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View article: Case report: Using DNA short tandem repeats to confirm nongestational origin of pulmonary choriocarcinoma
Case report: Using DNA short tandem repeats to confirm nongestational origin of pulmonary choriocarcinoma Open
Gestational trophoblastic neoplasias (GTN) are malignant neoplasms that occur in pregnant or recently pregnant women. Choriocarcinoma (CCA) is a highly aggressive and rare GTN, and cases outside the female genital tract are commonly seen a…
View article: The Meaning of Lymphadenopathies During Adjuvant Durvalumab After Chemoradiotherapy for Lung Cancer: Thinking Beyond Disease Progression
The Meaning of Lymphadenopathies During Adjuvant Durvalumab After Chemoradiotherapy for Lung Cancer: Thinking Beyond Disease Progression Open
Immune-checkpoint inhibitors (ICIs) have become the mainstay of treatment for many malignancies. With this new strategy, relevant immune-related adverse events (irAEs) have been reported, some of which can be mistaken for disease progressi…
View article: Flower lose, a cell fitness marker, predicts COVID‐19 prognosis
Flower lose, a cell fitness marker, predicts COVID‐19 prognosis Open
Risk stratification of COVID-19 patients is essential for pandemic management. Changes in the cell fitness marker, hFwe-Lose, can precede the host immune response to infection, potentially making such a biomarker an earlier triage tool. He…
View article: Phenotype-Genotype Correlation in Colorectal Cancer: A Real-Life Study
Phenotype-Genotype Correlation in Colorectal Cancer: A Real-Life Study Open
Background and Aims: Colorectal cancer (CRC) is a heterogeneous disease with distinctive genetic pathways, such as chromosomal instability, microsatellite instability and methylator pathway. Our aim was to correlate clinical and genetic ch…
View article: Eruptive Junctional Nevi Appearing During Langerhans Cell Histiocytosis Treatment
Eruptive Junctional Nevi Appearing During Langerhans Cell Histiocytosis Treatment Open
Langerhans cell histiocytosis (LCH) is a clonal neoplastic proliferation of immature Langerhans cells, with the V600E mutation in the BRAF oncogene present in approximately 60% of cases.The V600E mutation in the BRAF oncogene is also docum…
View article: An Unusual Presentation of Metastatic Breast Carcinoma
An Unusual Presentation of Metastatic Breast Carcinoma Open
Cutaneous metastases occur in approximately 0.7-10% of patients with invasive carcinomas and, when present, usually indicate an unfavourable outcome.Clinically, cutaneous metastasis can pose a diagnostic challenge and a high index of suspi…
View article: Mature cystic teratoma with high proportion of solid thyroid tissue: a controversial case with unusual imaging findings
Mature cystic teratoma with high proportion of solid thyroid tissue: a controversial case with unusual imaging findings Open
We describe a case of a mature cystic teratoma of the ovary with high proportion of solid thyroid tissue (< 50% of the entire tumor) in a childbearing woman. The patient presented with non-specific abdominal bloating. Pelvic ultrasound and…
View article: Immunoglobulin M gene association with autoantibody reactivity and type 1 diabetes
Immunoglobulin M gene association with autoantibody reactivity and type 1 diabetes Open
Several lines of evidence show that autoimmune responses evolving in type 1 diabetes (T1D) patients include the generation of multi-reactive autoantibody (AutoAb) repertoires, but their role in T1D pathogenesis remains elusive. We tested t…
View article: Transperineal aggressive angiomyxoma
Transperineal aggressive angiomyxoma Open
A 45-year-old woman with a history of total hysterectomy with adnexal preservation for uterine leiomyomas presented to our hospital with a right gluteal palpable mass, which she first noticed 6 months before and had progressively enlarged …
View article: Mid-Esophagus Columnar Metaplasia: What Is the Biopathogenic Pathway?
Mid-Esophagus Columnar Metaplasia: What Is the Biopathogenic Pathway? Open
We report a case of metaplastic columnar epithelium in the mid-esophagus in a patient with history of caustic ingestion. A cardiac-type gastric phenotype, with early signs of intestinalization, was confirmed by immunohistochemistry studies…