Inga Bauer
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View article: SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects Open
View article: Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells
Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells Open
Acid ceramidase (AC) hydrolyzes ceramides, which are central lipid messengers for metabolism and signaling of sphingolipids. A growing body of evidence links deregulation of sphingolipids to several diseases, including cancer. Indeed, AC e…
View article: Spezifizierung der fertilen Phase der Frau durch Farnkrautbestimmung im Speichel
Spezifizierung der fertilen Phase der Frau durch Farnkrautbestimmung im Speichel Open
In dieser Studie wurde die Validität des Speicheltests Geratherm ovu control hinsichtlich der Bestimmung der fertilen Phase und Ovulation der Frau untersucht und dabei dem etablierten Urintest EXACTO gegenübergestellt. 74 Probandinnen im A…
View article: The GSK3β inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level
The GSK3β inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level Open
The Yes-associated protein, YAP, is a transcriptional co-activator, mediating the Epithelial to Mesenchymal Transition program in pancreatic ductal adenocarcinoma (PDAC). With the aim to identify compounds that can specifically modulate YA…
View article: Molecular Simulations Integrated with Experiments Unravel the Key Factors of Lipid Selection in Fatty Acid Amide Hydrolase and Suggest A General Mechanism of Lipid-Processing in the Parent Enzymes
Molecular Simulations Integrated with Experiments Unravel the Key Factors of Lipid Selection in Fatty Acid Amide Hydrolase and Suggest A General Mechanism of Lipid-Processing in the Parent Enzymes Open
View article: Sirt6 regulates dendritic cell differentiation, maturation, and function
Sirt6 regulates dendritic cell differentiation, maturation, and function Open
Dendritic cells (DCs) are antigen-presenting cells that critically influence decisions about immune activation or tolerance. Impaired DC function is at the core of common chronic disorders and contributes to reduce immunocompetence during …
View article: Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics Open
View article: Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets
Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets Open
The fatty acid amide hydrolase (FAAH) regulates the endocannabinoid system cleaving primarily the lipid messenger anandamide. FAAH has been well characterized over the years and, importantly, it represents a promising drug target to treat …
View article: Structure of Human N -Acylphosphatidylethanolamine-Hydrolyzing Phospholipase D: Regulation of Fatty Acid Ethanolamide Biosynthesis by Bile Acids
Structure of Human N -Acylphosphatidylethanolamine-Hydrolyzing Phospholipase D: Regulation of Fatty Acid Ethanolamide Biosynthesis by Bile Acids Open