Indu Arun
YOU?
Author Swipe
View article: Factors Associated with Nodal Recurrence in Patients with Differentiated Thyroid Cancer and Correlation with Microvessel and Microlymphatic Vessel Density
Factors Associated with Nodal Recurrence in Patients with Differentiated Thyroid Cancer and Correlation with Microvessel and Microlymphatic Vessel Density Open
Purpose: This study evaluates the patterns of failure in patients with differentiated thyroid cancer. It identifies clinicopathologic features and biomarkers, such as microvessel density (MVD) and microlymphatic vessel density (MVLD), asso…
View article: Outcomes of curative surgery and adjuvant radiation therapy in salivary duct carcinoma
Outcomes of curative surgery and adjuvant radiation therapy in salivary duct carcinoma Open
Introduction: Salivary duct carcinoma (SDC) forms an uncommon and aggressive subtype of salivary gland neoplasms with early recurrences and metastases. Their treatment includes surgery and adjuvant radiotherapy. They overexpress androgen r…
View article: Re-defining pT4b buccal mucosa squamous cell carcinoma: Looking beyond palliation in select patients
Re-defining pT4b buccal mucosa squamous cell carcinoma: Looking beyond palliation in select patients Open
Objectives: Reports in the last 2 decades suggest that selected patients with masticator space invasion can be treated surgically with reasonable survival. This study is an attempt to identify prognosticators for disease free (DFS) and ove…
View article: Uracil as a biomarker for spatial pyrimidine metabolism in the development of gingivobuccal oral squamous cell carcinoma
Uracil as a biomarker for spatial pyrimidine metabolism in the development of gingivobuccal oral squamous cell carcinoma Open
No biomarker has yet been identified that allows accurate diagnosis and prognosis of oral cancers. In this study, we investigated the presence of key metabolites in oral cancer using proton nuclear magnetic resonance (NMR) spectroscopy to …
View article: Overexpression of <scp><i>CD73</i></scp> is associated with recurrence and poor prognosis of gingivobuccal oral cancer as revealed by transcriptome and deep immune profiling of paired tumor and margin tissues
Overexpression of <span><i>CD73</i></span> is associated with recurrence and poor prognosis of gingivobuccal oral cancer as revealed by transcriptome and deep immune profiling of paired tumor and margin tissues Open
Background For various cancers, differences in response to treatment and subsequent survival period have been reported to be associated with variation in immune contextures. Aim We sought to identify whether such association exists in resp…
View article: Detection of Axillary Lymph Node Involvement in Early-Stage Breast Cancer: Comparison between Staging 18F-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography–Computed Tomography Scans, Mammography, and Sentinel Lymph Node Biopsy
Detection of Axillary Lymph Node Involvement in Early-Stage Breast Cancer: Comparison between Staging 18F-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography–Computed Tomography Scans, Mammography, and Sentinel Lymph Node Biopsy Open
Aims: The aim of this study was to evaluate the role of 18 F-2-fluoro-2-deoxy-D-glucose ( 18 F-FDG) positron emission tomography – computed tomography (PET-CT) scan in the detection of axillary lymph node (ALN) involvement and comparison w…
View article: Oncologic safety of breast conservation following NACT in women with locally advanced breast cancer
Oncologic safety of breast conservation following NACT in women with locally advanced breast cancer Open
BCS is technically feasible in LABC patients. LABC patients who respond well to NACT can be offered BCS without compromising survival outcomes.
View article: Impact of review of histopathology specimens at a tertiary oncology hospital in Eastern India – lessons learnt
Impact of review of histopathology specimens at a tertiary oncology hospital in Eastern India – lessons learnt Open
A central review of histopathology specimens at tertiary oncology hospitals is important for optimum patient care in the modern era of personalised medicine. The challenges of healthcare delivery and access to ancillary investigations face…
View article: Diagnostic performance and survival outcome following sentinel lymph node biopsy in breast cancer patients from a tertiary cancer centre in India
Diagnostic performance and survival outcome following sentinel lymph node biopsy in breast cancer patients from a tertiary cancer centre in India Open
SLNB should be offered as an axillary staging procedure to all eligible BC patients from developing countries to avoid the morbidity associated with ALND. Fluorescent dye can be used as an alternative for RI in a resource-constrained setup.
View article: Dedifferentiated chordoma, a case report
Dedifferentiated chordoma, a case report Open
Dedifferentiated chordoma is a rare variant of chordoma, exhibiting simultaneous presence of conventional chordoma and component of high grade sarcoma. It occurs either de novo or in the form of high grade transformation of a conventional …
View article: Relapsed Refractory Hodgkin Lymphoma and Brentuximab Vedotin-Bendamustine Combination Therapy as a Bridge to Transplantation: Real-World Evidence From a Middle-Income Setting and Literature Review
Relapsed Refractory Hodgkin Lymphoma and Brentuximab Vedotin-Bendamustine Combination Therapy as a Bridge to Transplantation: Real-World Evidence From a Middle-Income Setting and Literature Review Open
Introduction Despite high cure rates with standard treatment, 30% patients with Hodgkin lymphoma develop relapsed or refractory (R/R) disease. Salvage therapy followed by autologous hematopoietic cell transplantation (HCT) is considered st…
View article: Outcomes of diffuse large B-cell lymphoma in elderly patients – real-world experience from a middle-income country setting
Outcomes of diffuse large B-cell lymphoma in elderly patients – real-world experience from a middle-income country setting Open
DLBCL is a curable lymphoma in elderly patients with standard anthracycline and rituximab-based therapies. Improvement in outcomes largely depends on social and financial support to complete the scheduled treatments.
View article: Relapsed plasmablastic lymphoma in a HIV‐negative patient: Pushing the envelope
Relapsed plasmablastic lymphoma in a HIV‐negative patient: Pushing the envelope Open
This case emphasizes that, with the availability of novel immunotherapy agents (Daratumumab), and repurposed use of bortezomib, a patient with HIV‐negative relapsed PBL can be treated successfully and consolidated with an allogeneic haploi…
View article: Relapsed Plasmablastic Lymphoma in a HIV negative patient: pushing the envelope
Relapsed Plasmablastic Lymphoma in a HIV negative patient: pushing the envelope Open
We report a case of Plasmablastic Lymphoma occurring in a 45-year-old HIV-negative woman involving extra nodal sites including ovary, breast and adrenal glands. Prognostic outcomes are generally dismal. On relapse, she received conventiona…
View article: Diagnostic Performance of Indocyanine Green Plus Methylene Blue Versus Radioisotope Plus Methylene Blue Dye Method for Sentinel Lymph Node Biopsy in Node-Negative Early Breast Cancer
Diagnostic Performance of Indocyanine Green Plus Methylene Blue Versus Radioisotope Plus Methylene Blue Dye Method for Sentinel Lymph Node Biopsy in Node-Negative Early Breast Cancer Open
PURPOSE Sentinel lymph node biopsy (SLNB) by dual-dye method (radioisotope plus blue) is the gold standard for axillary staging in patients with breast cancer, but in developing countries, logistic issues and financial constraint play a vi…
View article: Pancreatic Adenocarcinoma with Primary Tumor Calcification and Calcified Liver Metastasis: Report of a Rare Case and Review of Literature
Pancreatic Adenocarcinoma with Primary Tumor Calcification and Calcified Liver Metastasis: Report of a Rare Case and Review of Literature Open
Calcification is a feature of benign pancreatic diseases such as chronic calcific pancreatitis (CCP) or benign pancreatic tumors such as solid and papillary epithelial neoplasm of the pancreas and serous cystadenoma. The presence of calcif…
View article: Analytical validation of a standardised scoring protocol for Ki67 immunohistochemistry on breast cancer excision whole sections: an international multicentre collaboration
Analytical validation of a standardised scoring protocol for Ki67 immunohistochemistry on breast cancer excision whole sections: an international multicentre collaboration Open
Aims The nuclear proliferation marker Ki67 assayed by immunohistochemistry has multiple potential uses in breast cancer, but an unacceptable level of interlaboratory variability has hampered its clinical utility. The International Ki67 in …
View article: A subtype of cancer-associated fibroblasts with lower expression of alpha-smooth muscle actin suppresses stemness through BMP4 in oral carcinoma
A subtype of cancer-associated fibroblasts with lower expression of alpha-smooth muscle actin suppresses stemness through BMP4 in oral carcinoma Open
Cancer-associated fibroblasts (CAFs) demonstrate the characteristics of myofibroblast differentiation by often expressing the ultrastructure of alpha-smooth muscle actin (αSMA). However, heterogeneity among cancer-associated fibroblasts (C…
View article: Sentinel and Non-Sentinel Lymph Node Metastasis Prediction and Validation of the MSKCC Nomograms for Indian Breast Cancer Patients
Sentinel and Non-Sentinel Lymph Node Metastasis Prediction and Validation of the MSKCC Nomograms for Indian Breast Cancer Patients Open
Background: Sentinel lymph node (SLN) biopsy accurately stages the axilla, but is time consuming and resource intensive. Nomograms and scoring systems have been developed, based on clinical and pathologic data available before surgery, to …
View article: Glycated haemoglobin versus oral glucose tolerance test in screening for gestational diabetes mellitus
Glycated haemoglobin versus oral glucose tolerance test in screening for gestational diabetes mellitus Open
Background: Glycated haemoglobin (HbA1c) has been documented as an easier, useful tool in diagnosis of diabetes and can be considered as a screening tool in GDM as compared to oral glucose tolerance test (OGTT) which has practical constrai…