Ingar Olsen
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Comparative analysis of antibodies to four major periodontal bacteria in respiratory diseases: a cohort study Open
Objectives To make a descriptive comparison of antibodies to four major periodontal bacteria and their relation to the respiratory diseases asthma and bronchitis/emphysema, and to cancer incidence. Methods The serum of a random sample of m…
Low level of antibodies to the oral bacterium Tannerella forsythia predicts bladder cancers and Treponema denticola predicts colon and bladder cancers: A prospective cohort study Open
This study explores the risk for cancer by level of antibodies to the anaerobe oral bacteria of periodontitis Tannerella forsythia (TF), Porphyromonas gingivalis (PG), and Treponema denticola (TD) all three collectively termed the red comp…
Porphyromonas gingivalis-Induced Neuroinflammation in Alzheimer’s Disease Open
“Chronic” periodontitis and its keystone pathogen Porphyromonas gingivalis have repeatedly been associated with Alzheimer’s disease (AD). Pathological hallmarks in AD are brain accumulations of amyloid-beta and neurofibrillary tangles cons…
Possible effects of <i>Porphyromonas gingivalis</i> on the blood–brain barrier in Alzheimer’s disease Open
The blood–brain barrier (BBB) is formed by brain capillary endothelial cells covered by membranes (Figure 1). It is surrounded by pericytes and astrocyte end-feet in a neurovascular unit (NVU) (Fig...
Can <i>Porphyromonas gingivalis</i> Contribute to Alzheimer’s Disease Already at the Stage of Gingivitis? Open
Alzheimer’s disease (AD) has been associated with periodontitis, which starts as gingivitis. Similar to periodontitis, gingivitis bacteria, bacterial products, and inflammatory mediators can travel to the brain via the blood stream and pro…
<i>Porphyromonas Gingivalis</i> May Seek the Alzheimer’s Disease Brain to Acquire Iron from Its Surplus Open
Iron accumulates in the brain of subjects with Alzheimer’s disease (AD). Here it promotes the aggregation of amyloid-β plaques in which it is abundant. Iron induces amyloid-β neurotoxicity by damaging free radicals and causing oxidative st…
<i>Porphyromonas gingivalis</i> infection may contribute to systemic and intracerebral amyloid-beta: implications for Alzheimer’s disease onset Open
The microbiota of “chronic” periodontitis, particularly Porphyromonas gingivalis, have been implicated in Alzheimer’s disease (AD) because this bacterium has a range of enzymes (cathepsin B and gingipains) that are shown to interact with t…
Is Porphyromonas gingivalis involved in Parkinson’s disease? Open
Porphyromonas gingivalis , a major subgingival plaque bacterium in periodontitis, has recently attracted much attention as a possible microbial driver in Alzheimer’s disease. In the present paper, another common neuroinflammatory disease, …
Low levels of antibodies for the oral bacterium Tannerella forsythia predict cardiovascular disease mortality in men with myocardial infarction: A prospective cohort study Open
Antibody levels to periodontal pathogens in prediction of cardiovascular disease (CVD) mortality were explored using data from a health survey in Oslo in 2000 (Oslo II-study) with 12 1/2 years follow-up. IgG antibodies to four common perio…
Role of EphA2 in host defense against oro-pharyngeal candidiasis Open
Oral defense should be able to sense the burden of, and distinguish between fungal commensals and pathogens, so that an adequate inflammatory response can be set up. Recently, Ephrin type-A receptor 2 (EphA2) was identified on oral epithel…
Mucus is more than just a physical barrier for trapping oral microorganisms Open
Mucus is thought to serve as a protective coating on wet epithelial surfaces. Recent research has shown that glycans, which are branched sugar molecules found in mucin, a part of mucus, can prevent bacteria from communicating with each oth…
Interaction between genetic factors, <i>Porphyromonas gingivalis</i> and microglia to promote Alzheimer’s disease Open
In late-onset Alzheimer disease (AD) pathogenesis, genes, infections and immunity could be significant factors. We have reviewed if the keystone periodontal pathogen Porphyromonas gingivalis may affect genes and microglia (primary immune c…
Oral microbiota and autism spectrum disorder (ASD) Open
Autism spectrum disorder (ASD) is associated with several oropharyngeal abnormalities, including dysbiosis in the oral microbiota. Since the oral cavity is the start of the gastrointestinal tract, this strengthens and extends the notion of…
Oral health and cardiovascular disease risk factors and mortality of cerebral haemorrhage, cerebral infarction and unspecified stroke in elderly men: A prospective cohort study Open
Background: Stroke mortality comprises different specific diagnoses as cerebral infarction, different haemorrhagic conditions and unspecified stroke. This study seeks to explore the prediction of oral health indicators versus known cardiov…
Is there a link between genetic defects in the complement cascade and<i>Porphyromonas gingivalis</i>in Alzheimer’s disease? Open
Defects, as determined by Genome-Wide Association Studies (GWAS), in the complement cascade of innate immunity have been suggested to play a key role in Alzheimer's disease (AD). These defective genes encode sub-component 1s (C1s), complem…
High Throughput Sequencing Detect Gingivitis And Periodontal Oral Bacteria In Alzheimer’s Disease Autopsy Brains Open
The sporadic form of Alzheimer’s disease (AD) is the most common form of dementia characterized microscopically by the presence of amyloid-beta (A?) plaques and tau neurofibrillary tangles with the clinical presentation of cognitive defici…
High Throughput Sequencing Detects Gingivitis and Periodontal Oral Bacteria in Alzheimer's Disease Autopsy Brains Open
The sporadic form of Alzheimer’s disease (AD) is the most common form of dementia characterized microscopically by the presence of amyloid-beta (Aβ) plaques and tau neurofibrillary tangles with the clinical presentation of cognitive defici…
<i>Porphyromonas gingivalis</i> and its CRISPR-Cas system Open
The clustered regularly interspaced short palindromic repeats (CRISPRs) and their associated proteins (Cas) are immune systems in prokaryotes present in most Bacteria and Archaea. They provide adaptive immunity against foreign elements suc…
Can oral bacteria affect the microbiome of the gut? Open
Oral bacteria spreading through the body have been associated with a number of systemic diseases. The gut is no exception. Studies in animals and man have indicated that oral bacteria can translocate to the gut and change its microbiota an…
Possible role of <i>Porphyromonas gingivalis</i> in orodigestive cancers Open
There is increasing evidence for an association between periodontitis/tooth loss and oral, gastrointestinal, and pancreatic cancers. Periodontal disease, which is characterized by chronic inflammation and microbial dysbiosis, is a signific…
Assessing the role of<i>Porphyromonas gingivalis</i>in periodontitis to determine a causative relationship with Alzheimer’s disease Open
Chronic periodontitis of 10 years' duration is reported to become a twofold risk factor for the development of Alzheimer's disease (AD). Periodontitis is modifiable, and this fits with the current action plan for preventing AD. However, un…
Periodontal Pathogens and Associated Intrathecal Antibodies in Early Stages of Alzheimer’s Disease Open
Background: Recent studies suggest a link between periodontitis and Alzheimer’s disease (AD). Objective: Verification of the presence of periodontal pathogens and the intrathecal generation of pathogen-specific antibodies in 20 patients wi…
Are Sphingolipids and Serine Dipeptide Lipids Underestimated Virulence Factors of Porphyromonas gingivalis? Open
The keystone periodontal pathogen Porphyromonas gingivalis produces phosphorylated dihydroceramide lipids (sphingolipids) such as phosphoethanolamine dihydroceramide (PE DHC) and phosphoglycerol dihydroceramide (PG DHC) lipids. Phosphoryla…
Are <i>Porphyromonas gingivalis</i> Outer Membrane Vesicles Microbullets for Sporadic Alzheimer’s Disease Manifestation? Open
Our research into Alzheimer’s disease (AD) focuses on the oral cavity and the brain, from which key evaluations of prospective and retrospective population-based data have shown that chronic periodontal disease existing for ten-years or ov…
Relationship between serine dipeptide lipids of commensal Bacteroidetes and atherosclerosis Open
Genera such as Porphyromonas, Prevotella, Tannerella and Capnocytophaga dominate among Bacteroidetes in the mouth [1]. Microorganisms of the phylum Bacteroidetes are also prevalent in the human int...
Importance of heterogeneity in <i>Porhyromonas gingivalis</i> lipopolysaccharide lipid A in tissue specific inflammatory signalling Open
Lipopolysaccharide (LPS) of Porphyromonas gingivalis exists in at least two known forms, O-LPS and A-LPS. A-LPS shows heterogeneity in which two isoforms designated LPS1,435/1,449 and LPS1,690 appear responsible for tissue-specific immune …
Oral microbiota in autoimmune polyendocrine syndrome type 1 Open
Background: Autoimmune polyendocrine syndrome type-1 (APS-1) is a rare, childhood onset disease caused by mutations in the Autoimmune Regulator gene. The phenotypic expression is highly variable and includes disease manifestations in the o…
Genetic exchange and reassignment in <i>Porphyromonas gingivalis</i> Open
Porphyromonas gingivalis is considered a keystone pathogen in adult periodontitis but has also been associated with systemic diseases. It has a myriad of virulence factors that differ between strains. Genetic exchange and intracellular gen…
Citrullination as a plausible link to periodontitis, rheumatoid arthritis, atherosclerosis and Alzheimer’s disease Open
Periodontitis, rheumatoid arthritis (RA), atherosclerosis (AS), and Alzheimer's disease (AD) are examples of complex human diseases with chronic inflammatory components in their etiologies. The initial trigger of inflammation that progress…