
Extracorporeal therapies in oncocritical care and transplant Open
Advances in pediatric hemato-oncology and transplantation have markedly improved outcomes for children with hematologic malignancies, immunodeficiencies, and organ failures. Nonetheless, complications such as graft-versus-host disease (GVH…
View article: Integrated Pediatric Intensive Care and Hematopoietic Stem Cell Transplantation Service Improves The Peri-Transplant Survival In Children
Integrated Pediatric Intensive Care and Hematopoietic Stem Cell Transplantation Service Improves The Peri-Transplant Survival In Children Open
Integrated care with the PICU team is the first step towards improving survival in these critically ill children. With timely intervention on the floors for CDEs and protocol-driven care in the PICU, we have demonstrated an increase in ove…
View article: Double-lumen endotracheal tube in pediatric intensive care unit: A lifesaver in a leukemic child with pulmonary hemorrhage: A case report
Double-lumen endotracheal tube in pediatric intensive care unit: A lifesaver in a leukemic child with pulmonary hemorrhage: A case report Open
We describe a case of life-threatening pulmonary hemorrhage in a boy with leukemia. He had episodes of massive hemoptysis for which he was intubated and resuscitated with multiple blood products, hemostatic measures (tranexamic acid and re…
View article: Therapeutic plasma exchange – To do or not to do?
Therapeutic plasma exchange – To do or not to do? Open
Plasmapheresis is an extracorporeal procedure that involves the separation of plasma from blood. When this plasma is replaced with a substitute fluid, the procedure is called therapeutic plasma exchange (TPE). This procedure is used to rem…
View article: Emerging spectrum of DOCK8 deficiency in children and challenges associated with providing treatment: experience from a tertiary referral centre in India
Emerging spectrum of DOCK8 deficiency in children and challenges associated with providing treatment: experience from a tertiary referral centre in India Open
The study describes the course of children with DOCK8 deficiency, their stormy clinical course, discrete infection pattern, and challenges during the treatment. The retrospective study included children up to 18 years of age diagnosed to h…
View article: Continuous renal replacement therapy during extracorporeal membrane oxygenation run: a questionary-based survey
Continuous renal replacement therapy during extracorporeal membrane oxygenation run: a questionary-based survey Open
Background: Extracorporeal membrane oxygenation is becoming a broadly available form of prolonged cardiopulmonary support. Given a higher risk of complications fluid overload and acute kidney injury with ECMO, its conjugation with renal re…
View article: Cytokine storm in HSCT for severe combined immunodeficiency infant with SARS-COV-2
Cytokine storm in HSCT for severe combined immunodeficiency infant with SARS-COV-2 Open
Hematopoietic stem cell transplant (HSCT) is the only potentially curative option for severe combined immunodeficiency (SCID) as they are extremely vulnerable to infections. Immunocompromised children are at a higher risk of SARS-CoV-2 inf…
View article: Successful matched unrelated donor hematopoietic stem cell transplantation for infantile Wolman disease
Successful matched unrelated donor hematopoietic stem cell transplantation for infantile Wolman disease Open
Introduction: Wolman disease is a rare genetic disorder with an autosomal recessive inheritance. A mutation in the LIPA gene causes lysosomal acid lipase (LAL) deficiency results in lipid storage and adrenal insufficiency. Death in early i…
View article: Chemotherapy for Childhood Acute Myeloid Leukemia and Associated Infections Over Two Decades in India: Timeline and Impact on Outcome
Chemotherapy for Childhood Acute Myeloid Leukemia and Associated Infections Over Two Decades in India: Timeline and Impact on Outcome Open
Background: Infection and relapse constitute the two main challenges in the management of acute myeloid leukemia (AML) in children. Real-world data in children treated in low-and-middle income countries are sparse as the cost of supportive…