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View article: Trastuzumab Deruxtecan in Previously Treated HER2-Low Metastatic Breast Cancer: Real-World Multicentric Study in the Portuguese Population
Trastuzumab Deruxtecan in Previously Treated HER2-Low Metastatic Breast Cancer: Real-World Multicentric Study in the Portuguese Population Open
Background/Objectives: Breast cancer is the most common malignant neoplasm in women and the leading cause of cancer-related death. Approximately 50% of HER2-negative breast cancers exhibit low expression of this protein (HER2-low). Trastuz…
View article: Lung Adenocarcinoma and Peripheral Blood Eosinophilia
Lung Adenocarcinoma and Peripheral Blood Eosinophilia Open
There are many causes of peripheral blood eosinophilia (PBE), including allergic, infectious, rheumatic, and hematologic disorders. Solid tumor cancers, such as lung cancer, can also cause PBE, and although rare, being diagnosed with PBE i…
View article: 195P Real-life experience of trastuzumab deruxtecan (T-DXd) in patients with HER2-positive advanced breast cancer: A multicentric Portuguese study
195P Real-life experience of trastuzumab deruxtecan (T-DXd) in patients with HER2-positive advanced breast cancer: A multicentric Portuguese study Open
Substantial improvement in survival has been seen in HER2+ advanced breast cancer (ABC) over the past years with the introduction and widespread use of multiple novel agents. The DESTINY-Breast02 trial compared the efficacy and safety of T…
View article: 237P Real-world safety and efficacy of trastuzumab-deruxtecan (T-DXd) in HER2-positive advanced breast cancer (ABC) elderly patients (pts): The TREX-Old retrospective registry
237P Real-world safety and efficacy of trastuzumab-deruxtecan (T-DXd) in HER2-positive advanced breast cancer (ABC) elderly patients (pts): The TREX-Old retrospective registry Open
One third of ABC pts is currently represented by women aged over 70. However, this population remains under-represented in clinical trials. Recently, T-DXd revolutionized the treatment of HER2 positive ABC, demonstrating its efficacy in DE…
View article: Association of Tumor-Infiltrating Lymphocytes With Survival in Stages II and III Colorectal Cancer
Association of Tumor-Infiltrating Lymphocytes With Survival in Stages II and III Colorectal Cancer Open
The tumor microenvironment is crucial in tumourigenesis, response to therapy, and elimination of tumor cells. Tumor-infiltrating lymphocytes (TILs) promote the host immune response and are associated with a better prognosis in colorectal c…
View article: Neutrophile-to-lymphocyte, lymphocyte-to-monocyte, and platelet-to-lymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer
Neutrophile-to-lymphocyte, lymphocyte-to-monocyte, and platelet-to-lymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer Open
Higher NLR is correlated with longer survival time. High LMR patients have a higher risk of decreasing T stage, whereas high PLR patients have higher odds of progressing under FLOT and dying. Patients with TSR and a pathological response h…
View article: Non-endometrioid endometrial cancer: Analysis of different adjuvant treatment modalities
Non-endometrioid endometrial cancer: Analysis of different adjuvant treatment modalities Open
In NEEC patients, DFS and OS analysis showed better prognosis in combination of CT+RT. Patients that underwent only RT had better survival outcomes when compared to those treated with CT only.
View article: Refining Therapy in Patients with HER2-Positive Breast Cancer with Central Nervous System Metastasis
Refining Therapy in Patients with HER2-Positive Breast Cancer with Central Nervous System Metastasis Open
Background: Brain metastasis (BM) is a major clinical problem in metastatic breast cancer (MBC), occurring in 50% of patients with human epidermal growth factor receptor 2-positive (HER2+) breast cancer. Historically omitted from clinical …
View article: Uncommon presentation of leptomeningeal carcinomatosis from gastric cancer: a case report
Uncommon presentation of leptomeningeal carcinomatosis from gastric cancer: a case report Open
Leptomeningeal carcinomatosis in gastric adenocarcinoma is very rare (0.16–0.69%). Breast cancer, lung cancer, melanoma and hematologic malignancies are the most common causes of leptomeningeal carcinomatosis. The diagnosis is usually esta…
View article: The Reality of Critical Cancer Patients in a Polyvalent Intensive Care Unit
The Reality of Critical Cancer Patients in a Polyvalent Intensive Care Unit Open
Background and objective With the increasing incidence of cancer and the rise in the survival rates of cancer patients, more and more oncological candidates are being considered for admission to intensive care units (ICU). Several studies …