Indu Dhar
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View article: Serum Vitamin A Is Associated with Variations in the Relationship between Plasma B6 Vitamers and Cardiovascular Disease Risk
Serum Vitamin A Is Associated with Variations in the Relationship between Plasma B6 Vitamers and Cardiovascular Disease Risk Open
The relationship between vitamin B6 indexes and AMI risk varied according to serum Vit-A concentrations. Additional research is needed to clarify the importance of Vit-A and B6 bioavailability in atherosclerotic CVD. This trial was registe…
View article: Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris
Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris Open
Elevated plasma concentrations of several one-carbon metabolites are associated with increased CVD risk. Both diet-induced regulation and dietary content of one-carbon metabolites can influence circulating concentrations of these markers. …
View article: Trimethyllysine, trimethylamine N-oxide, and long-term risk of stroke: the western norway coronary angiography cohort
Trimethyllysine, trimethylamine N-oxide, and long-term risk of stroke: the western norway coronary angiography cohort Open
Background Trimethyllysine (TML) is a precursor of the gut-microbiota derived metabolite trimethylamine N-oxide (TMAO), and both biomarkers are associated with adverse cardiovascular outcomes. Whether circulating levels of TML or TMAO pred…
View article: Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: A prospective 2‐cohort study
Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: A prospective 2‐cohort study Open
Background Elevated plasma methylmalonic acid (MMA) is reported in patients with established coronary heart disease (CHD) and is considered a marker of vitamin B12 deficiency. Moreover, MMA‐dependent reactions have been linked to alteratio…
View article: Long-term prognostic value of trimethylamine N-oxide in community-based adults and patients with coronary heart disease
Long-term prognostic value of trimethylamine N-oxide in community-based adults and patients with coronary heart disease Open
Background Trimethylamine N-oxide (TMAO) is an amine oxide generated by gut microbial metabolism. Emerging evidence suggests pro-atherosclerotic and pro-inflammatory properties of TMAO; however, the clinical utility of circulating TMAO in …
View article: Circulating trimethylamine <i>N</i>‐oxide levels do not predict 10‐year survival in patients with or without coronary heart disease
Circulating trimethylamine <i>N</i>‐oxide levels do not predict 10‐year survival in patients with or without coronary heart disease Open
Background Trimethylamine N ‐oxide (TMAO) is an amine oxide generated by gut microbial metabolism. TMAO may contribute to atherothrombosis and systemic inflammation. However, the prognostic value of circulating TMAO for risk stratification…
View article: Circulating trimethyllysine predicts total and cardiovascular mortality in patients with and without coronary heart disease
Circulating trimethyllysine predicts total and cardiovascular mortality in patients with and without coronary heart disease Open
Background The carnitine precursor trimethyllysine (TML) is associated with the microbiota-derived metabolite trimethylamine N-oxide (TMAO) and predicts future cardiovascular events in patients with established coronary heart disease (CHD)…
View article: Trimethyllysine predicts all-cause and cardiovascular mortality in community-dwelling adults and patients with coronary heart disease
Trimethyllysine predicts all-cause and cardiovascular mortality in community-dwelling adults and patients with coronary heart disease Open
Aims Trimethyllysine (TML) is involved in carnitine synthesis, serves as a precursor of trimethylamine N-oxide (TMAO) and is associated with cardiovascular events in patients with established coronary heart disease (CHD). We prospectively …
View article: Cord Blood Haematological Parameters Reference Range Difference in Urban and Rural Population of West Bengal as Compared to Global Scenario
Cord Blood Haematological Parameters Reference Range Difference in Urban and Rural Population of West Bengal as Compared to Global Scenario Open
Background: Human umbilical cord blood is often discarded as a biomedical waste. We aimed to standardise a local cord blood reference range for the West Bengal population. The cord blood haematological values differ depending on ethnic, re…
View article: β-blocker use and risk of all-cause mortality in patients with coronary heart disease: effect modification by serum vitamin A
β-blocker use and risk of all-cause mortality in patients with coronary heart disease: effect modification by serum vitamin A Open
Aims Blockade of β-adrenoceptors reduces sympathetic nervous system activity and improves survival in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, any improvement in longevity among patients…
View article: Lipid parameters and vitamin A modify cardiovascular risk prediction by plasma neopterin
Lipid parameters and vitamin A modify cardiovascular risk prediction by plasma neopterin Open
Objectives Oxidised cholesterol metabolites are linked to increased production of the active vitamin A (Vit-A) form and monocyte/macrophage activation, which may be reflected by neopterin, a marker of both interferon-γ–mediated immune acti…
View article: Development and validation of a ceramide- and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients
Development and validation of a ceramide- and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients Open
Aims Distinct ceramide lipids have been shown to predict the risk for cardiovascular disease (CVD) events, especially cardiovascular death. As phospholipids have also been linked with CVD risk, we investigated whether the combination of ce…
View article: Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the <scp>WENBIT</scp> trial
Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the <span>WENBIT</span> trial Open
Objectives No individual homocysteine (Hcy) metabolite has been studied as a risk marker for coronary artery disease ( CAD ). Our objective was to examine Hcy‐thiolactone, a chemically reactive metabolite generated by methionyl‐ tRNA synth…
View article: Plasma Cystathionine and Risk of Incident Stroke in Patients With Suspected Stable Angina Pectoris
Plasma Cystathionine and Risk of Incident Stroke in Patients With Suspected Stable Angina Pectoris Open
Background Cystathionine is an intermediate product in the transsulfuration pathway and formed during the B6‐dependent conversion of methionine to cysteine. Elevated plasma cystathionine has been related to atherosclerosis, which is a majo…
View article: The risk association of plasma total homocysteine with acute myocardial infarction is modified by serum vitamin A
The risk association of plasma total homocysteine with acute myocardial infarction is modified by serum vitamin A Open
Background Plasma total homocysteine (tHcy) has been implicated in the development of cardiovascular disease, but the mechanisms remain unclear. Vitamin A (Vit-A) is involved in homocysteine metabolism and we therefore explored the potenti…
View article: Double Stranded RNA Dependent Protein Kinase (PKR) and Type 2 Diabetes
Double Stranded RNA Dependent Protein Kinase (PKR) and Type 2 Diabetes Open
Type 2 diabetes greatly increases the risk for developing cardiovascular and metabolic disorders.Despite recent development in medical science, scientific understandings on the root mechanisms of type 2 diabetes are still not fully underst…