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View article: Potent antimicrobial and anti-biofilm effects of Uvaria chamae on Staphylococcus aureus strains via potential cell wall interference and lack of resistance induction
Potent antimicrobial and anti-biofilm effects of Uvaria chamae on Staphylococcus aureus strains via potential cell wall interference and lack of resistance induction Open
U. chamae root extract exhibits strong, selective antibacterial activity with low toxicity, no resistance induction, and in vivo efficacy. These findings support its potential as a locally relevant option to combat AMR in Africa.
View article: Chlamydia pneumoniae relies on host glutathione for its growth and induces integrated stress response-mediated changes in macrophage glutathione metabolism
Chlamydia pneumoniae relies on host glutathione for its growth and induces integrated stress response-mediated changes in macrophage glutathione metabolism Open
The obligate intracellular bacterium Chlamydia pneumoniae can enter into persistent phenotype, which is refractory to antibiotics and causes prolonged inflammatory state in the host. Molecular mechanisms enabling C. pneumoniae intracellula…
View article: Anesthetic-like effects of ketamine in C. elegans
Anesthetic-like effects of ketamine in C. elegans Open
Transparency of Caenorhabditis elegans enables microscopic in vivo imaging of cellular processes, but immobilization is required due to high locomotor activity. Here, anesthetic-like effects of dissociate anesthetic ketamine in adult C. el…
View article: Anesthetic-like effects of ketamine in<i>C. elegans</i>
Anesthetic-like effects of ketamine in<i>C. elegans</i> Open
Transparency of C. elegans enables microscopic in vivo imaging of cellular processes, but immobilization is required due to high locomotor activity. Preservative NaN 3 is commonly used for this, but is associated with oxidative stress and …
View article: Tracking Chlamydia – Host interactions and antichlamydial activity in Caenorhabditis elegans
Tracking Chlamydia – Host interactions and antichlamydial activity in Caenorhabditis elegans Open
The fading efficacy of antibiotics is a growing global health concern due to its life-threatening consequences and increased healthcare costs. Non-genetic mechanisms of antimicrobial resistance, such as those employed by Chlamydia pneumoni…
View article: Design and synthesis of etrasimod derivatives as potent antibacterial agents against Gram-positive bacteria
Design and synthesis of etrasimod derivatives as potent antibacterial agents against Gram-positive bacteria Open
The emergence of multidrug-resistant bacteria along with a declining pipeline of clinically useful antibiotics has led to the urgent need for the development of more effective antibacterial agents. Inspired by our recent report on the anti…
View article: Impact of azithromycin, doxycycline and redox-active small molecules on amoxicillin-induced Chlamydia pneumoniae persistence
Impact of azithromycin, doxycycline and redox-active small molecules on amoxicillin-induced Chlamydia pneumoniae persistence Open
Amoxicillin is recommended as primary treatment for community-acquired bacterial pneumonia (CABP). 5-10% of CABP cases are caused by Chlamydia pneumoniae, an obligate intracellular bacterium which responds to beta-lactam antibiotics by con…
View article: Drop on Demand Antimicrobial Printed Coatings Loaded with Dehydroabietic Acid Derivative to Prevent Orthopedic Implant Infections
Drop on Demand Antimicrobial Printed Coatings Loaded with Dehydroabietic Acid Derivative to Prevent Orthopedic Implant Infections Open
View article: Repurposing the Sphingosine-1-Phosphate Receptor Modulator Etrasimod as an Antibacterial Agent Against Gram-Positive Bacteria
Repurposing the Sphingosine-1-Phosphate Receptor Modulator Etrasimod as an Antibacterial Agent Against Gram-Positive Bacteria Open
New classes of antibiotics are urgently needed in the fight against multidrug-resistant bacteria. Drug repurposing has emerged as an alternative approach to accelerate antimicrobial research and development. In this study, we screened a li…
View article: Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans
Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans Open
Guarana (Paullinia cupana) is a widely consumed nutraceutical with various health benefits supported by scientific evidence. However, its indirect health impacts through the gut microbiota have not been studied. Caenorhabditis elegans is a…
View article: Chlamydia pneumoniae Interferes with Macrophage Differentiation and Cell Cycle Regulation to Promote Its Replication
Chlamydia pneumoniae Interferes with Macrophage Differentiation and Cell Cycle Regulation to Promote Its Replication Open
Chlamydia pneumoniae is a ubiquitous intracellular bacterium which infects humans via the respiratory route. The tendency of C. pneumoniae to persist in monocytes and macrophages is well known, but the underlying host-chlamydial interactio…
View article: Screening of natural compounds identifies ferutinin as an antibacterial and anti-biofilm compound
Screening of natural compounds identifies ferutinin as an antibacterial and anti-biofilm compound Open
Antibacterial screenings are most commonly targeted at planktonic bacteria but less effort is dedicated to the exploration of agents acting on biofilms. Here, a natural compounds library was screened against Staphylococcus aureus us…
View article: Synthesis and Biological Evaluation of Fingolimod Derivatives as Antibacterial Agents
Synthesis and Biological Evaluation of Fingolimod Derivatives as Antibacterial Agents Open
We recently identified fingolimod as a potent antibiofilm compound by screening FDA-approved drugs. To study if the antibacterial activity of fingolimod could be further improved and to explore in-depth structure-activity relationships, we…
View article: Interlaboratory study for the evaluation of three microtiter plate-based biofilm quantification methods
Interlaboratory study for the evaluation of three microtiter plate-based biofilm quantification methods Open
View article: Surfaceome and Exoproteome Dynamics in Dual-Species Pseudomonas aeruginosa and Staphylococcus aureus Biofilms
Surfaceome and Exoproteome Dynamics in Dual-Species Pseudomonas aeruginosa and Staphylococcus aureus Biofilms Open
Bacterial biofilms are an important underlying cause for chronic infections. By switching into the biofilm state, bacteria can evade host defenses and withstand antibiotic chemotherapy. Despite the fact that biofilms at clinical and enviro…
View article: Interlaboratory study for the evaluation of three microtiter plate-based biofilm quantification methods
Interlaboratory study for the evaluation of three microtiter plate-based biofilm quantification methods Open
Data collected in the Print-aid interlaboratory study (ring trial) to evaluate the repeatability and reproducibility of three microtiter plate based methods: crystal violet, resazurin and plate counts. The files contain all the raw data co…
View article: Interlaboratory study for the evaluation of three microtiter plate-based biofilm quantification methods
Interlaboratory study for the evaluation of three microtiter plate-based biofilm quantification methods Open
Data collected in the Print-aid interlaboratory study (ring trial) to evaluate the repeatability and reproducibility of three microtiter plate based methods: crystal violet, resazurin and plate counts. The files contain all the raw data co…
View article: Screening of natural compounds identifies ferutinin as an antibacterial and anti-biofilm compound
Screening of natural compounds identifies ferutinin as an antibacterial and anti-biofilm compound Open
Antibacterial screenings are most commonly targeted at planktonic bacteria but less effort is dedicated to the exploration of agents acting on biofilms. Here, a natural compounds library was screened against Staphylococcus aureus us…
View article: Combined Effect of Naturally-Derived Biofilm Inhibitors and Differentiated HL-60 Cells in the Prevention of Staphylococcus aureus Biofilm Formation
Combined Effect of Naturally-Derived Biofilm Inhibitors and Differentiated HL-60 Cells in the Prevention of Staphylococcus aureus Biofilm Formation Open
Nosocomial diseases represent a huge health and economic burden. A significant portion is associated with the use of medical devices, with 80% of these infections being caused by a bacterial biofilm. The insertion of a foreign material usu…
View article: 3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency
3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency Open
Additive manufacturing technologies have been widely used in the medical field. More specifically, fused filament fabrication (FFF) 3D-printing technology has been thoroughly investigated to produce drug delivery systems. Recently, few res…
View article: Supplementary online material for PhD thesis manuscript Proteomic approaches to the characterization of tolerance and virulence in bacterial biofilms
Supplementary online material for PhD thesis manuscript Proteomic approaches to the characterization of tolerance and virulence in bacterial biofilms Open
These data belong to a PhD thesis manuscript Proteomic approaches to the characterization of tolerance and virulence in bacterial biofilms. Supplementary online material 1 Theoretical proteome of Staphylococcus aureus …
View article: Supplementary online material for PhD thesis manuscript Proteomic approaches to the characterization of tolerance and virulence in bacterial biofilms
Supplementary online material for PhD thesis manuscript Proteomic approaches to the characterization of tolerance and virulence in bacterial biofilms Open
These data belong to a PhD thesis manuscript Proteomic approaches to the characterization of tolerance and virulence in bacterial biofilms. Supplementary online material 1 Theoretical proteome of Staphylococcus aureus …
View article: Strategies to Prevent Biofilm Infections on Biomaterials: Effect of Novel Naturally-Derived Biofilm Inhibitors on a Competitive Colonization Model of Titanium by Staphylococcus aureus and SaOS-2 Cells
Strategies to Prevent Biofilm Infections on Biomaterials: Effect of Novel Naturally-Derived Biofilm Inhibitors on a Competitive Colonization Model of Titanium by Staphylococcus aureus and SaOS-2 Cells Open
Biofilm-mediated infection is a major cause of bone prosthesis failure. The lack of molecules able to act in biofilms has driven research aimed at identifying new anti-biofilm agents via chemical screens. However, to be able to accommodate…
View article: Strategies to Prevent Biofilm Infections on Biomaterials: Effect of Novel Naturally-Derived Biofilm Inhibitors on a Competitive Colonization Model of Titanium by <em>Staphylococcus aureus </em>and Human Cells
Strategies to Prevent Biofilm Infections on Biomaterials: Effect of Novel Naturally-Derived Biofilm Inhibitors on a Competitive Colonization Model of Titanium by <em>Staphylococcus aureus </em>and Human Cells Open
Biofilm-mediated infection is a major cause of bone prosthesis failure. The lack of molecules able to act in biofilms has driven research aimed at identifying new anti-biofilm agents via chemical screens. However, to be able to accommodate…
View article: Viola cornuta and Viola x wittrockiana: Phenolic compounds, antioxidant and neuroprotective activities on Caenorhabditis elegans
Viola cornuta and Viola x wittrockiana: Phenolic compounds, antioxidant and neuroprotective activities on Caenorhabditis elegans Open
Different Viola species are known for their traditional use as analgesic, antitussive, febrifuge, hipnotic, analgesic and anti-inflammatory medicinal agents. Additionally, they are considered edible flowers in certain cultures. Thus, the a…