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View article: Elimination of damaged mitochondria during UVB‐induced senescence is orchestrated by NIX‐dependent mitophagy
Elimination of damaged mitochondria during UVB‐induced senescence is orchestrated by NIX‐dependent mitophagy Open
Skin aging is the result of two types of aging, “intrinsic aging” an inevitable consequence of physiologic and genetically determined changes and “extrinsic aging,” which is dependent on external factors such as exposure to sunlight, smoki…
View article: CLCA2: A Potential Guardian against Premature Senescence and Skin Aging
CLCA2: A Potential Guardian against Premature Senescence and Skin Aging Open
Cellular senescence, a state of irreversible growth arrest, is implicated in various age-related pathologies, including skin aging. In this study, we investigated the role of CLCA2, a calcium-activated chloride channel accessory protein, i…
View article: Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging
Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging Open
Aging of human skin is a complex process leading to a decline in homeostasis and regenerative potential of this tissue. Mitochondria are important cell organelles that have a crucial role in several cellular mechanisms such as energy produ…
View article: Depletion of growth differentiation factor 15 (<scp>GDF15</scp>) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts
Depletion of growth differentiation factor 15 (<span>GDF15</span>) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts Open
Growth differentiation factor 15 (GDF15) is a stress‐responsive cytokine also known as a mitokine; however, its role in mitochondrial homeostasis and cellular senescence remained elusive. We show here that knocking down GDF15 expression in…
View article: Effects of Air Pollution on Cellular Senescence and Skin Aging
Effects of Air Pollution on Cellular Senescence and Skin Aging Open
The human skin is exposed daily to different environmental factors such as air pollutants and ultraviolet (UV) light. Air pollution is considered a harmful environmental risk to human skin and is known to promote aging and inflammation of …
View article: A new model to investigate UVB-induced cellular senescence and pigmentation in melanocytes
A new model to investigate UVB-induced cellular senescence and pigmentation in melanocytes Open
Ultraviolet (UV) light is known to potentially damage human skin and accelerate the skin aging process. Upon UVB exposure, melanocytes execute skin protection by increasing melanin production. Senescent cells, including senescent melanocyt…
View article: tBHP treatment as a model for cellular senescence and pollution-induced skin aging
tBHP treatment as a model for cellular senescence and pollution-induced skin aging Open