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View article: P031 ANS activitposy during habitual sleep is associated with impaired cognition.
P031 ANS activitposy during habitual sleep is associated with impaired cognition. Open
Introduction Rescue & Recovery Workers (RRWs) exhibit a high prevalence of obstructive sleep apnea (OSA), insomnia, post-traumatic stress disorder (PTSD) and are at elevated risk of cognitive impairment. Proxy measurement of autonomic-nerv…
View article: Enhancing sleep, wakefulness, and cognition with transcranial photobiomodulation: a systematic review
Enhancing sleep, wakefulness, and cognition with transcranial photobiomodulation: a systematic review Open
Disruptions in sleep are common across clinical populations, particularly those with neurological and psychiatric disorders, making restorative sleep and sustained wakefulness a public health priority. Sleep is essential for brain function…
View article: 1157 The Impact of Chronic Rhinosinusitis on Insomnia Symptoms and Sleep Duration in World Trade Center Rescue and Recovery Workers
1157 The Impact of Chronic Rhinosinusitis on Insomnia Symptoms and Sleep Duration in World Trade Center Rescue and Recovery Workers Open
Introduction Chronic rhinosinusitis (CRS) is highly prevalent in World Trade Center rescue and recovery workers (WTCRRW) and was found to be a significant risk factor for shorter subjective sleep duration, sleepiness, sleep quality, and in…
View article: 0713 Challenging the 90-Day CPAP Adherence Standard: Insights into Disparities and Healthcare Inequities
0713 Challenging the 90-Day CPAP Adherence Standard: Insights into Disparities and Healthcare Inequities Open
Introduction The continuous positive airway pressure (CPAP) policy of Centers for Medicare & Medicaid Services (CMS) requires adherence over 90-days for continued coverage. This may result in premature treatment discontinuation, potentiall…
View article: 0619 Shallower Sleep by Odds Ratio Product Is Associated with Low Arousal Threshold When Adjusted for Confounding Obstructive Sleep Apnea Severity
0619 Shallower Sleep by Odds Ratio Product Is Associated with Low Arousal Threshold When Adjusted for Confounding Obstructive Sleep Apnea Severity Open
Introduction Odds ratio product (ORP) is an electroencephalography-based method for capturing sleep depth. Higher ORP indicates greater probability of sleep interruption by wakefulness (“shallower sleep”). A potential source of sleep inter…
View article: 1127 Actigraphy-Based Sleep Irregularity Measures and Cardiometabolic Imaging Biomarkers Using PET/MRI: A Descriptive Analysis
1127 Actigraphy-Based Sleep Irregularity Measures and Cardiometabolic Imaging Biomarkers Using PET/MRI: A Descriptive Analysis Open
Introduction There is mounting evidence that irregular sleep patterns are associated with impaired cardiometabolic health. However, few studies have explored this link independent of obstructive sleep apnea (OSA), an important confounder i…
View article: 0606 Demographic Differences in the Physiological Burdens of Sleep Apnea
0606 Demographic Differences in the Physiological Burdens of Sleep Apnea Open
Introduction Diagnosis of obstructive sleep apnea (OSA) depends on the Apnea-Hypopnea Index (AHI), a metric with acknowledged limitations, but known variation across demographic groups. Novel methodologies may better quantify OSA pathophys…
View article: 0690 Examining the Diagnostic Validity of PAT Device Against Concurrent Nocturnal Polysomnography Recording in a Community Dwelling Cohort of Older Adults
0690 Examining the Diagnostic Validity of PAT Device Against Concurrent Nocturnal Polysomnography Recording in a Community Dwelling Cohort of Older Adults Open
Introduction In a cohort of community dwelling participants, we previously showed a modest correlation for Obstructive Sleep Apnea (OSA) severity between WatchPAT™(WP) and polysomnography (PSG) used on separate night recordings. Given the …
View article: 1271 Cognitive Impairment and Sleep Disturbances in World Trade Center (WTC) Rescue and Recovery Workers and Volunteers
1271 Cognitive Impairment and Sleep Disturbances in World Trade Center (WTC) Rescue and Recovery Workers and Volunteers Open
Introduction World Trade Center rescue and recovery workers and volunteers (WTCRRWV) have elevated levels of poor sleep quality, insomnia symptoms and Obstructive Sleep Apnea (OSA). Increasing evidence of early onset of cognitive deficits …
View article: 0112 Impact of REM OSA and Hypoxic Burden on Sleep-Dependent Spatial Navigational Memory and White Matter Integrity in Cognitively Normal Elderly with OSA
0112 Impact of REM OSA and Hypoxic Burden on Sleep-Dependent Spatial Navigational Memory and White Matter Integrity in Cognitively Normal Elderly with OSA Open
Introduction Overnight sleep enhances spatial navigational performance, but such benefits may be minimized by OSA. In this study, we aimed to explore whether REM-specific OSA (REM AHI4%) and Hypoxic Burden (HB) influence overnight task per…
View article: 0604 Arousal Threshold Estimated by Phenotyping Using Polysomnography Is Lower Using Automated Arousal Scoring Compared to Manual Arousal Scoring
0604 Arousal Threshold Estimated by Phenotyping Using Polysomnography Is Lower Using Automated Arousal Scoring Compared to Manual Arousal Scoring Open
Introduction Phenotyping using polysomnography (PUP) is a computer-based method for “endotyping” obstructive sleep apnea (OSA) using clinical sleep study data. PUP provides estimates of mechanisms causing upper airway collapse in sleep: ar…
View article: 0114 Role of Encoding Opportunity and Change in Slow Wave Activity Across K-complexes on Sleep-Dependent Spatial Navigational Memory in Older Adults
0114 Role of Encoding Opportunity and Change in Slow Wave Activity Across K-complexes on Sleep-Dependent Spatial Navigational Memory in Older Adults Open
Introduction While younger adults show significant overnight spatial navigational memory (SNM) performance gains, older adults exhibit attenuated improvements, possibly due to reduced slow wave activity (SWA) during non-REM sleep. Older ad…
View article: Sleep-wake variation in body temperature regulates tau secretion and correlates with CSF and plasma tau
Sleep-wake variation in body temperature regulates tau secretion and correlates with CSF and plasma tau Open
Sleep disturbance is bidirectionally associated with an increased risk of Alzheimer's disease and other tauopathies. While the sleep-wake cycle regulates interstitial and cerebrospinal fluid (CSF) tau levels, the underlying mechanisms rema…
View article: Physiology Guided Machine Learning Approach to Predict Short and Long Term Outcomes of Obstructive Sleep Apnea
Physiology Guided Machine Learning Approach to Predict Short and Long Term Outcomes of Obstructive Sleep Apnea Open
Obstructive Sleep Apnea(OSA) is a chronic condition that affects 1 billion people worldwide. Apnea Hypopnea Index(AHI) is the clinical gold standard to measure the severity of OSA. This study highlights limitations in the apnea-hypopnea in…
View article: Obstructive Sleep Apnea, Platelet Aggregation, and Cardiovascular Risk
Obstructive Sleep Apnea, Platelet Aggregation, and Cardiovascular Risk Open
Background Although related, the precise mechanisms linking obstructive sleep apnea (OSA) and cardiovascular disease (CVD) are unclear. Platelets are mediators of CVD risk and thrombosis and prior studies suggested associations of OSA and …
View article: <scp>OSA</scp> pathophysiology: a contemporary update
<span>OSA</span> pathophysiology: a contemporary update Open
Defined as an elevated frequency of obstructive respiratory events in sleep, obstructive sleep apnoea (OSA) is driven by a combination of four pathophysiologic mechanisms: elevated upper airway collapsibility, unstable ventilatory control,…
View article: Lack of association of impaired upper airway sensation with the presence or absence of obstructive sleep apnoea or chronic rhinosinusitis in World Trade Center responders
Lack of association of impaired upper airway sensation with the presence or absence of obstructive sleep apnoea or chronic rhinosinusitis in World Trade Center responders Open
Objective Examine sensory function of the upper airway in four groups of subjects recruited from the World Trade Centre General Responder Cohort (WTCGRC), with/without obstructive sleep apnoea (OSA), and with/without chronic rhinosinusitis…
View article: Sleep-wake body temperature regulates tau secretion in mice and correlates with CSF and plasma tau in humans
Sleep-wake body temperature regulates tau secretion in mice and correlates with CSF and plasma tau in humans Open
The sleep-wake cycle regulates interstitial fluid and cerebrospinal fluid (CSF) tau levels in both mouse and human by mechanisms that remain unestablished. Here, we reveal a novel pathway by which wakefulness increases extracellular tau le…
View article: 0485 Can Hypoxic Burden Predict Improvement in Sleepiness and Cognition in Response to CPAP Treatment in OSA Patients?
0485 Can Hypoxic Burden Predict Improvement in Sleepiness and Cognition in Response to CPAP Treatment in OSA Patients? Open
Introduction Obstructive sleep apnea (OSA) affects more than 10% of older Americans and is associated with future comorbid conditions. The current method for measuring OSA severity, the apnea-hypopnea index (AHI), is poorly correlated to s…
View article: Reply to Gan <i>et al.</i>: Ventilatory Burden in Obstructive Sleep Apnea: A Novel Indicator for Assessing Severity?
Reply to Gan <i>et al.</i>: Ventilatory Burden in Obstructive Sleep Apnea: A Novel Indicator for Assessing Severity? Open
"Reply to: Ventilatory Burden in Obstructive Sleep Apnea: A Novel Indicator for Assessing Severity?." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Associations of Alzheimer’s disease Plasma Biomarkers' and slow wave sleep within Black and White Cognitively Normal Older‐Adults
Associations of Alzheimer’s disease Plasma Biomarkers' and slow wave sleep within Black and White Cognitively Normal Older‐Adults Open
Background We studied whether plasma levels of Aβ40, Aβ42, Aβ42/Aβ40, Tau, tau/Aβ42 and NfL are associated with slow wave sleep, and if this association varied within non‐Hispanic Whites and Blacks/African‐Americans. Method This was a cros…
View article: Ventilatory Burden as a Measure of Obstructive Sleep Apnea Severity Is Predictive of Cardiovascular and All-Cause Mortality
Ventilatory Burden as a Measure of Obstructive Sleep Apnea Severity Is Predictive of Cardiovascular and All-Cause Mortality Open
Rationale: The apnea-hypopnea index (AHI), used for the diagnosis of obstructive sleep apnea, captures only the frequency of respiratory events and has demonstrable limitations. Objectives: We propose a novel automated measure, termed "ven…
View article: 0543 Obstructive Sleep Apnea, Platelet Aggregation and Cardiovascular Risk
0543 Obstructive Sleep Apnea, Platelet Aggregation and Cardiovascular Risk Open
Introduction Obstructive sleep apnea (OSA) affects pathways implicated in the pathophysiology of cardiovascular disease (CVD) by poorly understood mechanisms. Platelets are key mediators of CVD risk and thrombosis and prior studies have su…
View article: 0885 Alzheimer’s disease progression risk in Cognitive Normal Older Adults with Obstructive Sleep Apnea using NIA-AA Research Framework
0885 Alzheimer’s disease progression risk in Cognitive Normal Older Adults with Obstructive Sleep Apnea using NIA-AA Research Framework Open
Introduction We determined risk profiles of strata-specific cognitive-normal (NL) older-adults with obstructive sleep apnea (OSA) characterized by their Aβ, P-Tau & T-tau (ATN) burden, on prospective AD stage-transition Methods Longitudina…
View article: 0739 Effect of Obstructive Sleep Apnea and Insomnia on Cognitive Impairment in World Trade Center (WTC) Responders
0739 Effect of Obstructive Sleep Apnea and Insomnia on Cognitive Impairment in World Trade Center (WTC) Responders Open
Introduction Mild Cognitive Impairment (MCI) is defined as a noticeable decline in cognitive abilities that doesn't interfere with daily activities; MCI may be a precursor of Alzheimer’s disease and related dementia. Elevated risk of MCI h…
View article: 0435 Machine-learned combination of ventilatory, hypoxic, and arousal burdens classifies daytime sleepiness better than AHI
0435 Machine-learned combination of ventilatory, hypoxic, and arousal burdens classifies daytime sleepiness better than AHI Open
Introduction The apnea-hypopnea index (AHI), the current severity metric used clinically for diagnosing obstructive sleep apnea (OSA), does not correlate well to daytime sleepiness measured via the Epworth Sleepiness Scale (ESS). Here, we …
View article: 0055 Effect of acute sleep restriction on sleep physiology and emotional imagery memory in schizophrenia
0055 Effect of acute sleep restriction on sleep physiology and emotional imagery memory in schizophrenia Open
Introduction Cognitive dysfunction in individuals with schizophrenia (SZ) represents a major determinant of poor functioning and may arise in part due to deficits in sleep quality that have been reported in in this population. In the curre…
View article: 0468 Effects of apnea-induced SWS disruption with and without supplemental oxygen on overnight spatial memory in CPAP-treated OSA
0468 Effects of apnea-induced SWS disruption with and without supplemental oxygen on overnight spatial memory in CPAP-treated OSA Open
Introduction Sleep disturbance from obstructive sleep apnea (OSA) impairs overnight memory processing. This may be mediated by changes to slow wave sleep (SWS) as less slow wave activity (SWA) is associated with worse overnight spatial and…