Ines Leonhardt
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View article: Ex Vivo Immune Profiling in Patient Blood Enables Quantification of Innate Immune Effector Functions
Ex Vivo Immune Profiling in Patient Blood Enables Quantification of Innate Immune Effector Functions Open
Assessment of a patient’s immune function is critical in many clinical situations. One prominent example is sepsis, which results from a loss of immune homeostasis due to microbial infection and is characterized by a plethora of pro- and a…
View article: <i>Ex vivo</i>Immune Profiling in Patient Blood enables Quantification of innate immune Effector Functions
<i>Ex vivo</i>Immune Profiling in Patient Blood enables Quantification of innate immune Effector Functions Open
The immune response towards infection is a dynamic system combating invading pathogens to maintain homeostasis and the integrity of the body. Unbalanced immune response profiles determine many clinical syndromes including sepsis and thus p…
View article: Quantitative Simulations Predict Treatment Strategies Against Fungal Infections in Virtual Neutropenic Patients
Quantitative Simulations Predict Treatment Strategies Against Fungal Infections in Virtual Neutropenic Patients Open
The condition of neutropenia, i.e., a reduced absolute neutrophil count in blood, constitutes a major risk factor for severe infections in the affected patients. Candida albicans and Candida glabrata are opportunistic pathogens and the mos…
View article: Predictive Virtual Infection Modeling of Fungal Immune Evasion in Human Whole Blood
Predictive Virtual Infection Modeling of Fungal Immune Evasion in Human Whole Blood Open
Bloodstream infections by the human-pathogenic fungi Candida albicans and Candida glabrata increasingly occur in hospitalized patients and are associated with high mortality rates. The early immune response against these fungi in human blo…
View article: Specific and Novel microRNAs Are Regulated as Response to Fungal Infection in Human Dendritic Cells
Specific and Novel microRNAs Are Regulated as Response to Fungal Infection in Human Dendritic Cells Open
Within the last two decades, the incidence of invasive fungal infections has been significantly increased. They are characterized by high mortality rates and are often caused by Candida albicans and Aspergillus fumigatus. The increasing nu…
View article: Impact of the fungal quorum sensing molecule farnesol on human innate immune cells
Impact of the fungal quorum sensing molecule farnesol on human innate immune cells Open
Quorum sensing (QS) is a cell density-dependent mechanism that affects microbial metabolism and gene expression. In fungi, the QS phenomenon has first been described for the opportunistic pathogen C. albicans, which produces farnesol as a …