Inge Timmers
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View article: Neural evidence for the effects of behavioral memory updating following fear conditioning
Neural evidence for the effects of behavioral memory updating following fear conditioning Open
View article: Oxytocin in Chronic Pain: From Analgesic to Biopsychosocial Adjuvant—An Opinion Paper
Oxytocin in Chronic Pain: From Analgesic to Biopsychosocial Adjuvant—An Opinion Paper Open
Chronic pain remains a major clinical challenge, with current treatments often providing insufficient relief. Oxytocin, classically recognized for its roles in reproduction and social bonding, has gained increasing attention for its potent…
View article: The Stress-Pain Connection in Chronic Primary Pain: A Systematic Review and Meta-Analysis of Physiological Stress Markers in Relation to Experimental Pain Responses
The Stress-Pain Connection in Chronic Primary Pain: A Systematic Review and Meta-Analysis of Physiological Stress Markers in Relation to Experimental Pain Responses Open
Dysfunctioning of stress systems, i.e., the autonomic nervous system (ANS) and hypothalamic-pituitary-adrenal (HPA) axis, has been implicated in chronic pain. However, the exact interplay between (re)activity and recovery of stress and pai…
View article: Correction: A comprehensive mapping of stress system interactions with pain and their contribution to chronification of musculoskeletal pain: Protocol of the STRAIN study
Correction: A comprehensive mapping of stress system interactions with pain and their contribution to chronification of musculoskeletal pain: Protocol of the STRAIN study Open
[This corrects the article DOI: 10.1371/journal.pone.0324089.].
View article: A comprehensive mapping of stress system interactions with pain and their contribution to chronification of musculoskeletal pain: Protocol of the STRAIN study
A comprehensive mapping of stress system interactions with pain and their contribution to chronification of musculoskeletal pain: Protocol of the STRAIN study Open
Background Stress is suggested to be an important factor contributing to the development and persistence of musculoskeletal pain. Although stress and pain interactions are well known, it remains largely unclear how (dys)function of the maj…
View article: Special Issue Registered Report: Intentional suppression as a method to boost fear extinction
Special Issue Registered Report: Intentional suppression as a method to boost fear extinction Open
View article: Seeing your child in pain: Parent empathy in the context of their child’s chronic pain
Seeing your child in pain: Parent empathy in the context of their child’s chronic pain Open
Observing your child in pain is inherently distressing. In the context of chronic pain, caregiver responses can powerfully impact child pain-related functioning. The Parent Empathy in the Context of Pain model postulates that parent empath…
View article: Tactile stimulation designs adapted to clinical settings result in reliable fMRI-based somatosensory digit maps
Tactile stimulation designs adapted to clinical settings result in reliable fMRI-based somatosensory digit maps Open
View article: Emotional memory bias in adolescents with chronic pain: examining the relationship with neural, stress, and psychological factors
Emotional memory bias in adolescents with chronic pain: examining the relationship with neural, stress, and psychological factors Open
Memory biases for pain-related information may contribute to the development and maintenance of chronic pain; however, evidence for when (and for whom) these biases occur is mixed. Therefore, we examined neural, stress, and psychological f…
View article: Probing white matter microstructure in youth with chronic pain and its relation to catastrophizing using neurite orientation dispersion and density imaging
Probing white matter microstructure in youth with chronic pain and its relation to catastrophizing using neurite orientation dispersion and density imaging Open
Chronic pain is common in young people and can have a major life impact. Despite the burden of chronic pain, mechanisms underlying chronic pain development and persistence are still poorly understood. Specifically, white matter (WM) connec…
View article: Altered neural oscillations in classical galactosaemia during sentence production
Altered neural oscillations in classical galactosaemia during sentence production Open
Classical galactosaemia (CG) is a hereditary disease in galactose metabolism that despite dietary treatment is characterized by a wide range of cognitive deficits, among which is language production. CG brain functioning has been studied w…
View article: Gray Matter Adaptations to Chronic Pain in People with Whiplash-Associated Disorders are Partially Reversed After Treatment: A Voxel-based Morphometry Study
Gray Matter Adaptations to Chronic Pain in People with Whiplash-Associated Disorders are Partially Reversed After Treatment: A Voxel-based Morphometry Study Open
View article: Use of Virtual Reality in Interdisciplinary Multimodal Pain Treatment With Insights From Health Care Professionals and Patients: Action Research Study
Use of Virtual Reality in Interdisciplinary Multimodal Pain Treatment With Insights From Health Care Professionals and Patients: Action Research Study Open
Background Chronic pain is a widespread global health problem. Interdisciplinary multimodal pain treatment (IMPT) is a treatment option for people with chronic pain. Virtual reality (VR) could be used to broaden IMPT programs. However, des…
View article: Neural processing of pain-related distress to neck-specific movements in people with chronic whiplash-associated disorders
Neural processing of pain-related distress to neck-specific movements in people with chronic whiplash-associated disorders Open
Pain-related distress contributes to long-term disability in chronic whiplash-associated disorders. Recently, neuroimaging studies have revealed altered neural responses to viewing pictures of movements associated with back pain in key reg…
View article: Tactile Stimulation Designs Adapted to Clinical Settings Result in Reliable fMRI-based Somatosensory Digit Maps
Tactile Stimulation Designs Adapted to Clinical Settings Result in Reliable fMRI-based Somatosensory Digit Maps Open
A wide range of neurological diseases with impaired motor functioning of the upper extremities are accompanied by impairments of somatosensory functioning, which are often undescribed but can provide crucial information for diagnostics, tr…
View article: Altered anterior insula functional connectivity in adolescent and young women with endometriosis-associated pain: Pilot resting-state fMRI study
Altered anterior insula functional connectivity in adolescent and young women with endometriosis-associated pain: Pilot resting-state fMRI study Open
View article: Paediatric chronic pain as a catalyst for toxic stress
Paediatric chronic pain as a catalyst for toxic stress Open
View article: Neural mechanisms underlying the conditioned pain modulation response: a narrative review of neuroimaging studies
Neural mechanisms underlying the conditioned pain modulation response: a narrative review of neuroimaging studies Open
Processing spatially distributed nociceptive information is critical for survival. The conditioned pain modulation (CPM) response has become a common psychophysical test to examine pain modulation capabilities related to spatial filtering …
View article: How do psychologically based interventions for chronic musculoskeletal pain work? A systematic review and meta-analysis of specific moderators and mediators of treatment
How do psychologically based interventions for chronic musculoskeletal pain work? A systematic review and meta-analysis of specific moderators and mediators of treatment Open
View article: Individual Patterns and Temporal Trajectories of Changes in Fear and Pain during Exposure In Vivo: A Multiple Single-Case Experimental Design in Patients with Chronic Pain
Individual Patterns and Temporal Trajectories of Changes in Fear and Pain during Exposure In Vivo: A Multiple Single-Case Experimental Design in Patients with Chronic Pain Open
Exposure in vivo (EXP) is an effective treatment to reduce pain-related fear and disability in chronic pain populations. Yet, it remains unclear how reductions in fear and pain relate to each other. This single-case experimental design stu…
View article: Exposure in Vivo as a Treatment Approach to Target Pain-Related Fear: Theory and New Insights From Research and Clinical Practice
Exposure in Vivo as a Treatment Approach to Target Pain-Related Fear: Theory and New Insights From Research and Clinical Practice Open
Pain-related fear (PRF) can be a significant factor contributing to the development and maintenance of pain-related disability in individuals with persistent pain. One treatment approach to target PRF and related avoidance behavior is expo…
View article: Temporal changes in pain processing after whiplash injury, based on Quantitative Sensory Testing: A systematic review
Temporal changes in pain processing after whiplash injury, based on Quantitative Sensory Testing: A systematic review Open
Background and Objective After whiplash injury, some patients develop chronic whiplash‐associated disorders. The exact pathophysiology of this chronification is still unclear and more knowledge is needed regarding the different post‐injury…
View article: Amygdala functional connectivity mediates the association between catastrophizing and threat-safety learning in youth with chronic pain
Amygdala functional connectivity mediates the association between catastrophizing and threat-safety learning in youth with chronic pain Open
There is a need to identify brain connectivity alterations predictive of transdiagnostic processes that may confer vulnerability for affective symptomology. Here, we tested whether amygdala resting-state functional connectivity (rsFC) medi…
View article: Corticolimbic Circuitry in Chronic Pain Tracks Pain Intensity Relief Following Exposure In Vivo
Corticolimbic Circuitry in Chronic Pain Tracks Pain Intensity Relief Following Exposure In Vivo Open
View article: Enhanced amygdala-frontal operculum functional connectivity during rest in women with chronic neck pain: Associations with impaired conditioned pain modulation
Enhanced amygdala-frontal operculum functional connectivity during rest in women with chronic neck pain: Associations with impaired conditioned pain modulation Open
View article: Subclinical post-traumatic stress symptomology and brain structure in youth with chronic headaches
Subclinical post-traumatic stress symptomology and brain structure in youth with chronic headaches Open
View article: The neural correlates of pain-related fear: A meta-analysis comparing fear conditioning studies using painful and non-painful stimuli
The neural correlates of pain-related fear: A meta-analysis comparing fear conditioning studies using painful and non-painful stimuli Open
Compared to the field of anxiety research, the use of fear conditioning paradigms for studying chronic pain is relatively novel. Developments in identifying the neural correlates of pain-related fear are important for understanding the mec…
View article: Clinicians´ initial experiences of transition to online interdisciplinary pain rehabilitation during the covid-19 pandemic
Clinicians´ initial experiences of transition to online interdisciplinary pain rehabilitation during the covid-19 pandemic Open
It is feasible to provide valid and satisfactory pain rehabilitation via videoconferencing. This study identified facilitators and barriers to the use of videoconferencing, and great potential for integrating aspects of telehealth into sta…
View article: Brain signatures of threat–safety discrimination in adolescent chronic pain
Brain signatures of threat–safety discrimination in adolescent chronic pain Open
Approximately 1.7 million youth suffer from debilitating chronic pain in the US alone, conferring risk of continued pain in adulthood. Aberrations in threat–safety (T–S) discrimination are proposed to contribute to pain chronicity in adult…
View article: The interaction between stress and chronic pain through the lens of threat learning
The interaction between stress and chronic pain through the lens of threat learning Open