Inga D. Neumann
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View article: Stress‐induced hyperphagia? Characterising the activity of the ghrelin axis in male rats with high anxiety behaviour
Stress‐induced hyperphagia? Characterising the activity of the ghrelin axis in male rats with high anxiety behaviour Open
While evidence is emerging that the temporal pattern of feeding may influence anxiety, it is unclear to what extent anxiety may itself impact spontaneous feeding behaviour. To address this, we have quantified spontaneous feeding, ghrelin s…
View article: Impaired social fear extinction in chronically stressed mice: Impact on inflammatory brain markers and the contribution of oxytocin
Impaired social fear extinction in chronically stressed mice: Impact on inflammatory brain markers and the contribution of oxytocin Open
Chronic psychosocial stress is a frequent burden in modern societies and risk factor for numerous somatic and affective disorders, including social anxiety disorder (SAD). Traumatic experiences after prolonged periods of stress exposure of…
View article: Oxytocin and dopamine in psychostimulant-induced changes in social behaviour
Oxytocin and dopamine in psychostimulant-induced changes in social behaviour Open
Oxytocin (OXT) plays a significant role in regulating social behaviour across various species, making it a key focus in neuroscience. Recent research has expanded beyond the established prosocial effects of OXT to explore its complex inter…
View article: The translocator protein 18 kDa (TSPO) ligand etifoxine in an animal model of anxiety: Line- and sex-dependent effects on emotionality, stress reactivity, spine density, oxytocin receptors, steroids, and microbiome composition
The translocator protein 18 kDa (TSPO) ligand etifoxine in an animal model of anxiety: Line- and sex-dependent effects on emotionality, stress reactivity, spine density, oxytocin receptors, steroids, and microbiome composition Open
The treatment of stress-related disorders such as anxiety and depression is still challenging. One potential therapeutical option are neurosteroids. Their synthesis is promoted by ligands of the mitochondrial translocator protein 18 kDa (T…
View article: Inga D. Neumann: Molecular underpinnings of the brain oxytocin system and its involvement in socio-emotional behaviour: More than a love story
Inga D. Neumann: Molecular underpinnings of the brain oxytocin system and its involvement in socio-emotional behaviour: More than a love story Open
Professor Inga Neumann stands at the forefront of neuropeptide research, bringing over three decades of expertise to her role as Chair of the Department of Behavioural and Molecular Neurobiology at the University of Regensburg, Germany. He…
View article: OXTR-mediated signaling in astrocytes contributes to anxiolysis
OXTR-mediated signaling in astrocytes contributes to anxiolysis Open
Astrocytes are an indispensable part of signal processing within the mammalian brain. Thus, the mode of action of a neuropeptide such as oxytocin (OXT) can only be fully understood considering this integral part of the CNS. Here, we show t…
View article: Beyond fur color: differences in socio-emotional behavior and the oxytocin system between male BL6 and CD1 mice in adolescence and adulthood
Beyond fur color: differences in socio-emotional behavior and the oxytocin system between male BL6 and CD1 mice in adolescence and adulthood Open
Introduction The development of stress-related psychopathologies, often associated with socio-emotional dysfunctions, is crucially determined by genetic and environmental factors, which shape the individual vulnerability or resilience to s…
View article: Mating-induced release of oxytocin in the mouse lateral septum: Implications for social fear extinction
Mating-induced release of oxytocin in the mouse lateral septum: Implications for social fear extinction Open
In mammals, some physiological conditions are associated with the high brain oxytocin (OXT) system activity. These include lactation in females and mating in males and females, both of which have been linked to reduced stress responsivenes…
View article: Functional involvement of septal miR-132 in extinction and oxytocin-mediated reversal of social fear
Functional involvement of septal miR-132 in extinction and oxytocin-mediated reversal of social fear Open
Social interactions are critical for mammalian survival and evolution. Dysregulation of social behavior often leads to psychopathologies such as social anxiety disorder, denoted by intense fear and avoidance of social situations. Using the…
View article: Monitoring oxytocin signaling in the brain: More than a love story
Monitoring oxytocin signaling in the brain: More than a love story Open
More than any other neuropeptide, oxytocin (OXT) is attracting the attention of neurobiologists, psychologists, psychiatrists, evolutionary biologists and even economists. It is often called a "love hormone" due to its many prosocial funct…
View article: Advances in human oxytocin measurement: challenges and proposed solutions
Advances in human oxytocin measurement: challenges and proposed solutions Open
Oxytocin, a neuropeptide known for its role in reproduction and socioemotional processes, may hold promise as a therapeutic agent in treating social impairments in patient populations. However, research has yet to uncover precisely how to …
View article: Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis
Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis Open
The neurotrophin brain-derived neurotrophic factor (BDNF) stimulates adult neurogenesis, but also influences structural plasticity and function of serotonergic neurons. Both, BDNF/TrkB signaling and the serotonergic system modulate behavio…
View article: Correction: Modelling sexual violence in male rats: the sexual aggression test (SxAT)
Correction: Modelling sexual violence in male rats: the sexual aggression test (SxAT) Open
peer reviewed
View article: Synthetic Oxytocin and Vasopressin Act Within the Central Amygdala to Exacerbate Aggression in Female Wistar Rats
Synthetic Oxytocin and Vasopressin Act Within the Central Amygdala to Exacerbate Aggression in Female Wistar Rats Open
Exacerbated aggression is a high-impact, but poorly understood core symptom of several psychiatric disorders, which can also affect women. Animal models have successfully been employed to unravel the neurobiology of aggression. However, de…
View article: Modelling sexual violence in male rats: The sexual aggression test (SxAT)
Modelling sexual violence in male rats: The sexual aggression test (SxAT) Open
Sexual assault and rape are crimes that impact victims worldwide. Although the psychosocial and eco-evolutionary factors associated with this antisocial behavior have repeatedly been studied, the underlying neurobiological mechanisms are s…
View article: Co-Stimulation of Oxytocin and Arginine-Vasopressin Receptors Affect Hypothalamic Neurospheroid Size
Co-Stimulation of Oxytocin and Arginine-Vasopressin Receptors Affect Hypothalamic Neurospheroid Size Open
Oxytocin (OXT) is a neuropeptide involved in a plethora of behavioral and physiological processes. However, there is a prominent lack of 3D cell culture models that investigate the effects of OXT on a cellular/molecular level. In this stud…
View article: Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats
Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats Open
In contrast to male rats, aggression in virgin female rats has been rarely studied. Here, we established a rat model of enhanced aggression in females using a combination of social isolation and aggression-training to specifically investig…