Inge Grondman
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View article: Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination
Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination Open
Aging affects human immune system functionality, increasing susceptibility to immune-mediated diseases. While gene expression programs accurately reflect immune function, their relationship with biological immune aging and health status re…
View article: A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity
A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity Open
Bacillus Calmette-Guérin (BCG) vaccination is a prototype model for the study of trained immunity (TI) in humans, and results in a more effective response of innate immune cells upon stimulation with heterologous stimuli. Here, we investig…
View article: Single-cell transcriptomics identifies different immune signatures between macrophage activation-like syndrome and immune paralysis in sepsis
Single-cell transcriptomics identifies different immune signatures between macrophage activation-like syndrome and immune paralysis in sepsis Open
Different immune phenotypes characterize sepsis patients, including hyperinflammation and/or immunosuppression, but the biological mechanisms driving this heterogeneity remain largely unknown. We used single-cell RNA sequencing to profile …
View article: THE ROLE OF OBESITY AND PLASMA ADIPOCYTOKINES IN IMMUNE DYSREGULATION IN SEPSIS PATIENTS
THE ROLE OF OBESITY AND PLASMA ADIPOCYTOKINES IN IMMUNE DYSREGULATION IN SEPSIS PATIENTS Open
Introduction: The dysregulated immune response in sepsis is highly variable, ranging from hyperinflammation to immunoparalysis. Obesity is associated with the release of inflammatory mediators from adipose tissue, known as adipocytokines, …
View article: Adipocytokine plasma concentrations reflect influence of inflammation but not body mass index (<scp>BMI</scp>) on clinical outcomes of <scp>COVID</scp>‐19 patients: A prospective observational study from the Netherlands
Adipocytokine plasma concentrations reflect influence of inflammation but not body mass index (<span>BMI</span>) on clinical outcomes of <span>COVID</span>‐19 patients: A prospective observational study from the Netherlands Open
Summary Obesity is recognized as a risk factor for adverse outcome in COVID‐19, but the molecular mechanisms underlying this relationship remain unknown. Adipose tissue functions as an endocrine organ by secreting multiple pro‐inflammatory…
View article: Targeted proteomics identifies circulating biomarkers associated with active COVID-19 and post-COVID-19
Targeted proteomics identifies circulating biomarkers associated with active COVID-19 and post-COVID-19 Open
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic is caused by the highly infectious Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). There is an urgent need for biomarkers that will help in better stratification of pat…
View article: Characterization of sepsis inflammatory endotypes using circulatory proteins in patients with severe infection: a prospective cohort study
Characterization of sepsis inflammatory endotypes using circulatory proteins in patients with severe infection: a prospective cohort study Open
Background Sepsis is a heterogeneous syndrome due to a variable range of dysregulated processes in the host immune response. Efforts are made to stratify patients for personalized immune-based treatments and better prognostic prediction. U…
View article: Systemic inflammation impairs human myelopoiesis and interferon I responses
Systemic inflammation impairs human myelopoiesis and interferon I responses Open
Systemic inflammation (SI) plays a detrimental role in various conditions with high mortality rates 1–4 . SI manifests an acute hyperinflammation followed by long-lasting immunosuppression, increasing patients’ risks for secondary infectio…
View article: The Genetic Risk for COVID-19 Severity Is Associated With Defective Immune Responses
The Genetic Risk for COVID-19 Severity Is Associated With Defective Immune Responses Open
Recent genome-wide association studies (GWASs) of COVID-19 patients of European ancestry have identified genetic loci significantly associated with disease severity. Here, we employed the detailed clinical, immunological and multi-omics da…
View article: A prospective observational cohort study to identify inflammatory biomarkers for the diagnosis and prognosis of patients with sepsis
A prospective observational cohort study to identify inflammatory biomarkers for the diagnosis and prognosis of patients with sepsis Open
Background Sepsis is a life-threatening organ dysfunction. A fast diagnosis is crucial for patient management. Proteins that are synthesized during the inflammatory response can be used as biomarkers, helping in a rapid clinical assessment…
View article: Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19
Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19 Open
Patients with sepsis display increased concentrations of sTREM-1 (soluble Triggering Receptor Expressed on Myeloid cells 1), and a phase II clinical trial focusing on TREM-1 modulation is ongoing. We investigated whether sTREM-1 circulatin…
View article: A prospective observational cohort study to identify inflammatory biomarkers for the diagnosis and prognosis of patients with sepsis
A prospective observational cohort study to identify inflammatory biomarkers for the diagnosis and prognosis of patients with sepsis Open
Background Sepsis is a life-threatening organ dysfunction. A fast diagnosis is crucial for patient management. Proteins that are synthesized during the inflammatory response can be used as biomarkers, helping in a rapid clinical assessment…
View article: Abnormal Thyroid Function Is Associated With Lymphopenia in Bacterial Sepsis and COVID-19
Abnormal Thyroid Function Is Associated With Lymphopenia in Bacterial Sepsis and COVID-19 Open
Background: Lymphopenia is a key feature of immune dysfunction in bacterial sepsis and COVID-19 patients and is associated with poor clinical outcomes, but the cause is largely unknown. These severely ill patients may also present with thy…
View article: The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19
The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19 Open
Context Lymphopenia is a key feature of immune dysfunction in patients with bacterial sepsis and coronavirus disease 2019 (COVID-19) and is associated with poor clinical outcomes, but the cause is largely unknown. Severely ill patients may…
View article: In vitro induction of trained immunity in adherent human monocytes
In vitro induction of trained immunity in adherent human monocytes Open
A growing number of studies show that innate immune cells can undergo functional reprogramming, facilitating a faster and enhanced response to heterologous secondary stimuli. This concept has been termed "trained immunity." We outline here…
View article: Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19
Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19 Open
The clinical spectrum of COVID-19 varies and the differences in host response characterizing this variation have not been fully elucidated. COVID-19 disease severity correlates with an excessive proinflammatory immune response and profound…
View article: Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study
Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study Open
Background A subset of critically ill COVID-19 patients develop a hyperinflammatory state. Anakinra, a recombinant interleukin-1 receptor antagonist, is known to be effective in several hyperinflammatory diseases. We investigated the effec…
View article: The genetic risk for COVID-19 severity is associated with defective innate immune responses
The genetic risk for COVID-19 severity is associated with defective innate immune responses Open
Recent genome-wide association studies (GWASs) of COVID-19 patients of European ancestry have identified genetic loci significantly associated with disease severity ( 1 ). Here, we employed the detailed clinical, immunological and multi-om…
View article: Complement Activation in the Disease Course of Coronavirus Disease 2019 and Its Effects on Clinical Outcomes
Complement Activation in the Disease Course of Coronavirus Disease 2019 and Its Effects on Clinical Outcomes Open
Background Excessive activation of immune responses in coronavirus disease 2019 (COVID-19) is considered to be related to disease severity, complications, and mortality rate. The complement system is an important component of innate immuni…
View article: Increased Plasma Heparanase Activity in COVID-19 Patients
Increased Plasma Heparanase Activity in COVID-19 Patients Open
Reports suggest a role of endothelial dysfunction and loss of endothelial barrier function in COVID-19. It is well established that the endothelial glycocalyx-degrading enzyme heparanase contributes to vascular leakage and inflammation. Lo…
View article: Increased plasma heparanase activity in COVID-19 patients
Increased plasma heparanase activity in COVID-19 patients Open
Reports suggest a role of endothelial dysfunction and loss of endothelial barrier function in COVID-19. It is well established that the endothelial glycocalyx-degrading enzyme heparanase contributes to vascular leakage and inflammation. Lo…
View article: A systems approach to inflammation identifies therapeutic targets in SARS-CoV-2 infection
A systems approach to inflammation identifies therapeutic targets in SARS-CoV-2 infection Open
Background Infection with SARS-CoV-2 manifests itself as a mild respiratory tract infection in the majority of individuals, which progresses to a severe pneumonia and acute respiratory distress syndrome (ARDS) in 10-15% of patients. Inflam…