Ingmar B. Schäfer
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View article: Antagonistic insulin mimetics lock the insulin receptor in an alternative apo-state
Antagonistic insulin mimetics lock the insulin receptor in an alternative apo-state Open
Despite significant advancements in high-resolution structural analysis of activated human insulin receptor (IR), the molecular mechanisms underlying its conformational plasticity that govern the transition from the apo state to the activa…
View article: Structural basis of mRNA decay by the human exosome–ribosome supercomplex
Structural basis of mRNA decay by the human exosome–ribosome supercomplex Open
The interplay between translation and mRNA decay is widespread in human cells 1–3 . In quality-control pathways, exonucleolytic degradation of mRNA associated with translating ribosomes is mediated largely by the cytoplasmic exosome 4–9 , …
View article: Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly
Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly Open
The Ski2-Ski3-Ski8 (Ski238) helicase complex directs cytoplasmic mRNAs toward the nucleolytic exosome complex for degradation. In yeast, the interaction between Ski238 and exosome requires the adaptor protein Ski7. We determined different …
View article: Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions
Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions Open
Messenger RNAs (mRNAs) are at the center of the central dogma of molecular biology. In eukaryotic cells, these long ribonucleic acid polymers do not exist as naked transcripts; rather, they associate with mRNA-binding proteins to form mess…
View article: The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions
The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions Open
View article: Symmetric and asymmetric receptor conformation continuum induced by a new insulin
Symmetric and asymmetric receptor conformation continuum induced by a new insulin Open
View article: The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism
The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism Open
View article: Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding
Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding Open
View article: Visualization of Insulin Receptor Activation by a Novel Insulin Analog with Elongated A Chain and Truncated B Chain
Visualization of Insulin Receptor Activation by a Novel Insulin Analog with Elongated A Chain and Truncated B Chain Open
Cone snail venoms contain a wide variety of bioactive peptides, including insulin-like molecules with distinct structural features, binding modes, and biochemical properties. Here, we report a fully active humanized cone snail venom insuli…
View article: Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3
Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3 Open
Repression of genes by Polycomb requires that PRC2 modifies their chromatin by trimethylating lysine 27 on histone H3 (H3K27me3). At transcriptionally active genes, di- and tri-methylated H3K36 inhibit PRC2. Here, the cryo-EM structure of …
View article: Author response: Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3
Author response: Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3 Open
View article: Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3
Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3 Open
Repression of genes by Polycomb requires that PRC2 modifies their chromatin by trimethylating lysine 27 on histone H3 (H3K27me3). At transcriptionally active genes, di- and trimethylated H3K36 inhibit PRC2. Here, the cryo-EM structure of P…
View article: Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain
Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain Open
Glucose homeostasis and growth essentially depend on the hormone insulin engaging its receptor. Despite biochemical and structural advances, a fundamental contradiction has persisted in the current understanding of insulin ligand–receptor …
View article: <scp>CENP</scp> ‐C unwraps the human <scp>CENP</scp> ‐A nucleosome through the H2A C‐terminal tail
<span>CENP</span> ‐C unwraps the human <span>CENP</span> ‐A nucleosome through the H2A C‐terminal tail Open
View article: CENP-C unwraps the CENP-A nucleosome through the H2A C-terminal tail
CENP-C unwraps the CENP-A nucleosome through the H2A C-terminal tail Open
Centromeres are defined epigenetically by nucleosomes containing the histone H3 variant CENP-A, upon which the constitutive centromere-associated network of proteins (CCAN) is built. CENP-C, is considered to be a central organizer of the C…
View article: Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain
Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain Open
Glucose homeostasis and growth essentially depend on the peptide hormone insulin engaging its receptor. Despite biochemical and structural advances, a fundamental contradiction has persisted in the current understanding of insulin ligand–r…
View article: Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase
Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase Open