Inês C. B. Martins
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View article: Microbiological Quality and Stability of Pharmaceutical Products in Europe: Discrepancies, Regulatory Perspectives and Challenges
Microbiological Quality and Stability of Pharmaceutical Products in Europe: Discrepancies, Regulatory Perspectives and Challenges Open
Microbial contamination in pharmaceutical products poses a significant threat to patient safety and drug efficacy. Despite stringent regulatory frameworks, discrepancies between the European Pharmacopoeia (Ph. Eur.) and the United States P…
View article: Microbiological Quality and Stability of Pharmaceutical Products in Europe: Discrepancies, Regulatory Perspectives and Challenges
Microbiological Quality and Stability of Pharmaceutical Products in Europe: Discrepancies, Regulatory Perspectives and Challenges Open
Microbial contamination in pharmaceutical products poses a significant threat to patient safety and drug efficacy. Despite stringent regulatory frameworks, discrepancies between the European Pharmacopoeia (Ph. Eur.) and the United States P…
View article: Tuberculosis: Cliché or Outsider?
Tuberculosis: Cliché or Outsider? Open
Tuberculosis is an infectious disease with the potential for multisystemic dissemination, including the central nervous system (CNS). It is difficult to diagnose when the central nervous system is involved. Brain biopsy is the diagnostic m…
View article: Indomethacin-omeprazole as therapeutic hybrids? Salt and co-amorphous systems enhancing physicochemical and pharmacological properties
Indomethacin-omeprazole as therapeutic hybrids? Salt and co-amorphous systems enhancing physicochemical and pharmacological properties Open
Multidrug therapeutic hybrids constitute a promising proposal to overcome problems associated with traditional formulations containing physical mixtures of drugs, potentially improving pharmacological and pharmaceutical performance. Indome…
View article: Amorphization of different furosemide polymorphic forms during ball milling: Tracking solid-to-solid phase transformations
Amorphization of different furosemide polymorphic forms during ball milling: Tracking solid-to-solid phase transformations Open
Ball milling is used, not only to reduce the particle size of pharmaceutical powders, but also to induce changes in the physical properties of drugs. In this work we prepared three crystal forms of furosemide (forms Ⅰ, Ⅱ, and Ⅲ) and studie…
View article: Recent Advances in Co-Former Screening and Formation Prediction of Multicomponent Solid Forms of Low Molecular Weight Drugs
Recent Advances in Co-Former Screening and Formation Prediction of Multicomponent Solid Forms of Low Molecular Weight Drugs Open
Multicomponent solid forms of low molecular weight drugs, such as co-crystals, salts, and co-amorphous systems, are a result of the combination of an active pharmaceutical ingredient (API) with a pharmaceutically acceptable co-former. Thes…
View article: Amorphization of different furosemide polymorphic forms during ball milling: tracking solid-to-solid phase transformations
Amorphization of different furosemide polymorphic forms during ball milling: tracking solid-to-solid phase transformations Open
Ball milling is used, not only to reduce the particle size of pharmaceutical powders, but also to induce changes in the physical properties of drugs. In this work we prepared three crystal forms of furosemide (forms Ⅰ, Ⅱ, and Ⅲ) and studie…
View article: CCDC 1997414: Experimental Crystal Structure Determination
CCDC 1997414: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Exploring the Role of Solvent Polarity in Mechanochemical Knoevenagel Condensation: In-situ Tracking and Isolation of Reaction Intermediates
Exploring the Role of Solvent Polarity in Mechanochemical Knoevenagel Condensation: In-situ Tracking and Isolation of Reaction Intermediates Open
Mechanochemistry has proven to be a highly effective method for the synthesis of organic compounds. We studied the kinetics of the catalyst-free Knoevenagel reaction between 4-nitrobenzaldehyde and malononitrile, activated and driven by ba…
View article: Unveiling polyamorphism and polyamorphic interconversions in pharmaceuticals: the peculiar case of hydrochlorothiazide
Unveiling polyamorphism and polyamorphic interconversions in pharmaceuticals: the peculiar case of hydrochlorothiazide Open
Polyamorphism has been a controversial and highly debated solid-state phenomenon in both material and pharmaceutical communities. Although some evidence of this fascinating phenomenon has been reported for several inorganic systems, and mo…
View article: Exploring the role of solvent polarity in mechanochemical Knoevenagel condensation: <i>in situ</i> investigation and isolation of reaction intermediates
Exploring the role of solvent polarity in mechanochemical Knoevenagel condensation: <i>in situ</i> investigation and isolation of reaction intermediates Open
Mechanochemistry has proven to be a highly effective method for the synthesis of organic compounds.
View article: Unveiling polyamorphism and polyamorphic interconversions in pharmaceuticals: the peculiar case of hydrochlorothiazide
Unveiling polyamorphism and polyamorphic interconversions in pharmaceuticals: the peculiar case of hydrochlorothiazide Open
Three polyamorphs of hydrochlorothiazide with distinct physicochemical properties were discovered. MD simulations show different dihedral angle distributions in polyamorphs I and II. Polyamorphs I and III were converted into polyamorph II.
View article: CSD 2124803: Experimental Crystal Structure Determination
CSD 2124803: Experimental Crystal Structure Determination Open
An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely availabl…
View article: Formation Mechanism of a Nano‐Ring of Bismuth Cations and Mono‐Lacunary Keggin‐Type Phosphomolybdate
Formation Mechanism of a Nano‐Ring of Bismuth Cations and Mono‐Lacunary Keggin‐Type Phosphomolybdate Open
A new hetero‐bimetallic polyoxometalate (POM) nano‐ring was synthesized in a one‐pot procedure. The structure consists of tetrameric units containing four bismuth‐substituted monolacunary Keggin anions including distorted [BiO 8 ] cubes. T…
View article: A Solvent‐free Strategy to Prepare Amorphous Salts of Folic Acid with Enhanced Solubility and Cell Permeability
A Solvent‐free Strategy to Prepare Amorphous Salts of Folic Acid with Enhanced Solubility and Cell Permeability Open
Eight new amorphous organic salts of folic acid (FA) were prepared by mechanochemistry. FA can prevent cardiovascular and neurological diseases. Mechanochemistry overcomes serious FA solubility issues avoiding the use of toxic solvents. Du…
View article: CCDC 2064453: Experimental Crystal Structure Determination
CCDC 2064453: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2064454: Experimental Crystal Structure Determination
CCDC 2064454: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Addendum: da Silva, J.L.F.; et al. The Lisbon Supramolecular Green Story: Mechanochemistry towards New Forms of Pharmaceuticals. Molecules 2020, 25, 2705
Addendum: da Silva, J.L.F.; et al. The Lisbon Supramolecular Green Story: Mechanochemistry towards New Forms of Pharmaceuticals. Molecules 2020, 25, 2705 Open
The authors wish to add funding project UIDB/00100/2020 into the Funding section of this paper [...]
View article: The Lisbon Supramolecular Green Story: Mechanochemistry towards New Forms of Pharmaceuticals
The Lisbon Supramolecular Green Story: Mechanochemistry towards New Forms of Pharmaceuticals Open
This short review presents and highlights the work performed by the Lisbon Group on the mechanochemical synthesis of active pharmaceutical ingredients (APIs) multicomponent compounds. Here, we show some of our most relevant contributions o…
View article: CCDC 1958159: Experimental Crystal Structure Determination
CCDC 1958159: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1958160: Experimental Crystal Structure Determination
CCDC 1958160: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1958161: Experimental Crystal Structure Determination
CCDC 1958161: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Insight into the Structure and Properties of Novel Imidazole-Based Salts of Salicylic Acid
Insight into the Structure and Properties of Novel Imidazole-Based Salts of Salicylic Acid Open
The preparation of new active pharmaceutical ingredient (API) multicomponent crystal forms, especially co-crystals and salts, is being considered as a reliable strategy to improve API solubility and bioavailability. In this study, three no…