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View article: Investigating a Telerehabilitation Platform Integrated With a Rehabilitation Robot Using Microsoft HoloLens 2 for Upper-Limb Therapy: Pilot Usability Study
Investigating a Telerehabilitation Platform Integrated With a Rehabilitation Robot Using Microsoft HoloLens 2 for Upper-Limb Therapy: Pilot Usability Study Open
Background Upper-limb impairments following conditions such as stroke and spinal cord injury contribute significantly to long-term disability. Many survivors of stroke face limited access to rehabilitation due to geographical, financial, o…
View article: Hesperidin and Hesperetin from Orange Peel Water Extract Protect against NaIO <sub>3</sub> -Induced Oxidative Damage in Retinal Pigment Epithelial Cells by Modulating PI3K/Akt/HIF-1α/BNIP3 Signaling
Hesperidin and Hesperetin from Orange Peel Water Extract Protect against NaIO <sub>3</sub> -Induced Oxidative Damage in Retinal Pigment Epithelial Cells by Modulating PI3K/Akt/HIF-1α/BNIP3 Signaling Open
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly, with oxidative stress a major causative factor. Orange peel, rich in polyphenols and flavonoids, possesses potent antioxidant and anti-inflammatory acti…
View article: Tetrahydrocurcumin Protects Microglial Cells Against <i>Pseudomonas aeruginosa</i> Lipopolysaccharide-Induced Reactive Oxygen Species Production and Cathepsin B to Activate NLRP3 Inflammasome-Mediated Pyroptosis Via the HO-1 and p38/JNK Pathway
Tetrahydrocurcumin Protects Microglial Cells Against <i>Pseudomonas aeruginosa</i> Lipopolysaccharide-Induced Reactive Oxygen Species Production and Cathepsin B to Activate NLRP3 Inflammasome-Mediated Pyroptosis Via the HO-1 and p38/JNK Pathway Open
Tetrahydrocurcumin (THC), a major curcuminoid metabolite known for its antioxidant and anti-inflammatory properties, has potential for reducing brain inflammation. This study investigated THC's anti-inflammatory responses and molecular mec…
View article: From Code to Care and Digital Detection of Frailty: A Scoping Review of electronic Frailty Index (eFI) Applications Using Electronic Health Records
From Code to Care and Digital Detection of Frailty: A Scoping Review of electronic Frailty Index (eFI) Applications Using Electronic Health Records Open
The electronic Frailty Index (eFI) is a cumulative deficit model that quantifies frailty by summing health-related deficits recorded in a patient’s electronic health record. This scoping review evaluated the emerging applications of eFI mo…
View article: From Tiny Hands to Steady Hands to Weary Hands: Age-Related Change Rates in Grip Strength Across the Lifespan
From Tiny Hands to Steady Hands to Weary Hands: Age-Related Change Rates in Grip Strength Across the Lifespan Open
This study aimed to quantify the rate of change (kg/year) and percentage change (%) in grip strength across the lifespan (ages 3-85), stratified by gender and hand dominance. This was a cross-sectional observational study. Data were obtain…
View article: Development of a Game-Based Robotic System to Enhance Home-Based Robot-Assisted Therapy
Development of a Game-Based Robotic System to Enhance Home-Based Robot-Assisted Therapy Open
Each year, around 15 million people globally, including 795,000 Americans, experience a stroke. Nearly half of stroke survivors face persistent upper limb motor impairments, limiting daily activities and quality of life. This underscores t…
View article: Evaluating Safety and Usability of Robot-Aided Telerehabilitation System for Upper-limb Therapy
Evaluating Safety and Usability of Robot-Aided Telerehabilitation System for Upper-limb Therapy Open
Background Robot-assisted telerehabilitation (RAT) is an emerging field that integrates digital health technologies with robotics to deliver remote therapy, offering significant potential to overcome geographical and accessibility barriers…
View article: DISCORD BETWEEN SELF-REPORT AND PERFORMANCE-BASED ADL MEASURES AMONG PREFRAIL OR FRAIL OLDER ADULTS
DISCORD BETWEEN SELF-REPORT AND PERFORMANCE-BASED ADL MEASURES AMONG PREFRAIL OR FRAIL OLDER ADULTS Open
Prefrail and frail older adults face an increased risk of late-life disability. Detecting the decline in activities of daily living is essential to mitigate or reverse the progression of disability in this population. However, self-report …
View article: Examining the Psychometric Properties of the 10-Item Active Movement Scale (AMS) for Assessing Musculoskeletal Function in Adults
Examining the Psychometric Properties of the 10-Item Active Movement Scale (AMS) for Assessing Musculoskeletal Function in Adults Open
Objective: A movement screen is an efficient tool to evaluate movement patterns, detect potential dysfunctions and justify interventions aimed at improving musculoskeletal health. This study aimed to examine the reliability and validity of…
View article: Developing a tablet-based brain-computer interface and robotic prototype for upper limb rehabilitation
Developing a tablet-based brain-computer interface and robotic prototype for upper limb rehabilitation Open
Background The current study explores the integration of a motor imagery (MI)-based BCI system with robotic rehabilitation designed for upper limb function recovery in stroke patients. Methods We developed a tablet deployable BCI control o…
View article: Lemon Peel Water Extract: A Novel Material for Retinal Health, Protecting Retinal Pigment Epithelial Cells against Dynamin-Related Protein 1-Mediated Mitochondrial Fission by Blocking ROS-Stimulated Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway
Lemon Peel Water Extract: A Novel Material for Retinal Health, Protecting Retinal Pigment Epithelial Cells against Dynamin-Related Protein 1-Mediated Mitochondrial Fission by Blocking ROS-Stimulated Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway Open
Previous studies showed that NaIO3 can induce oxidative stress-mediated retinal pigment epithelium (RPE) damage to simulate age-related macular degeneration (AMD). Lemon peel is rich in antioxidants and components that can penetrate the bl…
View article: Developing an Accumulative Assessment System of Upper Extremity Motor Function in Patients With Stroke Using Deep Learning
Developing an Accumulative Assessment System of Upper Extremity Motor Function in Patients With Stroke Using Deep Learning Open
Objective The Fugl-Meyer assessment for upper extremity (FMA-UE) is a measure for assessing upper extremity motor function in patients with stroke. However, the considerable administration time of the assessment decreases its feasibility. …
View article: Assessing the Practical Differences in LDL-C Estimates Calculated by Friedewald, Martin/Hopkins, or NIH Equation 2: An Observation Cross-Sectional Study
Assessing the Practical Differences in LDL-C Estimates Calculated by Friedewald, Martin/Hopkins, or NIH Equation 2: An Observation Cross-Sectional Study Open
Understanding the practical differences in LDL-C calculations can be helpful in facilitating decision-making during a paradigm shift.
View article: More Problems, More Pain: The Role of Chronic Life Stressors and Racial/Ethnic Identity on Chronic Pain Among Middle-Aged and Older Adults in the United States
More Problems, More Pain: The Role of Chronic Life Stressors and Racial/Ethnic Identity on Chronic Pain Among Middle-Aged and Older Adults in the United States Open
There is a high prevalence of chronic pain among middle-aged and older adults in the United States. Chronic life stressors have been shown to have detrimental consequences for myriad health conditions, including chronic pain. However, ther…
View article: Evaluation of Objective Functions for the Optimal Design of an Assistive Robot
Evaluation of Objective Functions for the Optimal Design of an Assistive Robot Open
The number of individuals with upper or lower extremities dysfunction (ULED) has considerably increased in the past few decades, resulting in a high economic burden for their families and society. Individuals with ULEDs require assistive r…
View article: Trends in Low-Density Lipoproteins Cholesterol (LDL-C) in US Aged 12 to 80 Years: Data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES)
Trends in Low-Density Lipoproteins Cholesterol (LDL-C) in US Aged 12 to 80 Years: Data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES) Open
Background: Elevated levels of low-density lipoprotein cholesterol (LDL-C) are associated with an increased risk of coronary heart disease.
Objectives: We described LDL-C distributions across the age span and compared the trends in three …
View article: Control of a Wheelchair-Mounted 6DOF Assistive Robot With Chin and Finger Joysticks
Control of a Wheelchair-Mounted 6DOF Assistive Robot With Chin and Finger Joysticks Open
Throughout the last decade, many assistive robots for people with disabilities have been developed; however, researchers have not fully utilized these robotic technologies to entirely create independent living conditions for people with di…
View article: Optimal Design of a Cable-driven Wrist Prosthetic Device
Optimal Design of a Cable-driven Wrist Prosthetic Device Open
The amputation of a limb is a disabling condition that affects millions of people worldwide.This situation bolsters the necessity of devices that help the integration of those individuals into society.However, the design of such mechanisms…
View article: Effects of the Link Lengths in the Design and Optimization of A 6 DOFAssistive Robot for Activities of Daily Living
Effects of the Link Lengths in the Design and Optimization of A 6 DOFAssistive Robot for Activities of Daily Living Open
Patients with upper and lower extremity dysfunction suffer from a non-independent life.They depend on other people to do their daily activities.Hence, the importance of assistive robots in their lives and the design challenges of these rob…
View article: Suppressive Effect of Tetrahydrocurcumin on <i>Pseudomonas aeruginosa</i> Lipopolysaccharide‐Induced Inflammation by Suppressing JAK/STAT and Nrf2/HO‐1 Pathways in Microglial Cells
Suppressive Effect of Tetrahydrocurcumin on <i>Pseudomonas aeruginosa</i> Lipopolysaccharide‐Induced Inflammation by Suppressing JAK/STAT and Nrf2/HO‐1 Pathways in Microglial Cells Open
Brain inflammation, a pathological feature of neurodegenerative disorders, exhibits elevated microglial activity and increased levels of inflammatory factors. The present study was aimed at assessing the anti‐inflammatory response of tetra…
View article: Association Rule Mining to Examine Predictors for the Outcome of Gait Rehabilitation Programs in Stroke Survivors
Association Rule Mining to Examine Predictors for the Outcome of Gait Rehabilitation Programs in Stroke Survivors Open
This study presents a novel application of association rule data mining to determine the predictors of the response to locomotor training and home exercise for improving gait after stroke. The study was a secondary data analysis on the Loc…
View article: Eye-Gaze Control of a Wheelchair Mounted 6DOF Assistive Robot for Activities of Daily Living
Eye-Gaze Control of a Wheelchair Mounted 6DOF Assistive Robot for Activities of Daily Living Open
Background: Building control architecture that balances the assistive manipulation systems with the benefits of direct human control is a crucial challenge of human-robot collaboration. It promises to help people with disabilities more eff…
View article: Design and Development of an Upper Limb Rehabilitative Robot with Dual Functionality
Design and Development of an Upper Limb Rehabilitative Robot with Dual Functionality Open
The design of an upper limb rehabilitation robot for post-stroke patients is considered a benchmark problem regarding improving functionality and ensuring better human–robot interaction (HRI). Existing upper limb robots perform either join…
View article: A Novel Modified Super-Twisting Control Augmented Feedback Linearization for Wearable Robotic Systems Using Time Delay Estimation
A Novel Modified Super-Twisting Control Augmented Feedback Linearization for Wearable Robotic Systems Using Time Delay Estimation Open
The research presents a novel controller designed for robotic systems subject to nonlinear uncertain dynamics and external disturbances. The control scheme is based on the modified super-twisting method, input/output feedback linearization…
View article: Trends in TC/HDL and LDL/HDL Ratios across the Age Span: Data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES)
Trends in TC/HDL and LDL/HDL Ratios across the Age Span: Data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES) Open
Background. Cholesterol levels in total cholesterol (TC), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), and triglyceride (TG) contribute to atherosclerosis and its clinical consequences. Objectives. This study aimed to…
View article: Measurement of finger tapping performance using a smartphone application: a pilot study
Measurement of finger tapping performance using a smartphone application: a pilot study Open
[Purpose] Describe the measurement, reliability and validity of finger tapping repetitions recorded using a commercially available smartphone application (app). [Participants and Methods] We tested a convenience sample of 12 young right-ha…