Ines Bruns
2018
Disruption of peroxisome proliferator–activated receptor γ coactivator (PGC)-1α reverts key features of the neoplastic phenotype of glioma cells
2018 • Ines Bruns, Benedikt Sauer, Michael C. Burger, Jule A. Eriksson, Ute Hofmann, Yannick Braun, Patrick N. Harter, Anna‐Luisa Luger, Michael Ronellenf...
2018
Gene Suppression of Transketolase-Like Protein 1 (TKTL1) Sensitizes Glioma Cells to Hypoxia and Ionizing Radiation
2018 • Sonja Heller, Gabriele D. Maurer, Christina Wanka, Ute Hofmann, Anna‐Luisa Luger, Ines Bruns, Jörg Steinbach, Johannes Rieger
2017
Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death
2017 • Anna‐Luisa Thiepold, Nadja I. Lorenz, Martha Foltyn, Anna L. Engel, Iris Divé, Hans Urban, Sonja Heller, Ines Bruns, Ute Hofmann, Stefan Dröse, Pat...
2020
AMPK activation protects astrocytes from hypoxia‑induced cell death
2020 • Leli Barialai, Maja Strecker, Anna‐Luisa Luger, Manuel J�ger, Ines Bruns, Alina C. M. Sittig, Iris Mildenberger, Sonja Heller, Alberto Delaidelli,...
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Exploring foci of
2020-03-05
AMPK activation protects astrocytes from hypoxia‑induced cell death
2020-03-05 • Leli Barialai, Maja Strecker, Anna‐Luisa Luger, Manuel J�ger, Ines Bruns, Alina C. M. Sittig, Iris Mildenberger, Sonja Heller, Alberto Delaidelli,...
Adenosine monophosphate (AMP)‑activated protein kinase (AMPK) is a major cellular energy sensor that is activated by an increase in the AMP/adenosine triphosphate (ATP) ratio. This causes the initiation of adaptive cellular programs, leading to the inhibition of anabolic pathways and increasing ATP synthesis. AMPK indirectly inhibits mammalian target of rapamycin (mTOR) complex 1 (mTORC1), a serine/threonine kinase and central regulator of cell growth and metabolism, which integrates various growth inhibitory sign…
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Activation Function
Trait Activation Theory
Tetracycline-Controlled Transcriptional Activation
Carbon–Hydrogen Bond Activation
Macrophage Activation Syndrome
Fibroblast Activation Protein, Alpha
Mast Cell Activation Syndrome
Activation Energy
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Exploring foci of
2018-12-21
Disruption of peroxisome proliferator–activated receptor γ coactivator (PGC)-1α reverts key features of the neoplastic phenotype of glioma cells
2018-12-21 • Ines Bruns, Benedikt Sauer, Michael C. Burger, Jule A. Eriksson, Ute Hofmann, Yannick Braun, Patrick N. Harter, Anna‐Luisa Luger, Michael Ronellenf...
The peroxisome proliferator-activated receptor γ coactivator (PGC)-1α is a master regulator of mitochondrial biogenesis and controls metabolism by coordinating transcriptional events. Here, we interrogated whether PGC-1α is involved in tumor growth and the metabolic flexibility of glioblastoma cells. PGC-1α was expressed in a subset of established glioma cell lines and primary glioblastoma cell cultures. Furthermore, a higher PGC-1α expression was associated with an adverse outcome in the TCGA glioblastoma dataset…
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Peroxisome Proliferator-Activated Receptor
Peroxisome
Peroxisome Proliferator-Activated Receptor Gamma
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Exploring foci of
2018-07-25
Gene Suppression of Transketolase-Like Protein 1 (TKTL1) Sensitizes Glioma Cells to Hypoxia and Ionizing Radiation
2018-07-25 • Sonja Heller, Gabriele D. Maurer, Christina Wanka, Ute Hofmann, Anna‐Luisa Luger, Ines Bruns, Jörg Steinbach, Johannes Rieger
In several tumor entities, transketolase-like protein 1 (TKTL1) has been suggested to promote the nonoxidative part of the pentose phosphate pathway (PPP) and thereby to contribute to a malignant phenotype. However, its role in glioma biology has only been sparsely documented. In the present in vitro study using LNT-229 glioma cells, we analyzed the impact of TKTL1 gene suppression on basic metabolic parameters and on survival following oxygen restriction and ionizing radiation. TKTL1 was induced by hypoxia and by…
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Gene Haas
Mcat (Gene)
Gene Saks
Gene Gotti
Gene Wolfe
Gene Polymorphism
Calcitonin Gene-Related Peptide
Gene–Environment Interaction
Braf (Gene)
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Exploring foci of
2017-07-14
Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death
2017-07-14 • Anna‐Luisa Thiepold, Nadja I. Lorenz, Martha Foltyn, Anna L. Engel, Iris Divé, Hans Urban, Sonja Heller, Ines Bruns, Ute Hofmann, Stefan Dröse, Pat...
Glioblastomas are characterized by fast uncontrolled growth leading to hypoxic areas and necrosis. Signalling from EGFR via mammalian target of rapamycin complex 1 (mTORC1) is a major driver of cell growth and proliferation and one of the most commonly altered signalling pathways in glioblastomas. Therefore, epidermal growth factor receptor and mTORC1 signalling are plausible therapeutic targets and clinical trials with inhibitors are in progress. However, we have previously shown that epidermal growth factor rece…
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Hard Target
Bullseye (Target)
Target Australia
Hard Target 2
Human Target (2010 Tv Series)
Rut (Mammalian Reproduction)
Target Archery
Target Field
Intelligence, Surveillance, Target Acquisition, And Reconnaissance
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