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View article: Epigenetic silencing of serine protease HTRA1 drives polyploidy
Epigenetic silencing of serine protease HTRA1 drives polyploidy Open
Downregulation of HTRA1 causes a number of phenotypes that are hallmarks of cancer cells suggesting that the methylation state of the HtrA1 promoter may be used as a biomarker for tumour cells or cells at risk of transformation.
View article: Additional file 1: of Epigenetic silencing of serine protease HTRA1 drives polyploidy
Additional file 1: of Epigenetic silencing of serine protease HTRA1 drives polyploidy Open
contains Supplementary method (Chromatin immunoprecipitation) and Table S1 (oligonucleotides used). Additional figure shows colocalisation of HTRA1 and microtubules in SW480 cells. (ZIP 394 kb)